ACMSD methylation in peripheral blood is associated with dynamic functional connectivity pattern in adolescent MDD patients [0.03%]
外周血ACMSD甲基化与青少年MDD患者功能连接动态模式有关
Maojia Ran,Meijiang Jin,Zhujun Wang et al.
Maojia Ran et al.
This study aimed to explore the association between ACMSD methylation level in peripheral blood and brain dynamic functional connectivity (dFC) patterns in adolescents with MDD. Sixty-seven drug-naive, first-episode adolescents with MDD (me...
Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm [0.03%]
三丁基锡氯化物改变雄性哺乳动物 ejaculation后精子的结构、基因组和表观遗传稳定性
Muhammad S Siddique,Santosh Anand,Marie-Pierre L Gauthier et al.
Muhammad S Siddique et al.
A global priority for ameliorating male factor infertility includes identification of environmental factors and mechanisms that impact sperm function. Detection of endocrine disrupting chemicals (EDC) in seminal plasma and within the female...
Correction [0.03%]
改正错误
Published Erratum
Epigenetics. 2025 Dec;20(1):2554384. DOI:10.1080/15592294.2025.2554384 2025
Adaptation and changing phenotypes through transgenerational epigenetics [0.03%]
跨世代表观遗传学与适应及性状变化的关系
Lon J Van Winkle,Rebecca J Ryznar,Philip M Iannaccone
Lon J Van Winkle
In this article collection, we describe how noncoding epigenetic changes in DNA are transmitted across multiple generations in eukaryotic organisms including plants and animals. And such environmentally induced biochemical alterations of DN...
Sex-stratified piRNA expression analysis reveals shared functional impacts of perinatal lead (Pb) exposure in murine hearts [0.03%]
性别分型的piRNA表达分析揭示了孕期铅(Pb)暴露对小鼠心脏功能影响的相似性
Kimberley E Sala-Hamrick,Kai Wang,Bambarendage P U Perera et al.
Kimberley E Sala-Hamrick et al.
The landscape of PIWI-interacting RNA (piRNA) expression in the heart is poorly understood, particularly regarding sex differences. Altered piRNA expression has been reported in cardiovascular disease (CVD), and although exposure to the met...
Ana Gabriela Vasconcelos,Mari Johnson,Yanwei Cai et al.
Ana Gabriela Vasconcelos et al.
Sickle cell trait (SCT) is due to heterozygosity for the β-globin sickle cell mutation. SCT recently has been associated with increased risk of various adverse health outcomes. DNA methylation (DNAm) is one potential mechanism by which SCT...
Meta-Analysis
Epigenetics. 2025 Dec;20(1):2539234. DOI:10.1080/15592294.2025.2539234 2025
Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES [0.03%]
系统免疫炎症指数（SII）与成人表观遗传学年龄加速的相关性：来自NHANES的见解
Rundong Liu,Mingjie Liu,Chendong Wang et al.
Rundong Liu et al.
The Systemic Immune-Inflammation Index (SII), a marker of systemic inflammation, has been linked to various age-related diseases, but its association with Epigenetic Age Acceleration (EAA) remains underexplored. This study aimed to investig...
Advancements in DNA methylation technologies and their application in cancer diagnosis [0.03%]
DNA甲基化技术的新进展及其在癌症诊断中的应用
Yang Yang,Xiaosha Wen,Li Wang
Yang Yang
DNA methylation is a common epigenetic modification that maintains the integrity of the DNA sequence while profoundly influencing gene expression and phenotypic variation. Aberrant DNA methylation has been associated with the onset and prog...
The role of histone methyltransferases in therapeutic resistance of NSCLC [0.03%]
组蛋白甲基转移酶在非小细胞肺癌获得性耐药中的作用研究
Fuze Zhu,Xudong Yang,Yanlong Yang et al.
Fuze Zhu et al.
Conventional treatments, including chemotherapy, immunotherapy, targeted therapy and radiotherapy, are effective clinical strategies for non-small cell lung cancer (NSCLC) patients, which can significantly improve life quality and prolong s...
GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study [0.03%]
基于回顾性队列研究的有效预测死亡风险的 GrimAge 和 GrimAge2 衰老加速表型
Tieshi Zhu,Yong He,Yixi Wang et al.
Tieshi Zhu et al.
Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality. However, the comparative predictive value of AAs derived from...