LncRNA Dlx4os drives malignant transformation and phenotype switching in melanoma [0.03%]
长链非编码RNA Dlx4os在黑色素瘤恶性转化及表型转变中的驱动作用
Ana Luisa Pedroso Ayub,Beatriz Cristina Biz Tonin,Hátylas Azevedo et al.
Ana Luisa Pedroso Ayub et al.
Cutaneous melanoma, a highly aggressive and therapy-resistant skin cancer, is characterized by its remarkable cellular plasticity, enabling tumour cells to switch between different phenotypic states. This plasticity contributes to tumour he...
Alterations in epigenetic marks and expression of genes related to stress regulation: an exploratory study among newborns after fetal repair of spina bifida aperta [0.03%]
与应激调节相关表观遗传位点和基因表达变化的改变：开放性脊柱裂胎儿期手术后新生儿中的探索性研究
M A Landolt,N L Strebel,U Moehrlen et al.
M A Landolt et al.
Fetal repair of spina bifida aperta (fSBA) is an established intervention that improves neurological and neurodevelopmental outcomes. The present exploratory study examines whether molecular signatures related to stress regulation are detec...
Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction [0.03%]
细胞葡萄糖摄取的暂时性增加可加剧压力超负荷诱导的心肌肥厚和心功能障碍
Sayan Bakshi,Samuel F Chang,Luke A Potter et al.
Sayan Bakshi et al.
Clinically prior hyperglycemia may lead to long-lasting adverse cardiovascular effects, a process referred to as 'glycemic memory.' Epigenetic modifications, specifically DNA methylation changes, may play a key role in this phenomenon. This...
Associations of breast DNA methylation-based measures of biological ageing with obesity-related breast cancer risk markers [0.03%]
乳腺DNA甲基化老化标志与肥胖相关乳腺癌风险标记之间的关联研究
Amarnath Singh,Joseph P McElroy,Daniel Y Weng et al.
Amarnath Singh et al.
Advancing age and deregulated obesity are well-established risk factors for breast cancer risk. While epigenetic ageing, a measure of biological ageing, has been linked to breast cancer risk, prior studies have mainly focused on blood-based...
Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases [0.03%]
RNA N5-甲基胞嘧啶修饰在生殖生理和妇科疾病中的作用不容小觑
Fei Lv,Yi Jin,Shuchen Yu et al.
Fei Lv et al.
The epitranscriptome, comprising post-transcriptional RNA modifications, has emerged as a pivotal regulator of gene expression in the female reproductive system. Among these modifications, 5-methylcytosine (m5C) stands out as a widespread a...
Genome-wide DNA methylation profiles and ribosomal DNA copy number at birth [0.03%]
出生时的全基因组DNA甲基化谱和核糖体DNA拷贝数
Kathrin Barth,Rossella Alfano,Michelle Plusquin et al.
Kathrin Barth et al.
Ribosomal DNA copy number (rDNAcn) and DNA methylation are important modulators of the human genome, both studied in relation to overall cellular function, biological ageing, and disease development. Despite the overlapping roles, their rel...
Early characterization of pregnancy glycemic traits in gestational diabetes mellitus by plasma cell-free mRNA and non-coding RNA [0.03%]
妊娠期糖尿病早期妊娠糖代谢特征的无细胞mRNA和非编码RNA标志物研究
Songchang Chen,Yuwei Liu,Tingyu Yang et al.
Songchang Chen et al.
In recent years, the incidence of gestational diabetes mellitus (GDM) has been steadily increasing, posing risks to the long-term health of both mother and child. We aim to characterize blood glucose levels of pregnant women and predict the...
Immune pathways and prenatal/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration [0.03%]
免疫途径和宫内/围产期环境暴露有助于表观遗传学胎龄预测及提前出生
Amy A Eapen,Ian M Loveless,Mingming Pan et al.
Amy A Eapen et al.
DNA methylation (DNAm), capturing chronological gestational age (GA) and epigenetic gestational age acceleration (EGAA), can be modified by environmental exposures. The Asthma&Allergy array is a new DNAm array developed with content focused...
Silencing of optogenetic and chemogenetic transgenes in human iPSCs involves promoter methylation and methylation-independent mechanisms [0.03%]
在人多能干细胞中，光遗传和化学遗传转基因的沉默涉及启动子甲基化和独立于甲基化的机制
Yiwen Wang,Yanyan Li,Jingzhen Li et al.
Yiwen Wang et al.
The transplantation of neural progenitor cells derived from induced pluripotent stem cells (iPSCs) has therapeutic potential for the treatment of neurological diseases. However, the functional integration of transplanted iPSC-derived neuron...
A cell type enrichment analysis tool for brain DNA methylation data (CEAM) [0.03%]
脑DNA甲基化数据的细胞类型富集分析工具（CEAM）
Joshua Müller,Valentin T Laroche,Jennifer Imm et al.
Joshua Müller et al.
DNA methylation (DNAm) signatures are highly cell type-specific, yet most epigenome-wide association studies (EWAS) are performed on bulk tissue, potentially obscuring critical cell type-specific patterns. Existing computational tools for d...