Natural simple coumarins and their interaction with AKR1C3: implications for overcoming chemoradioresistance in gastrointestinal carcinomas [0.03%]
具有天然结构简单香豆素及其与AKR1C3的相互作用：克服消化道肿瘤放化疗抵抗性的潜力
Zahra Nasiri Sarvi,Hamid Gholamhosseinian,Mehrdad Iranshahi et al.
Zahra Nasiri Sarvi et al.
Gastrointestinal (GI) carcinomas are among the leading cause of cancer-related deaths worldwide, and chemoradioresistance severely limits the long-term effectiveness of their treatment. Aldo-keto reductase family 1 member C3 (AKR1C3) is a t...
Hippo-YAP/TAZ signaling in gastric cancer: molecular pathogenesis and emerging therapeutic horizons [0.03%]
斑马鱼-YAP / TAZ信号在胃癌中的作用：分子病理和治疗前景
Mandeep Kaur,Rachel Fabian Mungurere,Noah Mitinje et al.
Mandeep Kaur et al.
Gastric cancer remains a significant global health challenge, ranking as the 5th most common cancer worldwide with high mortality rates. Despite advances in diagnostic and therapeutic approaches, the prognosis for advanced gastric cancer re...
Structural and functional insights into CD3 bispecific antibodies targeting DLL3 in cancer immunotherapy [0.03%]
针对癌症免疫治疗CD3双特异性抗体（靶向DLL3）的结构和功能见解
Shanshan Chen,Guangshun Zhang,Xiangyi He et al.
Shanshan Chen et al.
CD3 bispecific antibodies (BsAbs) targeting delta-like ligand 3 (DLL3) have emerged as promising candidates in cancer immunotherapy by enabling T-cell-mediated tumor lysis. A critical unmet need is to establish structural correlates of thei...
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression [0.03%]
一种三氟甲基喹啉衍生物通过靶向SGK1并调节PI3K / AKT途径来抑制前列腺癌的发展和进展
Xianhui Yang,Rui Wang,Guangcan Xu et al.
Xianhui Yang et al.
Prostate cancer (PCa) is one of the most prevalent malignant tumors among men globally, with limited treatment options, especially in cases that progress to castration-resistant prostate cancer (CRPC). Identifying novel molecular targets an...
Investigating the effects of platelets, platelet releasate and aspirin on colorectal cancer cell proliferation, migration and invasion [0.03%]
血小板、血小板释放产物和阿司匹林对结直肠癌细胞增殖、迁移和侵袭的影响研究
David Capraro,David Ewan Connor,Joanne Emily Joseph
David Capraro
The aims of this study were to investigate the binding of platelets to colorectal cancer (CRC) cells, platelet activation by CRC cells, and determine the effect of platelets and platelet releasate containing extracellular vesicles on CRC ce...
MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinoma [0.03%]
口腔鳞状细胞癌中的微小核糖核酸介导的信号转导及代谢重编程
Gunjankumari Patel,Sitaram Harihar
Gunjankumari Patel
Oral Squamous Cell Carcinoma (OSCC) is the most aggressive oral cancer type, with minimal survival rates resulting from metastases and disease recurrence. Early detection and innovative treatment approaches are required to limit metastases ...
Gecko protein F2 inhibits tumor angiogenesis by suppressing the VEGF/MAPK/ERK signaling pathway [0.03%]
Gecko蛋白F2通过抑制VEGF/MAPK/ERK信号通路抑制肿瘤血管生成
Huaying Jiang,Huihui Wang,Xue Wei et al.
Huaying Jiang et al.
The anti-tumor clinical effect of traditional Chinese medicine gecko is very prominent. A novel anti-tumor protein component F2 was isolated and purified from geckos by our group, and the aim of this study was to investigate its antitumor e...
CD168 in lung adenocarcinoma: prognostic relevance, immune feature associations, and MAPK/ERK pathway enrichment [0.03%]
肺腺癌中的CD168：预后意义、免疫特征关联及MAPK/ERK通路富集
Meihan Liu,Kexin Luo,Yaoshu Song et al.
Meihan Liu et al.
Lung adenocarcinoma (LUAD), the predominant non-small cell lung cancer (NSCLC) subtype, faces major clinical challenges including poor prognosis and acquired drug resistance. This study integrates multi-omics analyses with in vitro function...
A randomized clinical trial assessing the efficacy of vitamin B prophylaxis in attenuating paclitaxel-induced neuropathy and the imperative use of gabapentin in diabetic ovarian cancer patients [0.03%]
维生素B预防宁泌特诱发的周围神经病变的临床疗效评估及糖尿病卵巢癌患者使用加巴喷丁的必要性研究
Mahitab Haggagy,Fatma Raslan,Norhan El Said et al.
Mahitab Haggagy et al.
Paclitaxel being an effective treatment for ovarian cancer, presents one of the most critical toxicities; peripheral neuropathy (PN), a debilitating side effect that might limit continuation of chemotherapy. Vitamin B was found to significa...
Randomized Controlled Trial
Medical oncology (Northwood, London, England). 2026 Feb 6;43(3):141. DOI:10.1007/s12032-026-03252-3 2026
Smart covalent organic frameworks in cancer sensing and imaging: opportunities, challenges, and translational prospects [0.03%]
智能共价有机框架在癌症检测和成像中的机会、挑战和转化前景
Abdullah Sadeq Amer,Bassam Z Shakhreet,Seham Sulieman-Alhemaidi et al.
Abdullah Sadeq Amer et al.
Covalent organic frameworks (COFs) represent a rapidly expanding class of porous crystalline materials with exceptional potential in cancer diagnosis and therapy. Their ordered π-conjugated backbones, tunable pore architectures, and abunda...