ANRIL upregulates TGFBR1 to promote idiopathic pulmonary fibrosis in TGF-β1-treated lung fibroblasts via sequestering let-7d-5p [0.03%]
ANRIL通过吸附let-7d-5p促进TGF-β1诱导的肺成纤维细胞向特发性肺纤维化表型转化中TGFBR1的上调表达
Weidong Wu,Nanding Yu,Weiming Chen et al.
Weidong Wu et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive and life-threatening respiratory disease characterized by worsening lung function due to excessive scarring. The objective of this study was to investigate the role of the long non-coding...
Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome [0.03%]
急性冠脉综合征患者中饮酒但不吸烟可预测死亡率
Allan Andersen,Steven R H Beach,Willem Philibert et al.
Allan Andersen et al.
The relationship of heavy alcohol consumption (HAC) and smoking to mortality in those with CHD, and mechanisms through which these effects are elicited are not clear. In order to improve our understanding, we examined the relationship of Al...
Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure [0.03%]
孕期铅暴露对小鼠成体组织特异性piRNA表达的影响及性别差异研究
Bambarendage P U Perera,Kai Wang,Dongyue Wang et al.
Bambarendage P U Perera et al.
Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWIL proteins to induce DNA methylation. It remains unknown whether Pb e...
Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting [0.03%]
使用纳米孔测序技术通过颊拭子检测DNA甲基化以研究生长迟缓现象
Alim El-Hakim,Inswasti Cahyani,Muhammad Zulfikar Arief et al.
Alim El-Hakim et al.
Stunting is the result of chronic malnutrition due to the lack of micronutrient-based methyl donors required for epigenetic programming during the first 1000 days of life. Methylation studies using bisulfite conversion from blood DNA are in...
Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis [0.03%]
急性胰腺炎患者外周血DDR1和CtBP基因甲基化检测的临床意义
Zeng-Hui Ma,Xue-Ni Ma,Hong-Wen Zhu et al.
Zeng-Hui Ma et al.
To investigate the clinical value of methylation levels of peripheral blood DDR1 and CtBP genes in evaluating the severity of acute pancreatitis (AP). Collect 90 blood samples from AP patients and healthy volunteers, and test methylation le...
MK-801-exposure induces increased translation efficiency and mRNA hyperacetylation of Grin2a in the mouse prefrontal cortex [0.03%]
MK-801诱导的小鼠前额叶皮质Grin2a翻译效率增强和mRNA过度乙酰化
Liting Xue,Jialu Zhao,Xu Liu et al.
Liting Xue et al.
Acute exposure to MK-801, the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, induces schizophrenia-like behavioural changes in juvenile male mice. However, the effects of acute MK-801 exposure on brain gene expression at t...
Xuegeng Wang,Ramji K Bhandari
Xuegeng Wang
Eggs and sperm are responsible for the continuation of generations. Following the epigenetic reprogramming of the embryo, core epigenetic information present in the sperm and eggs is transmitted to offspring somatic cells prior to the blast...
Parental arsenic exposure and tissue-specific DNA methylation in Bangladeshi infants with spina bifida [0.03%]
父亲砷暴露与孟加拉国脊柱裂婴儿的组织特异性DNA甲基化关系研究
Gwen Tindula,Sudipta Kumer Mukherjee,Sheikh Muhammad Ekramullah et al.
Gwen Tindula et al.
An emerging hypothesis linking arsenic toxicity involves altered epigenetic mechanisms, such as DNA methylation. In this study, we examined the relationship between parents' arsenic exposure and DNA methylation in tissues obtained from 28 i...
Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation [0.03%]
孕期维生素D缺乏的表观基因组元分析及其对脐带血DNA甲基化的影响
Elizabeth W Diemer,Johanna Tuhkanen,Sara Sammallahti et al.
Elizabeth W Diemer et al.
Low maternal vitamin D concentrations during pregnancy have been associated with a range of offspring health outcomes. DNA methylation is one mechanism by which the maternal vitamin D status during pregnancy could impact offspring's health ...
Meta-Analysis
Epigenetics. 2024 Dec;19(1):2413815. DOI:10.1080/15592294.2024.2413815 2024
A promising application of kidney-specific cell-free DNA methylation markers in real-time monitoring sepsis-induced acute kidney injury [0.03%]
肾脏特异性细胞游离DNA甲基化标记物在实时监测脓毒症诱导的急性肾损伤中的应用展望
Ruilian You,Xiangming Quan,Peng Xia et al.
Ruilian You et al.
Sepsis-induced acute kidney injury (SI-AKI) is a common clinical syndrome that is associated with high mortality and morbidity. Effective timely detection may improve the outcome of SI-AKI. Kidney-derived cell-free DNA (cfDNA) may provide n...