PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein [0.03%]
PRMT1通过调节MYC蛋白精氨酸甲基化促进肝癌免疫逃逸
Han Zhou,Yang Wang,Dan Wang et al.
Han Zhou et al.
Arginine methyltransferase 1 (PRMT1) is widely recognized as an oncogene in various cancers. However, its specific role and underlying mechanisms in hepatocellular carcinoma (HCC) remain insufficiently understood. This study investigated th...
Dennis Khodasevich,Anne K Bozack,Saher Daredia et al.
Dennis Khodasevich et al.
Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed...
LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis [0.03%]
长链非编码RNA SCARNA8通过抑制巨噬细胞胞葬作用促进动脉粥样硬化斑块不稳定性
Xiaoliang Yin,Xiaodong Chen,Tao Wang et al.
Xiaoliang Yin et al.
In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of...
Leilei Wen,Xiaojing Zhang,Qiaoshan Yang et al.
Leilei Wen et al.
Acute urticaria can be a presenting symptom of anaphylaxis characterized by transient red swellings or fulminant wheals, often accompanied by severe pruritus. Numerous studies have substantiated the important involvement of regulatory T cel...
Higher sperm H3K4me3 levels are associated with idiopathic recurrent pregnancy loss [0.03%]
表观遗传学修饰H3K4me3水平增高与复发性流产相关
Delna Irani,Deepshikha Arya,Deepti Tandon et al.
Delna Irani et al.
During fertilization, spermatozoa contribute genetic and epigenetic factors such as chromatin packaged with protamines and histones; DNA methylome, non-coding RNAs, etc. Human sperm chromatin retains 5-15% nucleosomes which can play a key r...
Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes [0.03%]
乙醇代谢酶基因的甲基化和表达变化由醋酸醛驱动
Ji Sun Koo,Qiansheng Zhan,Huiping Zhang
Ji Sun Koo
This study examines how the alcohol metabolite acetaldehyde modulates mRNA methylation and expression of ethanol-metabolizing genes, uncovering its epigenetic role in ethanol metabolism. Using neuron-like (SH-SY5Y) and non-neuronal (SW620) ...
An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update [0.03%]
天然化合物调节结直肠癌表观遗传修饰的潜力概述：最新研究进展
Susmita Roy,Dikshita Deka,Suresh Babu Kondaveeti et al.
Susmita Roy et al.
Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes the critical role of epigenetic mechan...
A qualitative prognostic biomarker for melanoma based on the relative methylation orderings of CpG loci [0.03%]
基于CpG位点相对甲基化顺序的黑色素瘤定性预后生物标志物
Yue Huo,Yaru Gao,Jiayi Ruan et al.
Yue Huo et al.
Skin cutaneous melanoma (SKCM) is an aggressive tumor with a poor prognosis. We developed SKCM-P8, a novel qualitative prognostic biomarker based on the relative methylation orderings of eight pairs of loci. Analysis of a training cohort an...
CircMYH9 promotes the mRNA stability of SPAG6 by recruiting EIF4A3 to facilitate the progression of breast cancer [0.03%]
circMYH9通过招募EIF4A3来促进SPAG6的mRNA稳定性以促进乳腺癌进展
Shanji Fan,Ying Cui,Yingjie Liu et al.
Shanji Fan et al.
The incidence rate of breast cancer (BC) ranks first among female malignant tumors. Late-stage BC patients are at risk of death from distant metastasis. Circular RNAs (circRNAs) play an important function in cancer development. This study l...
Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations [0.03%]
与非洲巴西人群血压控制基因的差异甲基化有关的本质性高血压问题研究
Camila Cristina Avila Martins,Mariana Maschietto,Lilian Kimura et al.
Camila Cristina Avila Martins et al.
While genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability. This study focused on African...