Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner [0.03%]
母体eNOS缺乏通过性别依赖的方式决定后代脂肪肝表型
Berthold Hocher,Hannah Haumann,Jan Rahnenführer et al.
Berthold Hocher et al.
Maternal environmental factors can impact on the phenotype of the offspring via the induction of epigenetic adaptive mechanisms. The advanced fetal programming hypothesis proposes that maternal genetic variants may influence the offspring's...
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk [0.03%]
血浆中ABCG1和PHOSPHO1位点的DNA甲基化与未来2型糖尿病风险相关
Tasnim Dayeh,Tiinamaija Tuomi,Peter Almgren et al.
Tasnim Dayeh et al.
Identification of subjects with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention of the disease. Consequently, it is essential to search for new biomarkers that can improve the prediction of T2D. The aim of this...
Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome [0.03%]
GDAP1基因DNA甲基化差异的验证及其作为疾病严重程度和治疗效果生物标志物的潜力
Christof Brückmann,Adriana Di Santo,Kathrin Nora Karle et al.
Christof Brückmann et al.
Alcohol dependence is a severe disorder contributing substantially to the global burden of disease. Despite the detrimental consequences of chronic alcohol abuse and dependence, effective prevention strategies as well as treatment options a...
Prognostic impact of epigenetic classification in chronic lymphocytic leukemia: The case of subset #2 [0.03%]
慢性淋巴细胞性白血病亚组患者的预后影响：第2子集案例分析研究
Sujata Bhoi,Viktor Ljungström,Panagiotis Baliakas et al.
Sujata Bhoi et al.
Based on the methylation status of 5 single CpG sites, a novel epigenetic classification of chronic lymphocytic leukemia (CLL) was recently proposed, classifying CLL patients into 3 clinico-biological subgroups with different outcome, terme...
Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio) [0.03%]
双酚A导致繁殖毒性、降低dnmt1转录并减少斑马鱼育种的全球DNA甲基化水平
L V Laing,J Viana,E L Dempster et al.
L V Laing et al.
Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. Previous studies demonstrated that BPA activates estrogenic signaling pathw...
Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach [0.03%]
基于候选miRNA的空气污染诱导早期生命阶段胎盘表观遗传改变
Maria Tsamou,Karen Vrijens,Narjes Madhloum et al.
Maria Tsamou et al.
Particulate matter (PM) exposure during in utero life may entail adverse health outcomes in later-life. Air pollution's adverse effects are known to alter gene expression profiles, which can be regulated by microRNAs (miRNAs). We investigat...
Variations in HDL-carried miR-223 and miR-135a concentrations after consumption of dietary trans fat are associated with changes in blood lipid and inflammatory markers in healthy men - an exploratory study [0.03%]
反式脂肪膳食摄入对血清载HDL-miR-223和HDL-miR-135水平的影响及与血脂、炎症标志物变化的关系：探索性研究
Véronique Desgagné,Simon-Pierre Guay,Renée Guérin et al.
Véronique Desgagné et al.
A high consumption of trans fatty acids (TFAs) is associated with an increased risk of cardiovascular diseases (CVDs). High-density lipoproteins (HDLs) have many cardioprotective properties and transport functional microRNAs (miRNAs) to rec...
Randomized Controlled Trial
Epigenetics. 2016 Jun 2;11(6):438-48. DOI:10.1080/15592294.2016.1176816 2016
Arachidonic and oleic acid exert distinct effects on the DNA methylome [0.03%]
花生四烯酸和油酸对DNA甲基化模式具有不同的影响
Guillermo A Silva-Martínez,Dalia Rodríguez-Ríos,Yolanda Alvarado-Caudillo et al.
Guillermo A Silva-Martínez et al.
Abnormal fatty acid metabolism and availability are landmarks of metabolic diseases, which in turn are associated with aberrant DNA methylation profiles. To understand the role of fatty acids in disease epigenetics, we sought DNA methylatio...
Nucleosome positioning changes during human embryonic stem cell differentiation [0.03%]
人胚胎干细胞分化过程中核小体定位的变化
Wenjuan Zhang,Yaping Li,Michael Kulik et al.
Wenjuan Zhang et al.
Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human emb...
Factors affecting the persistence of drug-induced reprogramming of the cancer methylome [0.03%]
影响药物诱导的癌症甲基组重编程持久性的因素
Joshua S K Bell,Jacob D Kagey,Benjamin G Barwick et al.
Joshua S K Bell et al.
Aberrant DNA methylation is a critical feature of cancer. Epigenetic therapy seeks to reverse these changes to restore normal gene expression. DNA demethylating agents, including 5-aza-2'-deoxycytidine (DAC), are currently used to treat cer...