Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment [0.03%]
基于生物信息学的抗血管生成影响髓源性抑制细胞的关键基因筛选及作用机制分析
XiangFei Zhao,RuGang Zhao,JuYi Wen et al.
XiangFei Zhao et al.
This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor cell (MDSC) infiltration and investigate their mechanisms of action. Data on DEGs after the a...
Design and evaluation of a multiepitope vaccine for pancreatic cancer using immune-dominant epitopes derived from the signature proteome in expression datasets [0.03%]
基于表达数据集中签名蛋白质组的免疫优势表位设计和评估多抗原表位胰腺癌疫苗
Sooram Banesh,Nupoor Patil,Vihadhar Reddy Chethireddy et al.
Sooram Banesh et al.
Pancreatic cancer is a highly aggressive and often lethal malignancy with limited treatment options. Its late-stage diagnosis and resistance to conventional therapies make it a significant challenge in oncology. Immunotherapy, particularly ...
Plumbagin as a preferential lead molecule to combat EGFR-driven matrix abundance and migration of cervical carcinoma cells [0.03%]
白菖亭作为针对EGFR驱动的宫颈癌细胞基质丰度和迁移的优先先导化合物
Sneha Krishnamoorthy,Rajalakshmi Sabanayagam,Loganayaki Periyasamy et al.
Sneha Krishnamoorthy et al.
The handshake between the complex networks of matrix components in the tumor micro-environment (TME) is considered as a crucial event in the progression of several cancers including cervical carcinoma (CC). A number of studies report a conn...
In vitro anticancer activity of Hirudinaria manillensis methanolic extract and its validation using in silico molecular docking approach [0.03%]
Hirudinaria manillensis甲醇提取物的体外抗癌活性及其通过计算机模拟分子对接方法的验证
P Zeebul Trinita Shannan,Susan G Suganya,E Angel Jemima et al.
P Zeebul Trinita Shannan et al.
Cancer has emerged as a potentially lethal illness, which recently upsurged in the mortality rate. Animal-derived compounds could be promising targets with higher efficacy and low toxicity in anticancer therapy. The present study aimed to e...
Role of interferon-induced transmembrane protein family in cancer progression: a special focus on pancreatic cancer [0.03%]
干扰素诱导跨膜蛋白家族在癌症进展中的作用：特别关注胰腺癌
Peipei Wang,Yan Pan,Yu Zhang et al.
Peipei Wang et al.
Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 can be induced by interferon, while IFITM5 and IFITM10 are insensitive to interferon. IFITMs has various functions, in...
High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer [0.03%]
CD9和表皮生长因子受体的高度表达促进舌癌的发展
P C Suhasini,Vadisha Bhat,Shilpa S Shetty et al.
P C Suhasini et al.
Tongue cancer is distinguished by aggressive behavior, a high risk of recurrence, lymph, and distant metastases. Hypoxia-Induced Factor 1 α functions as a CD9 transcription factor. CD9 is a transmembrane protein that may be found on the ce...
The cytotoxic effects of prazosin, chlorpromazine, and haloperidol on hepatocellular carcinoma and immortalized non-tumor liver cells [0.03%]
哌唑嗪，氯丙嗪和卤OPERIDOL对肝癌细胞和永生化非肿瘤肝细胞的细胞毒性作用
Seth Harris,Prithvi Nagarajan,Kyoungtae Kim
Seth Harris
Liver cancer annually accounts for over 800,000 cases and 700,000 deaths worldwide. Hepatocellular carcinoma is responsible for over 80% of liver cancer cases. Due to ineffective treatment options and limited surgical interventions, hepatoc...
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator [0.03%]
HDAC抑制作为化疗增敏剂和表观遗传调节因子在癌症治疗中新兴的治疗策略
Dipanjan Karati,Swarupananda Mukherjee,Souvik Roy
Dipanjan Karati
In developing new cancer medications, attention has been focused on novel epigenetic medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer behavior is being advanced by research on epigenetics, which also suppl...
Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway [0.03%]
Navitoclax（Bcl-2和Bcl-xL抑制剂）与Debio-0932（Hsp90抑制剂）的组合通过诱导凋亡信号通路抑制前列腺癌细胞的活力
Aydemir Asdemir,Aykut Özgür
Aydemir Asdemir
Prostate cancer is one of the most common cancers in men. Given the diverse nature of prostate cancer and its tendency to respond differently to various treatments, combination therapies are often employed to enhance outcomes. In this study...
An effective treatment approach of liposomally encapsulated metformin in colon cancer [0.03%]
封装二甲双胍的有效治疗方法在结肠癌中的应用研究
Enis Cetin,Olcay Boyacioglu,Seda Orenay-Boyacioglu
Enis Cetin
Metformin is a drug that is widely used in the treatment of type-2 diabetes and its anticarcinogenic effect has been detected in many studies since the 2000s. Metformin has a short half-life and poor biocompatibility, which limits the activ...