CTCF delimits a DNA methylation transition at the intergenic region between the embryonic and adult α-globin genes [0.03%]
CTCF划定胚胎和成人α-球蛋白基因间的间隔区的DNA甲基化状态变化区域
Gustavo Tapia-Urzúa,Hober Nelson Núñez-Martínez,Sylvia Garza-Manero et al.
Gustavo Tapia-Urzúa et al.
Transcriptional activation of cell-type-specific genes is achieved by multiple mechanisms that guarantee chromatin accessibility at cis-regulatory elements and the long-range interactions between them. Generally, DNA methylation counteracts...
Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models [0.03%]
实验模型中与H19 / IGF2：IG-DMR甲基化脱钩的文化依赖性H19等位基因特异性表达
Céline Selenou,Frédéric Brioude,Laure Sudre et al.
Céline Selenou et al.
Genomic imprinting is an epigenetic mechanism leading to the monoallelic expression of a subset of genes, mainly regulated by DNA methylation at imprinting control regions (ICRs). Silver-Russell syndrome (SRS) is a paradigmatic imprinting d...
Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophy [0.03%]
环境线索通过心肌细胞肥大的收缩蛋白基因表达的昼夜节律控制发出信号
Adrian Arrieta,Alexa Jennings,Pratiti Dasgupta et al.
Adrian Arrieta et al.
Environmental disruption alters circadian clock gene expression, increasing the risk of adverse cardiac events and suggesting cardiomyocyte-specific circadian responses to external stimuli. Analyses of previously reported transcriptomic dat...
p53-mediated epigenetic regulation in the pathogenesis of endometriosis [0.03%]
p53介导的表观遗传调控在子宫内膜异位症发病机制中的作用
Jiameng Wang,Qi Liao,Xiaoling Feng
Jiameng Wang
Endometriosis (EMs) is a common gynecological disorder affecting reproductive‑aged women, characterized by ectopic endometrial growth and chronic pelvic pain that severely impairs quality of life. Although its pathogenesis remains incomple...
Decoding osteosarcoma pathogenesis: the pivotal influence of m6A modification [0.03%]
揭秘骨肉瘤发生发展规律：m6A修饰的关键作用
Chaomei Huang,Zhongyu Han,Junyan Su et al.
Chaomei Huang et al.
Osteosarcoma (OS) is the predominant primary malignant bone tumor in children and adolescents. Current treatments mainly include surgical resection combined with chemotherapy, but they still cannot effectively control tumor metastasis and r...
N6-methyladenosine modification of mRNAs in retinal ischemia-reperfusion in mice [0.03%]
缺血再灌注诱导的视网膜mRNA N6-甲基腺苷修饰变化及作用研究
Jingying Liang,Yuke Li,Yuwen Wen et al.
Jingying Liang et al.
Retinal ischemia-reperfusion injury (RIR) is the main pathogenic mechanisms of acute glaucoma, diabetic retinopathy, central retinal vein occlusion. As a common post-transcriptional modification of eukaryotic RNAs, N6-methyladenosine (m6A) ...
Epigenetic regulation of vertebrate limb development: from field specification to tissue morphogenesis [0.03%]
脊椎动物肢体发育的表观遗传调控：从场域分配到组织形态发生
Claudia Monserrat Vallejo-De Lira,Claudio Iván Galván-Hernández,Jesús Chimal-Monroy et al.
Claudia Monserrat Vallejo-De Lira et al.
Vertebrate limb development provides an excellent model for understanding how epigenetic mechanisms coordinate the integration of positional information and temporal signals to generate complex three-dimensional structures. An increasing bo...
Dnmt1 associated Gja1 promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury [0.03%]
Dnmt1相关Gja1启动子甲基化改变与急性心肌缺血/再灌注损伤中Cx43重塑有关
Yang Liu,Zijun Wang,Youxiao Zhao et al.
Yang Liu et al.
DNA methylation has traditionally been regarded as a stable epigenetic modification. However, emerging evidence indicates that oxidative and genotoxic stress can induce locus-specific methylation changes that modulate transcriptional respon...
Differential CpG methylation in the Interferon Gamma (IFNG) promoter correlates with viral load and transcriptional control in people with HIV [0.03%]
HIV感染者干扰素γ（IFNG）启动子区CpG甲基化的差异与病毒载量及转录调控相关性研究
Megha S Srivatsa,Momtahina Tahmida,Tara Tenenbaum et al.
Megha S Srivatsa et al.
HIV persistence is facilitated by immune evasion strategies that reshape host immune responses. As the Interferon Gamma (IFNG) gene encodes a key immunoregulatory cytokine whose transcriptional competence is governed by promoter CpG methyla...
m6A methylation of circKPNA2 promotes colorectal carcinogenesis by activating the RIN1-Ras pathway [0.03%]
circKPNA2的m6A甲基化通过激活RIN1-Ras途径促进结直肠癌发生发展
Jinhai Tian,Zongying Jiang,Qi Huang et al.
Jinhai Tian et al.
Colorectal cancer (CRC) is a prevalent and highly lethal malignancy. However, the molecular mechanisms underlying its progression remain incompletely understood. Therefore, this study aimed to investigate the role and mechanisms of circKPNA...