Chromatin structural gene expression stratifies cardiac cell populations in health and disease [0.03%]
染色质结构基因表达对健康和疾病中心脏细胞群进行分层
Xiaoxiao Geng,Rujula Pradeep,Riley Porter et al.
Xiaoxiao Geng et al.
Chromatin structure plays a central role in regulating gene expression and maintaining cellular identity, yet the structural factors driving these processes in cardiac disease remain poorly defined. To investigate whether these factors can ...
Insight into the mechanisms and dysregulation of KMT5C-H4K20me3 in cancer [0.03%]
揭秘组蛋白甲基转移酶KMT5C-H4K20me3在肿瘤中的工作机制及异常调控机制
Jihye Son,Andrea L Kasinski
Jihye Son
KMT5C-mediated histone H4 lysine 20 trimethylation (H4K20me3) has traditionally been linked to heterochromatin formation and maintenance, playing a crucial role in maintaining genome integrity. Emerging evidence, however, indicates that per...
Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging [0.03%]
基于欧洲血统的三项队列研究（包括加拿大的老年人纵向研究）鉴定出血源DNA甲基化水平与青光眼及眼压的关系
Xiaofan Jiang,Omar A Mahroo,Anthony P Khawaja et al.
Xiaofan Jiang et al.
Glaucoma is a major cause of blindness globally and its prevalence rises with age. This study explored systemic blood-derived DNA methylation epigenetic biomarkers for association with glaucoma and intraocular pressure (IOP). Blood-derived ...
Insights into WDR5: unveiling its functions, regulation, and impact on skeletal muscle [0.03%]
WDR5的研究进展：其功能、调控及其对骨骼肌的影响
Erick Bahena-Culhuac,Mauricio Hernández-Somilleda,José Manuel Hernández-Hernández
Erick Bahena-Culhuac
WD40-repeat-containing protein 5 (WDR5) is a highly conserved multifunctional scaffold protein with a toroidal structure, facilitating interactions with numerous partners through its WDR5-binding motif (WBM) and WDR5-interacting (WIN) sites...
Decitabine-induced DNA methylation remodeling reveals targetable biological processes in gilthead seabream pituitary and liver explants [0.03%]
脱氧胞苷诱导的DNA甲基化重塑揭示了金线鱼垂体和肝脏组织切片中可靶向的生物学过程
E Perera,C Navarro-Guillén,J Román-Padilla et al.
E Perera et al.
Epigenetic manipulations have the potential to improve traits in farmed fish. To explore this opportunity in the gilthead seabream (Sparus aurata), the catalytic domains of five DNA methyltransferases (DNMTs) were predicted by homology mode...
Epigenetic remodeling of sheep oocytes and embryos induced by maternal methionine supplementation [0.03%]
母体甲硫氨酸补充诱导绵羊卵母细胞和胚胎表观重编程
Jessica Townsend,Mehmet Kizilaslan,Zeynep Kizilaslan et al.
Jessica Townsend et al.
Environmental factors can influence gene expression and developmental outcomes through epigenetic modifications. Although maternal diet influences offspring DNA methylation and phenotypes, its effects on the oocyte and the resulting embryon...
Refeeding with different levels of dietary carbohydrate modulates epigenetic stability through global DNA (de)methylation and histone modifications in juvenile and adult Nile tilapia (Oreochromis niloticus) [0.03%]
不同碳水化合物水平的再喂养通过DNA（去）甲基化和组蛋白修饰调节尼罗罗非鱼幼鱼和成年鱼表观遗传稳定性
Sirijanya Thongchaitriwat,Suksan Kumkhong,Cécile Heraud et al.
Sirijanya Thongchaitriwat et al.
The Nile tilapia (Oreochromis niloticus) exhibits a strong metabolic response to dietary carbohydrates (CHO). Short-term refeeding after fasting with a high-carbohydrate (HC) diet has been shown to modulate CHO metabolism, but the role of e...
ACMSD methylation in peripheral blood is associated with dynamic functional connectivity pattern in adolescent MDD patients [0.03%]
外周血ACMSD甲基化与青少年MDD患者功能连接动态模式有关
Maojia Ran,Meijiang Jin,Zhujun Wang et al.
Maojia Ran et al.
This study aimed to explore the association between ACMSD methylation level in peripheral blood and brain dynamic functional connectivity (dFC) patterns in adolescents with MDD. Sixty-seven drug-naive, first-episode adolescents with MDD (me...
Tributyltin chloride alters the structural, genomic, and epigenomic integrity of postejaculatory mammalian sperm [0.03%]
三丁基锡氯化物改变雄性哺乳动物 ejaculation后精子的结构、基因组和表观遗传稳定性
Muhammad S Siddique,Santosh Anand,Marie-Pierre L Gauthier et al.
Muhammad S Siddique et al.
A global priority for ameliorating male factor infertility includes identification of environmental factors and mechanisms that impact sperm function. Detection of endocrine disrupting chemicals (EDC) in seminal plasma and within the female...
Correction [0.03%]
改正错误
Published Erratum
Epigenetics. 2025 Dec;20(1):2554384. DOI:10.1080/15592294.2025.2554384 2025