Mendelian randomization analysis of CpG methylation and immune phenotypes in epithelial ovarian cancer outcomes [0.03%]
基底细胞卵巢癌结局中CpG甲基化和免疫表型的 Mendelian 随机化分析
Jiawei Li,Wanjun Luo,Daohong Nie et al.
Jiawei Li et al.
Epithelial ovarian cancer (EOC) is a heterogeneous malignancy with distinct histological subtypes, and DNA methylation has emerged as a promising biomarker for early detection. However, the role of methylation patterns in EOC heterogeneity ...
PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation [0.03%]
PIK3R1和G0S2与遗传的母系DNA甲基化相关的胎盘特异性印迹基因
Dagne Daskeviciute,Becky Sainty,Louise Chappell-Maor et al.
Dagne Daskeviciute et al.
Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methyla...
Fumonisin B1 induces global DNA hypermethylation in human glioblastoma U87MG cells [0.03%]
伏马毒素B1诱导人胶质母细胞瘤U87MG细胞的全基因组DNA高甲基化
Ashmika Foolchand,Terisha Ghazi,Anil A Chuturgoon
Ashmika Foolchand
Fumonisin B1 (FB1) is a common maize contaminant known to induce toxicity and carcinogenesis in humans and animals; however, its epigenetic mechanisms remain poorly understood. DNA methylation is an epigenetic modification that controls gen...
DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target [0.03%]
DNA甲基化与支气管扩张症：孟德尔随机化分析建立因果联系并探究治疗靶点
Jiangyue Qin,Bi Ran,Lian Liu et al.
Jiangyue Qin et al.
This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used...
The myoblast methylome: multiple types of associations with chromatin and transcription [0.03%]
肌管甲基化组：与染色质和转录的多种关联关系
Sagnik Sen,Michelle Lacey,Carl Baribault et al.
Sagnik Sen et al.
Epigenetic changes are implicated in development, repair, and physiology of postnatal skeletal muscle (SkM). We generated methylomes for human myoblasts (SkM progenitor cells) and determined myoblast differentially methylated regions (DMRs)...
Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis [0.03%]
基于表观基因转录组范围相关研究和区域分析的脐带血差别甲基化与胎儿时期接触周边犯罪行为的关系
Chantel L Martin,Jiawen Chen,Alena S D&#x;Alessio et al.
Chantel L Martin et al.
Exposure to prenatal social stressors during pregnancy is associated with adverse birth outcomes and has been linked to epigenetic changes in DNA methylation (DNAm); however, less understood is the effect of neighborhood-level stressors lik...
Long-lasting metabolic impairment in the failing heart: epigenetic memories at play [0.03%]
长期的心脏代谢障碍：表观遗传记忆的作用
Sarah Costantino,Francesco Paneni
Sarah Costantino
Understanding the factors involved in myocardial recovery after unloading is of utmost importance to unveil new therapies in patients with heart failure (HF). Lack of myocardial recovery might be explained by long-lasting molecular alterati...
Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors [0.03%]
小鼠和人类心肌细胞复苏的转录特征显示表观遗传因素持续上调
Rebekka Roth,Margareta Häckh,Tilman Schnick et al.
Rebekka Roth et al.
Fibrosis, cardiac remodelling, and inflammation are hallmarks of heart failure. To date, there is no available pharmacological cure for heart failure, but mechanical unloading by implantation of a left ventricular assist device (LVAD) can l...
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway [0.03%]
新型长链非编码RNA(Lnc21q22.11)通过抑制MEK/ERK通路来抑制胃癌生长
Cheng Zhu,Meiying Zhang,Weili Yang et al.
Cheng Zhu et al.
Gastric cancer (GC) is one of the most common malignancies with limited treatment options and poor prognosis. Therefore, it is necessary to identify new markers for the development of novel therapeutic strategies. Long non-coding RNAs (lncR...
Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta [0.03%]
脐带血和胎盘的表观遗传特征：来自脐带血和胎盘的母体-胎儿健康的新见解
Jagadeesh Puvvula,Joseph M Braun,Emily A DeFranco et al.
Jagadeesh Puvvula et al.
The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment...