The multifaceted role of lactate in cardiovascular health: from metabolism to signaling and epigenetics [0.03%]
乳酸在心血管健康中的多重作用：从代谢到信号传导和表观遗传学
J Konieczny,N Boardman,E Aasum et al.
J Konieczny et al.
Lactate, long regarded as a metabolic byproduct of anaerobic glycolysis, has emerged as a key regulator of cardiovascular health. Its roles extend beyond energy metabolism and include cell signaling through hydroxycarboxylic acid receptor 1...
Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load [0.03%]
整合DNA甲基化和转录组分析揭示了对升高的心理社会压力的细胞类型特异性反应模式
O Emery,C Carmeli,S Gonseth-Nusslé et al.
O Emery et al.
Allostatic load (AL) is a measure of the body's multi-systemic physiological dysregulation in response to chronic stress and life events. High AL has been associated with poor long-term health outcomes such as cardiovascular disease and mor...
Methylation differences between assisted reproductive technology-conceived and naturally conceived children near BRCA1 and NBR2 [0.03%]
辅助生殖技术受孕的儿童和自然受孕的儿童在BRCA1和NBR2附近的甲基化差异
Yunsung Lee,Håkon Kristian Gjessing,Christian Magnus Page et al.
Yunsung Lee et al.
Recent studies have shown that newborns conceived using assisted reproductive technology (ART) exhibited significantly different DNA methylation (DNAm) profiles at birth compared to those conceived naturally. Of note was the observation of ...
Chromatin structural gene expression stratifies cardiac cell populations in health and disease [0.03%]
染色质结构基因表达对健康和疾病中心脏细胞群进行分层
Xiaoxiao Geng,Rujula Pradeep,Riley Porter et al.
Xiaoxiao Geng et al.
Chromatin structure plays a central role in regulating gene expression and maintaining cellular identity, yet the structural factors driving these processes in cardiac disease remain poorly defined. To investigate whether these factors can ...
Insight into the mechanisms and dysregulation of KMT5C-H4K20me3 in cancer [0.03%]
揭秘组蛋白甲基转移酶KMT5C-H4K20me3在肿瘤中的工作机制及异常调控机制
Jihye Son,Andrea L Kasinski
Jihye Son
KMT5C-mediated histone H4 lysine 20 trimethylation (H4K20me3) has traditionally been linked to heterochromatin formation and maintenance, playing a crucial role in maintaining genome integrity. Emerging evidence, however, indicates that per...
Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging [0.03%]
基于欧洲血统的三项队列研究（包括加拿大的老年人纵向研究）鉴定出血源DNA甲基化水平与青光眼及眼压的关系
Xiaofan Jiang,Omar A Mahroo,Anthony P Khawaja et al.
Xiaofan Jiang et al.
Glaucoma is a major cause of blindness globally and its prevalence rises with age. This study explored systemic blood-derived DNA methylation epigenetic biomarkers for association with glaucoma and intraocular pressure (IOP). Blood-derived ...
Insights into WDR5: unveiling its functions, regulation, and impact on skeletal muscle [0.03%]
WDR5的研究进展：其功能、调控及其对骨骼肌的影响
Erick Bahena-Culhuac,Mauricio Hernández-Somilleda,José Manuel Hernández-Hernández
Erick Bahena-Culhuac
WD40-repeat-containing protein 5 (WDR5) is a highly conserved multifunctional scaffold protein with a toroidal structure, facilitating interactions with numerous partners through its WDR5-binding motif (WBM) and WDR5-interacting (WIN) sites...
Decitabine-induced DNA methylation remodeling reveals targetable biological processes in gilthead seabream pituitary and liver explants [0.03%]
脱氧胞苷诱导的DNA甲基化重塑揭示了金线鱼垂体和肝脏组织切片中可靶向的生物学过程
E Perera,C Navarro-Guillén,J Román-Padilla et al.
E Perera et al.
Epigenetic manipulations have the potential to improve traits in farmed fish. To explore this opportunity in the gilthead seabream (Sparus aurata), the catalytic domains of five DNA methyltransferases (DNMTs) were predicted by homology mode...
Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation [0.03%]
母体甲硫氨酸补充诱导绵羊卵母细胞和胚胎表观重编程
Jessica Townsend,Mehmet Kizilaslan,Zeynep Kizilaslan et al.
Jessica Townsend et al.
Environmental factors can influence gene expression and developmental outcomes through epigenetic modifications. Although maternal diet influences offspring DNA methylation and phenotypes, its effects on the oocyte and the resulting embryon...
Refeeding with different levels of dietary carbohydrate modulates epigenetic stability through global DNA (de)methylation and histone modifications in juvenile and adult Nile tilapia (Oreochromis niloticus) [0.03%]
不同碳水化合物水平的再喂养通过DNA（去）甲基化和组蛋白修饰调节尼罗罗非鱼幼鱼和成年鱼表观遗传稳定性
Sirijanya Thongchaitriwat,Suksan Kumkhong,Cécile Heraud et al.
Sirijanya Thongchaitriwat et al.
The Nile tilapia (Oreochromis niloticus) exhibits a strong metabolic response to dietary carbohydrates (CHO). Short-term refeeding after fasting with a high-carbohydrate (HC) diet has been shown to modulate CHO metabolism, but the role of e...