GRIN3A defines an immunosuppressive niche in advanced prostate cancer [0.03%]
GRIN3A定义了晚期前列腺癌中的免疫抑制生态位
Xinglin He,Yaohua Hu,Zhite Zhao et al.
Xinglin He et al.
Early-stage prostate cancer is typically manageable with standard therapies, yet the eventual development of castration-resistant prostate cancer (CRPC) remains a significant barrier to effective clinical management. Specifically, the respo...
Evaluation of the effects of silver nanoparticles and ciprofloxacin on apoptotic gene expression (BAX, Bcl-2, and caspase-3) in NALM-6 acute lymphoblastic leukemia progenitor B cells [0.03%]
银纳米颗粒和环丙沙星对NALM-6急性淋巴细胞白血病前体B细胞凋亡基因表达(BAX,Bcl-2和caspase-3)影响的评价研究
Mojtaba Aghaei,Arshid Yousefi-Avarvand,Najmaldin Saki et al.
Mojtaba Aghaei et al.
Acute lymphoblastic leukemia (ALL), classified as a lymphoid neoplasm under the WHO 5th Edition Haematolymphoid Tumours system, is characterized by uncontrolled proliferation of immature B-cell precursors. Nanotechnology-based therapies are...
Extracellular vesicles-mediated communication between glioblastoma and astrocytes promotes pro-tumorigenic activation [0.03%]
胶质母细胞瘤和星形胶质细胞之间的细胞外囊泡介导的通信促进促肿瘤活化
Ezgi Taskan,Oguz Kaan Kirbas,Batuhan Turhan Bozkurt et al.
Ezgi Taskan et al.
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, classified by the WHO as grade IV astrocytoma, with poor prognosis and limited treatment options. Extracellular vesicles (EVs) are lipid bilayer nanopartic...
Targeted delivery of venetoclax-encapsulated human heavy chain ferritin nanoparticles in acute myeloid leukemia [0.03%]
人源重链铁蛋白纳米颗粒包封的维奈克拉特在急性髓系白血病中的靶向递送
Mohadeseh Khodaverdian,Misagh Rajabinejad,Reza Valadan et al.
Mohadeseh Khodaverdian et al.
Venetoclax (VEN) is a B-cell lymphoma 2 (BCL-2) inhibitor approved for treatment in acute myeloid leukemia (AML). Human heavy chain ferritin (HFn) is a bio-inspired nanoparticle (NP) utilized to deliver multiple chemotherapies to tumor cell...
Exosome-based strategies and immunotherapy for skin cancer: mechanisms, challenges, and future directions [0.03%]
外泌体在皮肤癌免疫治疗中的作用及机制挑战和未来方向
Hafez Karimi,Nima Seifollahi,Parnian Yavari et al.
Hafez Karimi et al.
Skin cancer continues to be among the top malignancies diagnosed around the world, with rising incidence through the years. The cause of most deaths is the metastatic progression, which commonly limits the success of the treatments availabl...
Farnesol induces apoptosis, LC3B/SQSTM1 mediated regulation of autophagy and downregulates anaerobic Glycolysis through suppression of LDH and PKM in A549 lung adenocarcinoma cells [0.03%]
法尼醇通过抑制LDH和PKM下调A549肺腺癌细胞的糖酵解并诱导LC3B / SQSTM1介导的自噬调节及细胞凋亡
Nagakanni Muthuvenugopal,Sangita Behera,Soundarya Rani Rajendra Kumar et al.
Nagakanni Muthuvenugopal et al.
Non-small cell lung cancer (NSCLC) is a metabolism associated disease which mainly depends on anaerobic glycolysis to produce the macromolecules needed for biosynthesis and rapid cell proliferation. Since the cancer cells depend on glycolys...
LncRNA TMPO-AS1 aggravates the cisplatin resistance in cervical cancer via miR-140-5p/DNMT1 axis-mediated DNA methylation of KLK10 [0.03%]
长链非编码RNA TMPO-AS1通过miR-140-5p/DNMT1轴介导的DNA甲基化调节KLK10促进顺铂耐药性宫颈癌的发展
Jian Yang,Zhouhong Shi,Ting Song et al.
Jian Yang et al.
Cisplatin resistance severely limits the efficacy of chemotherapy for cervical cancer (CC), and its molecular mechanisms remain incompletely understood. While epigenetic alterations such as DNA methylation are recognized as important contri...
Ashwagandha (Withania somnifera) targets liver cancer stem cells via inhibiting Hedgehog signaling pathway in hepatocellular carcinoma [0.03%]
阿育吠陀草药冬梨根靶向肝癌干细胞抑制 Hedgehog 信号通路在肝细胞癌中的作用
Samah E Ismail,Amany I Youssef,Esraa E Fawzy et al.
Samah E Ismail et al.
Ashwagandha (W. somnifera), known for its broad health benefits, has shown potential in cancer prevention and treatment. The aim of this study was to investigate the potential effect of ashwagandha aqueous extract (ASH-AE) on cell prolifera...
Extracellular vesicles in colorectal cancer: immunomodulation, diagnostics, and therapeutic perspectives [0.03%]
肠癌的细胞外囊泡：免疫调节、诊断和治疗前景
Ridhiksha Kumra,Rohit Rai,Raman Thakur
Ridhiksha Kumra
Colorectal cancer (CRC) remains a significant global health concern and is among the leading causes of cancer-related mortality. The disease often progresses to more advanced and treatment-resistant stages. By 2040, the incidence of CRC is ...
Updates on niosomes in interfering nucleic acid delivery for cancer treatment: A comprehensive review and future perspectives [0.03%]
用于癌症治疗的干扰核酸传递的新型尼奥斯OM更新：全面回顾和未来展望
Reena Gupta,Haneen Fadhil Jasim,Zahraa Abbas Al-Khafaji et al.
Reena Gupta et al.
Cancer continues to be one of the top killers worldwide. Traditional treatment strategies like chemotherapy, radiation, and surgery have non-specific treatment options with considerable side effects. Gene-based therapies using nucleic acids...