Adaptation and changing phenotypes through transgenerational epigenetics [0.03%]
跨世代表观遗传学与适应及性状变化的关系
Lon J Van Winkle,Rebecca J Ryznar,Philip M Iannaccone
Lon J Van Winkle
In this article collection, we describe how noncoding epigenetic changes in DNA are transmitted across multiple generations in eukaryotic organisms including plants and animals. And such environmentally induced biochemical alterations of DN...
Sex-stratified piRNA expression analysis reveals shared functional impacts of perinatal lead (Pb) exposure in murine hearts [0.03%]
性别分型的piRNA表达分析揭示了孕期铅(Pb)暴露对小鼠心脏功能影响的相似性
Kimberley E Sala-Hamrick,Kai Wang,Bambarendage P U Perera et al.
Kimberley E Sala-Hamrick et al.
The landscape of PIWI-interacting RNA (piRNA) expression in the heart is poorly understood, particularly regarding sex differences. Altered piRNA expression has been reported in cardiovascular disease (CVD), and although exposure to the met...
Ana Gabriela Vasconcelos,Mari Johnson,Yanwei Cai et al.
Ana Gabriela Vasconcelos et al.
Sickle cell trait (SCT) is due to heterozygosity for the β-globin sickle cell mutation. SCT recently has been associated with increased risk of various adverse health outcomes. DNA methylation (DNAm) is one potential mechanism by which SCT...
Meta-Analysis
Epigenetics. 2025 Dec;20(1):2539234. DOI:10.1080/15592294.2025.2539234 2025
Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES [0.03%]
系统免疫炎症指数（SII）与成人表观遗传学年龄加速的相关性：来自NHANES的见解
Rundong Liu,Mingjie Liu,Chendong Wang et al.
Rundong Liu et al.
The Systemic Immune-Inflammation Index (SII), a marker of systemic inflammation, has been linked to various age-related diseases, but its association with Epigenetic Age Acceleration (EAA) remains underexplored. This study aimed to investig...
Advancements in DNA methylation technologies and their application in cancer diagnosis [0.03%]
DNA甲基化技术的新进展及其在癌症诊断中的应用
Yang Yang,Xiaosha Wen,Li Wang
Yang Yang
DNA methylation is a common epigenetic modification that maintains the integrity of the DNA sequence while profoundly influencing gene expression and phenotypic variation. Aberrant DNA methylation has been associated with the onset and prog...
The role of histone methyltransferases in therapeutic resistance of NSCLC [0.03%]
组蛋白甲基转移酶在非小细胞肺癌获得性耐药中的作用研究
Fuze Zhu,Xudong Yang,Yanlong Yang et al.
Fuze Zhu et al.
Conventional treatments, including chemotherapy, immunotherapy, targeted therapy and radiotherapy, are effective clinical strategies for non-small cell lung cancer (NSCLC) patients, which can significantly improve life quality and prolong s...
GrimAge and GrimAge2 Age Acceleration effectively predict mortality risk: a retrospective cohort study [0.03%]
基于回顾性队列研究的有效预测死亡风险的 GrimAge 和 GrimAge2 衰老加速表型
Tieshi Zhu,Yong He,Yixi Wang et al.
Tieshi Zhu et al.
Epigenetic clocks have been widely applied to assess biological ageing, with Age Acceleration (AA) serving as a key metric linked to adverse health outcomes, including mortality. However, the comparative predictive value of AAs derived from...
CpG island demethylation and recruitment of SP1 to the promoter region regulates human thymic stromal lymphopoietin expression [0.03%]
5′-C-phosphate-G-3′岛去甲基化及SP1向启动子区募集调节人胸腺stromal淋巴细胞生成素表达
Krishna Priya Ganti,Milan Surjit
Krishna Priya Ganti
Thymic Stromal Lymphopoietin (TSLP), an immunomodulatory cytokine, plays a pivotal role in the development and progression of atopic and allergic diseases. Atopy follows familial inheritance, and genome-wide studies have shown association o...
Mapping DNA methylation to cardiac pathologies induced by beta-adrenergic stimulation in a large panel of mice [0.03%]
β肾上腺素刺激诱导的小鼠心肌病的DNA甲基化图谱分析
Caitlin Lahue,Eleanor Wong,Aryan Dalal et al.
Caitlin Lahue et al.
Heart failure (HF) is a major global health challenge, contributing to over 18 million deaths annually. While the roles of genetic and environmental factors are widely studied, the role of DNA methylation in HF pathogenesis is not fully und...
Mechanism of crosstalk between DNA methylation and histone acetylation and related advances in diagnosis and treatment of premature ovarian failure [0.03%]
DNA甲基化与组蛋白乙酰化的交叉谈及其在卵巢早衰诊断和治疗中的应用展望
Jing Li,Qianhui Liao,Yurou Guo et al.
Jing Li et al.
Premature ovarian failure (POF) affects 1-3.5% of women under 40 years of age, characterized by irreversible depletion of the follicular pool and decline in oocyte quality, with its pathogenesis remaining incompletely understood. Current ma...