Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes [0.03%]
正常支气管场基底细胞显示出对烟草烟雾的广泛甲基化影响，包括已知的癌症基因中
Batbayar Khulan,Kenny Ye,Miao Kevin Shi et al.
Batbayar Khulan et al.
Lung carcinogenesis is causally linked to cigarette smoking, in part by epigenetic changes. We tested whether accumulated epigenetic change in smokers is apparent in bronchial basal cells as cells of origin of squamous cell carcinoma. Using...
Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults [0.03%]
多项表观遗传评分与老年美国成年人的心血管代谢风险因素的人口统计学特征和健康行为相互影响
Lisha Lin,Wei Zhao,Zheng Li et al.
Lisha Lin et al.
Poly-epigenetic scores (PEGS) are surrogate measures that help capture individual-level risk. Understanding how the associations between PEGS and cardiometabolic risk factors vary by demographics and health behaviors is crucial for lowering...
METTL14-mediated m6A modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis [0.03%]
METTL14介导的DDIT4mRNA上m6A修饰促进其稳定性并参与特发性肺纤维化中的异常蛋白质翻译调控
Dan Li,Li Qian,Yufeng Du et al.
Dan Li et al.
Although N6-methyladenosine (m6A) may be related to the pathogenesis of fibrotic process, the mechanism of m6A modification in aging-related idiopathic pulmonary fibrosis (IPF) remains unclear. Three-milliliter venous blood was collected fr...
Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines [0.03%]
α-亚麻酸介导的宫颈癌细胞系表观遗传重编程
Amrita Ulhe,Prerna Raina,Amol Chaudhary et al.
Amrita Ulhe et al.
Cervical cancer, the fourth most common cancer globally and the second most prevalent cancer among women in India, is primarily caused by Human Papilloma Virus (HPV). The association of diet with cancer etiology and prevention has been well...
Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC) [0.03%]
SETD2介导的H3K36me3与RNA N6-甲基腺苷在透明细胞肾癌中的互作解析
Shafiq Shaikh,Xia Zhao,Ryan T Wagner et al.
Shafiq Shaikh et al.
RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of VHL followed by mut...
Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress [0.03%]
星形胶质细胞源外泌体通过调节精子miR-34c水平介导父代慢性社会不稳定压力的跨世代效应
Alexandre Champroux,Mitra Sadat-Shirazi,Xuan Chen et al.
Alexandre Champroux et al.
The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce stress-specific phenotypes in their offspring. However, how each stress paradigm alte...
Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA) [0.03%]
基于动脉粥样硬化的多族裔研究（MESA）的表观基因组关联分析在感知歧视方面的作用
Wei Zhao,Lisha Lin,Kristen M Kelly et al.
Wei Zhao et al.
Perceived discrimination, recognized as a chronic psychosocial stressor, has adverse consequences on health. DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and ...
DNA-based cell typing in menstrual effluent identifies cell type variation by sample collection method: toward noninvasive biomarker development for women's health [0.03%]
基于DNA的月经排出物细胞分型发现采样方法决定了细胞类型差异：向非侵入性生物标志物开发迈进以促进女性健康
Irma M Vlasac,Hannah G Stolrow,Zaneta M Thayer et al.
Irma M Vlasac et al.
Menstrual effluent cell profiles have potential as noninvasive biomarkers of female reproductive and gynecological health and disease. We used DNA methylation-based cell type deconvolution (methylation cytometry) to identify cell type profi...
Timing of dietary effects on the epigenome and their potential protective effects against toxins [0.03%]
饮食对表观基因组的影响时间及其潜在的抗毒保护作用
Lynnea A Nicholls,Kendall A Zeile,London D Scotto et al.
Lynnea A Nicholls et al.
Exposure to toxins causes lasting damaging effects on the body. Numerous studies in humans and animals suggest that diet has the potential to modify the epigenome and these modifications can be inherited transgenerationally, but few studies...
Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins [0.03%]
美国中年双胞胎样本中的孤独表观基因组关联研究
Christopher R Beam,Kelly M Bakulski,Ebrahim Zandi et al.
Christopher R Beam et al.
Loneliness is a complex human trait that is highly polygenic and found to affect gene expression related to inflammatory and immunological functioning. To date, no epigenome-wide association studies of loneliness have tested whether differe...