Structure-based multitargeted docking screening, pharmacokinetics, DFT, and dynamics simulation studies reveal mitoglitazone as a potent inhibitor of cellular survival and stress response proteins of lung cancer [0.03%]
基于结构的多靶点对接筛选、药代动力学、DFT及动力学模拟研究揭示出米妥唑作为肺癌细胞生存和应激反应蛋白的强力抑制剂
Abdulkarim S Binshaya,Omar Saad Alkahtani,Fahad M Aldakheel et al.
Abdulkarim S Binshaya et al.
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is ...
Effect of capecitabine as monotherapy for HER2 normal metastatic breast cancer [0.03%]
卡培他滨单药治疗HER2阴性转移性乳腺癌的效果
Anne-Dorthe Mosgaard Knudsen,Mikala Wej Modvig,Marianne Vogsen et al.
Anne-Dorthe Mosgaard Knudsen et al.
This study aimed to evaluate the efficacy of capecitabine monotherapy for patients with human epidermal growth factor receptor-2 (HER2) normal metastatic breast cancer (MBC). The primary endpoint was progression-free survival (PFS), and sec...
YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis [0.03%]
YWHAG通过调节CTTN-Wnt/β-catenin信号轴促进结直肠癌进展
Yuanben Wang,Yulin Cao,Ying Chen et al.
Yuanben Wang et al.
Colorectal cancer (CRC) ranks as the third most prevalent cancer type globally. Nevertheless, the fundamental mechanisms driving CRC progression remain ambiguous, and the prognosis for the majority of patients diagnosed at an advanced stage...
Potential role of immune cell therapy in gynecological cancer and future promises: a comprehensive review [0.03%]
免疫细胞疗法在妇科肿瘤中潜在作用及未来前景：综述文章
Sandipan Dasgupta,Sakuntala Gayen,Tania Chakraborty et al.
Sandipan Dasgupta et al.
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer ce...
Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach [0.03%]
丙酮酸钠和雷公藤醇联合抗胶质母细胞瘤作用的研究：一种新的治疗方法
Bahar Kartal,Farika Nur Denizler-Ebiri,Mustafa Güven et al.
Bahar Kartal et al.
Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) in two glioblasto...
Estrogen-receptor status determines differential regulation of α1- and α2-adrenoceptor-mediated cell survival, angiogenesis, and intracellular signaling responses in breast cancer cell lines [0.03%]
雌激素受体状态决定乳腺癌细胞系中α1和α2肾上腺素受体介导的细胞生存，血管生成及信号转导反应的不同调控
Hannah P Priyanka,Uday P Pratap,Rahul S Nair et al.
Hannah P Priyanka et al.
Psychosocial stress promotes cancer pathogenesis involving angiogenesis through alterations in neuroendocrine-immune functions that may involve adrenoceptor (AR)-dependent signaling mechanisms in the brain, lymphoid organs, and cancerous ce...
Physical characterization and bioavailability assessment of 5-fluorouracil-based nanostructured lipid carrier (NLC): In vitro drug release, Hemolysis, and permeability modulation [0.03%]
基于纳米结构的类脂载体（NLC）的5-氟尿嘧啶的物理特征及生物利用度评估：体外药物释放、溶血和通透性调节
Mainuddin,Anoop Kumar,Ratneshwar Kumar Ratnesh et al.
Mainuddin et al.
5-Fluorouracil (5-FU) is an anticancer agent belonging to BCS Class III that exhibits poor release characteristics and low retention in the biological system. The main objective of this investigation was to develop a drug delivery system, i...
Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing [0.03%]
单细胞RNA测序在高TP53表达骨肉瘤细胞肿瘤微环境中的细胞通讯及信号通路研究
Kai Xiong,Yuqi Fang,Boyuan Qiu et al.
Kai Xiong et al.
Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in unsatisfactory outcomes, particularly for metastatic cases. The tumor microenvironment (TME) h...
Shakeel Hussain,Yilei Guo,Yu Huo et al.
Shakeel Hussain et al.
Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the phosphorylation of lots of substrates, including STAT3, p53, JAK2, PTEN, RELA, and AKT, leading to the regulation of diabetes, cardiovascular diseases, ...
The efficacy and safety of PD-1 inhibitor combined with TACE in the first-line treatment of unresectable hepatocellular carcinoma [0.03%]
PD-1抑制剂联合TACE一线治疗不可切除肝细胞癌的疗效及安全性评估
Qing-Qing Liu,Xiang-Xu Wang,Hongchen Ji et al.
Qing-Qing Liu et al.
The application of immune checkpoint inhibitors (ICIs) has changed the treatment of advanced hepatocellular carcinoma. Transcatheter arterial chemoembolization (TACE) is a first-line treatment for intermediate hepatocellular carcinoma. Serv...