CpG island demethylation and recruitment of SP1 to the promoter region regulates human thymic stromal lymphopoietin expression [0.03%]
5′-C-phosphate-G-3′岛去甲基化及SP1向启动子区募集调节人胸腺stromal淋巴细胞生成素表达
Krishna Priya Ganti,Milan Surjit
Krishna Priya Ganti
Thymic Stromal Lymphopoietin (TSLP), an immunomodulatory cytokine, plays a pivotal role in the development and progression of atopic and allergic diseases. Atopy follows familial inheritance, and genome-wide studies have shown association o...
Mapping DNA methylation to cardiac pathologies induced by beta-adrenergic stimulation in a large panel of mice [0.03%]
β肾上腺素刺激诱导的小鼠心肌病的DNA甲基化图谱分析
Caitlin Lahue,Eleanor Wong,Aryan Dalal et al.
Caitlin Lahue et al.
Heart failure (HF) is a major global health challenge, contributing to over 18 million deaths annually. While the roles of genetic and environmental factors are widely studied, the role of DNA methylation in HF pathogenesis is not fully und...
Mechanism of crosstalk between DNA methylation and histone acetylation and related advances in diagnosis and treatment of premature ovarian failure [0.03%]
DNA甲基化与组蛋白乙酰化的交叉谈及其在卵巢早衰诊断和治疗中的应用展望
Jing Li,Qianhui Liao,Yurou Guo et al.
Jing Li et al.
Premature ovarian failure (POF) affects 1-3.5% of women under 40 years of age, characterized by irreversible depletion of the follicular pool and decline in oocyte quality, with its pathogenesis remaining incompletely understood. Current ma...
Mendelian randomization analysis of CpG methylation and immune phenotypes in epithelial ovarian cancer outcomes [0.03%]
基底细胞卵巢癌结局中CpG甲基化和免疫表型的 Mendelian 随机化分析
Jiawei Li,Wanjun Luo,Daohong Nie et al.
Jiawei Li et al.
Epithelial ovarian cancer (EOC) is a heterogeneous malignancy with distinct histological subtypes, and DNA methylation has emerged as a promising biomarker for early detection. However, the role of methylation patterns in EOC heterogeneity ...
PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation [0.03%]
PIK3R1和G0S2与遗传的母系DNA甲基化相关的胎盘特异性印迹基因
Dagne Daskeviciute,Becky Sainty,Louise Chappell-Maor et al.
Dagne Daskeviciute et al.
Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methyla...
Fumonisin B1 induces global DNA hypermethylation in human glioblastoma U87MG cells [0.03%]
伏马毒素B1诱导人胶质母细胞瘤U87MG细胞的全基因组DNA高甲基化
Ashmika Foolchand,Terisha Ghazi,Anil A Chuturgoon
Ashmika Foolchand
Fumonisin B1 (FB1) is a common maize contaminant known to induce toxicity and carcinogenesis in humans and animals; however, its epigenetic mechanisms remain poorly understood. DNA methylation is an epigenetic modification that controls gen...
DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target [0.03%]
DNA甲基化与支气管扩张症：孟德尔随机化分析建立因果联系并探究治疗靶点
Jiangyue Qin,Bi Ran,Lian Liu et al.
Jiangyue Qin et al.
This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used...
The myoblast methylome: multiple types of associations with chromatin and transcription [0.03%]
肌管甲基化组：与染色质和转录的多种关联关系
Sagnik Sen,Michelle Lacey,Carl Baribault et al.
Sagnik Sen et al.
Epigenetic changes are implicated in development, repair, and physiology of postnatal skeletal muscle (SkM). We generated methylomes for human myoblasts (SkM progenitor cells) and determined myoblast differentially methylated regions (DMRs)...
Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis [0.03%]
基于表观基因转录组范围相关研究和区域分析的脐带血差别甲基化与胎儿时期接触周边犯罪行为的关系
Chantel L Martin,Jiawen Chen,Alena S D&#x;Alessio et al.
Chantel L Martin et al.
Exposure to prenatal social stressors during pregnancy is associated with adverse birth outcomes and has been linked to epigenetic changes in DNA methylation (DNAm); however, less understood is the effect of neighborhood-level stressors lik...
Long-lasting metabolic impairment in the failing heart: epigenetic memories at play [0.03%]
长期的心脏代谢障碍：表观遗传记忆的作用
Sarah Costantino,Francesco Paneni
Sarah Costantino
Understanding the factors involved in myocardial recovery after unloading is of utmost importance to unveil new therapies in patients with heart failure (HF). Lack of myocardial recovery might be explained by long-lasting molecular alterati...