Jamshid Faraji,Gerlinde A S Metz
Jamshid Faraji
Humans have coexisted with dogs for at least 20,000 years, yet the biological consequences of long-term human-dog co-residence remain poorly understood. We propose that sustained exposure to dogs may have contributed to context-dependent va...
LncRNA MIR4435-2HG-mediated succinylation of USF1 promotes its protein stability and induces epithelial-mesenchymal transition in HNSCC [0.03%]
长链非编码RNA MIR4435-2HG介导的USF1琥珀酰化促进其蛋白稳定性和头颈部鳞癌上皮间质转化诱导作用
Shujin He,Jing Wang,Dingding Wang et al.
Shujin He et al.
Tumor recurrence and metastasis remain the principal causes of mortality in patients with head and neck squamous cell carcinoma (HNSCC). However, the key molecular drivers underlying HNSCC progression and their regulatory mechanisms have no...
A relative methylation ordering biomarker of lactylation-related genes predicts prognosis and therapeutic response in cutaneous melanoma [0.03%]
与乳酸化相关的基因相对甲基化排序生物标志物可预测皮肤黑色素瘤的预后和治疗反应
Jiayi Ruan,Lingli Wang,Fukang Liu et al.
Jiayi Ruan et al.
Cutaneous melanoma (CM) is highly invasive with limited prognostic tools, and the prognostic relevance of lactylation, a novel post-translational modification, remains unexplored. We developed a lactylation-related prognostic model using re...
NOS1 hypermethylation may participate in the colorectal cancer development and be associated with its prognosis [0.03%]
NOS1甲基化可能参与结直肠癌的发生发展并影响患者预后
Zhaohui Zhang,Aibuta Yeerken,Xinyao Shao et al.
Zhaohui Zhang et al.
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Although epigenetic alterations are common in CRC, the epigenetic changes that occur during colorectal carcinogenesis remain unclear. Thus, we sought to elucidat...
Development and validation of a digital PCR assay targeting plasma FAR1 methylation for early detection of hepatocellular carcinoma [0.03%]
用于检测肝细胞癌的早期血浆FAR1甲基化数字PCR测定的建立及验证
Sun Jae Park,Yun Young Lee,Yong-Kyu Chung et al.
Sun Jae Park et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, yet current surveillance with alpha-fetoprotein (AFP) and ultrasound (US) lacks sufficient accuracy, particularly for early-stage disease. This study a...
Differential DNA methylation clock ages across buffy coat (BC), peripheral blood mononuclear cells (PBMC), and saliva in individuals in early-to-mid adulthood [0.03%]
不同类型的样本（全血、外周血单个核细胞和唾液）在20到55岁人群中的DNA甲基化年龄差异分析
Ryan Bruellman,Donald Evans,Andrew Smolen et al.
Ryan Bruellman et al.
Epigenetic aging prior to midlife is gaining interest as an intervenable period to address health and cognitive aging. Epigenetic changes may index DNA methylation aging rates, but methylation profiles may not be substitutable across tissue...
Direct and indirect genetic effects of birthweight predisposition on child DNA methylation at birth [0.03%]
出生体重倾向的直接和间接遗传效应影响新生儿DNA甲基化状况
Nicole Creasey,Leonard Frach,Elena Isaevska et al.
Nicole Creasey et al.
Birthweight is heritable and strongly associated with epigenetic differences at birth. It is unclear whether a genetic birthweight score is associated with DNA methylation (DNAm) and, if so, whether through direct genetic effects (i.e. chil...
The role of R-loops-mediated epigenetic regulation in genome stability maintenance and disease pathogenesis: a systematic review [0.03%]
R-loop介导的表观遗传调控在基因组稳定性维持和疾病发生发展中的作用：系统综述
Zi Hao Jiang,Di Feng Wang,Rui Shao et al.
Zi Hao Jiang et al.
This systematic review synthesizes current evidence linking R-loops - associated processes with epigenetic regulation, genome stability, and human disease, integrating findings across DNA/RNA/protein modifications and 3D genome organization...
M6A-dependent regulation of microRNAs from CKD stage 5 patients: insights from epigenetic modification analysis [0.03%]
来自CKD 5期患者M6A依赖性调节的microRNA：从表观遗传修饰分析中获得的新见解
Zhiqian Yang,Fanna Liu,Mingjun Ye et al.
Zhiqian Yang et al.
Chronic kidney disease (CKD) stage 5 is frequently accompanied by systemic inflammation, and peripheral blood mononuclear cells (PBMCs) play an important role. To define the epitranscriptomic features of PBMC small RNAs in CKD stage 5, we p...
Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension [0.03%]
多组学分析揭示了原发性高血压的新致病甲基化位点、基因及潜在调控通路
Xinmeng Hu,Huizhen Jin,Xiaoyang Li et al.
Xinmeng Hu et al.
The complex pathophysiology of essential hypertension (EH) continues to pose challenges to blood control. This study investigated the association of blood DNA methylation and gene expression with EH in blood and arterial tissues to identify...