Highlighting the role of long non-coding RNA (LncRNA) in multiple myeloma (MM) pathogenesis and response to therapy [0.03%]
长链非编码RNA在多发性骨髓瘤发病机制和治疗反应中的作用不容忽视
Sulieman Ibraheem Shelash Al-Hawary,Saade Abdalkareem Jasim,Farag M A Altalbawy et al.
Sulieman Ibraheem Shelash Al-Hawary et al.
Transcripts longer than 200 nucleotides that are not translated into proteins are known as long non-coding RNAs, or lncRNAs. Now, they are becoming more significant as important regulators of gene expression, and as a result, of many biolog...
Salvianolic acid B inhibits the growth and metastasis of A549 lung cancer cells through the NDRG2/PTEN pathway by inducing oxidative stress [0.03%]
salvianolic酸B通过诱导氧化应激来抑制A549肺癌细胞的生长和转移的NDRG2/PTEN途径
Ye Yang,Lei Huang,Jie Gao et al.
Ye Yang et al.
Salvianolic acid B (Sal B) has demonstrated anticancer activity against various types of cancer. However, the underlying mechanism of Sal B-mediated anticancer effects remains incompletely understood. This study aims to investigate the impa...
Urinary extracellular vesicle-derived miR-126-3p predicts lymph node invasion in patients with high-risk prostate cancer [0.03%]
尿液外泌体衍生的miR-126-3p用于高危前列腺癌淋巴结侵犯的预测价值
Liang Dong,Cong Hu,Zehua Ma et al.
Liang Dong et al.
To investigate extracellular vesicles (EVs), biomarkers for predicting lymph node invasion (LNI) in patients with high-risk prostate cancer (HRPCa), plasma, and/or urine samples were prospectively collected from 45 patients with prostate ca...
Focused cancer pathway analysis revealed unique therapeutic targets in retinoblastoma [0.03%]
聚焦的癌症信号通路分析揭示了视网膜母细胞瘤中的独特治疗目标
Sekaran Balaji,Anindita Rao,Karuvel Kannan Saraswathi et al.
Sekaran Balaji et al.
Retinoblastoma (RB) is a pediatric cancer of the eye that occurs in 1/15000 live births worldwide. Albeit RB is initiated by the inactivation of RB1 gene, the disease progression relies largely on transcriptional alterations. Therefore, eva...
Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21 [0.03%]
白藜芦醇纳米颗粒通过p53非依赖型活化p21干扰CTNNB1和GLI-1相互作用诱导口腔癌干细胞发生凋亡
Subhasmita Bhal,Biswajit Das,Saptarshi Sinha et al.
Subhasmita Bhal et al.
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and progression are regulated by multiple signaling cascades including Wnt/β-catenin and Hh/GLI-1, which acts independen...
p200CUX1-regulated BMP8B inhibits the progression of acute myeloid leukemia via the MAPK signaling pathway [0.03%]
P200CUX1通过调节BMP8B抑制MAPK信号通路从而抑制急性髓系白血病的发展进展
Meng Wang,Liang Zhong,Hongyan Zhang et al.
Meng Wang et al.
The full-length p200CUX1 protein encoded by the homology frame CUT-like protein (CUX1) plays an important role in tumors as a pro-oncogene or oncogene. However, its role and mechanism in acute myeloid leukemia remain unknown. p200CUX1 regul...
Decitabine suppresses MDSC-induced immunosuppression through dual functional mechanism and inhibits melanoma metastasis [0.03%]
地西他滨通过双重功能机制抑制MDSC诱导的免疫抑制并抑制黑色素瘤转移
Zhonghai Zhang,Tianlong Wang,Gaochuan Fang et al.
Zhonghai Zhang et al.
Myeloid-derived suppressor cells (MDSCs) play a crucial role in promoting melanoma metastasis. Reprogramming MDSCs into mature M1 macrophages has emerged as a strategy to inhibit metastasis. Decitabine (Dec) is known to eradicate MDSCs and ...
The recent update and advancements of natural products in targeting the Wnt/β-Catenin pathway for cancer prevention and therapeutics [0.03%]
近期天然产物在靶向Wnt/β-Catenin信号通路预防和治疗癌症方面的发展及进展
Lunasmrita Saikia,Bhaskarjyoti Gogoi,Saikat Sen et al.
Lunasmrita Saikia et al.
The Wnt/β-Catenin pathway (Wnt/β-CatP) is implicated in accelerating carcinogenesis and cancer progression, contributing to increased morbidity and treatment resistance. Even though it holds promise as a focus for cancer treatment, its in...
P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway [0.03%]
P4HA2通过PI3K/AKT信号通路促进头颈鳞癌进展和上皮间质转化
Yan-Ling Wu,Wan Liu,Tingting Zhao et al.
Yan-Ling Wu et al.
Head and neck squamous cell carcinoma (HNSCC) can be defined as a deadly illness with a dismal prognosis in advanced stages. Therefore, we seek to examine P4HA2 expression and effect in HNSCC, along with the underlying mechanisms. This stud...
Dermaseptin B2 bioactive gene's potential for anticancer and anti-proliferative effect is linked to the regulation of the BAX/BBC3/AKT pathway [0.03%]
Dermaseptin B2生物活性基因的抗癌和抗增殖作用与BAX/BBC3/AKT通路调控相关
Fatemeh Khak-Rah Nasirabadi,Abbas Doosti
Fatemeh Khak-Rah Nasirabadi
Dermaseptin B2 (DrsB2) is an antimicrobial peptide with anticancer and angiostatic properties. We aimed to assess the in vitro inhibitory effect of pDNA/DrsB2 on the growth of breast cancer cells and its impact on the expression of genes in...