Shuaixing An,Zhaojin Yu,Jianping Li et al.
Shuaixing An et al.
Elbasvir triggers ferroptosis in esophageal squamous cell carcinoma through NCOA4-mediated ferritinophagy [0.03%]
Elbasvir通过NCOA4介导的铁死亡诱导食管鳞状细胞癌中铁蛋白自噬触发铁死亡
Maoju Tang,Feng Gong,Miyuan Yang et al.
Maoju Tang et al.
Esophageal squamous cell carcinoma (ESCC) remains treatment-resistant; we explored Elbasvir, an NS5A inhibitor, as a ferroptosis inducer. Cell viability was assessed by CCK-8 assays. Apoptosis and cell cycle were analyzed via flow cytometry...
Engineered mesenchymal stem cells expressing CXCR4 and LIGHT enhance Anti-Tumor activity in a subcutaneous gastric cancer xenograft model [0.03%]
表达CXCR4和LIGHT的间充质干细胞通过基因工程改造后能够增强在皮下胃癌异种移植模型中的抗肿瘤活性
Umer Anayyat,Jianbin Ye,Xumin Wu et al.
Umer Anayyat et al.
Gastric cancer remains a leading cause of cancer-related mortality, with limited treatment options and a poor prognosis. Mesenchymal stem cells (MSCs) possess inherent tumor-homing ability but exhibit modest efficacy against solid tumors. E...
Loss of junctional plakoglobin (JUP) activates PI3K/AKT signaling in head and neck squamous cell carcinoma [0.03%]
连接处斑珠蛋白(JUP)丢失激活头颈鳞状细胞癌中的PI3K/AKT信号转导
Marius Hörner,Natalie Burkard,Babak Saravi et al.
Marius Hörner et al.
Head and neck squamous cell carcinomas (HNSCC) are characterized by poor prognosis, primarily due to early metastatic spread. The junctional plaque protein plakoglobin (JUP), a key desmosomal component, contributes not only to cell-cell adh...
Maleimide-substituted 1,4-naphthoquinone flaviolin mimetic (FM7) induces S-phase arrest and mitochondria-mediated apoptosis in multiple myeloma cells [0.03%]
马来酰亚胺取代的1,4-萘醌黄酮类似物（FM7）可诱导多发性骨髓瘤细胞S期阻滞和线粒体介导的凋亡
Samriti Saklani,Ashish Sahu,Akhil Karandikar et al.
Samriti Saklani et al.
Effective treatment for multiple myeloma remains a significant clinical challenge due to multidrug resistance and the side effects of current chemotherapies, indicating the need for new interventions. Flaviolin, a 1,4-naphthoquinone derivat...
Bio-mediated synthesis of zinc oxide nanoparticles from Crossandra infundibuliformis leaves: A potent inducer of apoptosis in lung cancer cells [0.03%]
来自Crossandra infundibuliformis叶子的生物合成的氧化锌纳米颗粒：肺癌细胞凋亡的强力诱导剂
Akshaya Priya Raveendran,G Ragavendran,S Jayashri et al.
Akshaya Priya Raveendran et al.
Zinc oxide nanoparticles (ZnO-NPs) have gained attention as potential anticancer agents due to their selective cytotoxicity and ability to induce apoptosis. In this study, we evaluated the anticancer efficacy and apoptotic mechanism of bios...
Metronomic chemotherapy in resource-limited settings: evidence, opportunities, and future directions [0.03%]
资源匮乏条件下使用序贯化疗的证据、机遇及发展方向
Atul Kumar Gupta
Atul Kumar Gupta
Metronomic chemotherapy-frequent, continuous delivery of low-dose chemotherapeutic drugs without drug-free breaks-is a promising treatment option for resource-limited situations. This narrative review analyzes the scientific justification, ...
Pharmacological modulation of Ca²⁺ signaling by calycosin promotes glioblastoma cell death [0.03%]
锦灯笼素通过药理学上调节钙离子信号促进胶质母细胞瘤细胞凋亡
Lyh-Jyh Hao,Chiang-Ting Chou,Tzu-Ying Sung et al.
Lyh-Jyh Hao et al.
Retraction Note: Alternative use of Droxidopa for treating cervical cancer: inhibiting transferase, cell cycle signalling, and transport proteins via multitarget docking, DFT, MD simulations, and binding free energy studies [0.03%]
撤回 notice:多药耐药性治疗宫颈癌的替代药物：通过多靶点对接、DFT、MD模拟和结合自由能研究抑制转移酶、细胞周期信号传导和转运蛋白
Saleh Hussain A Almasabi,Hassan H Almasoudi,Hassan Albargy et al.
Saleh Hussain A Almasabi et al.
Phytochemical and pharmacological elucidation of Jasonia glutinosa (L.) fourr. essential oil: a promising therapeutic source against inflammation and cancer [0.03%]
Jasonia glutinosa(L.)fourr.精油的植物化学和药理学研究：一种有前景的抗炎及抗癌治疗资源
Abdellah Baraich,Amine Elbouzidi,Mounir Haddou et al.
Abdellah Baraich et al.
The growing demand for natural therapeutics with safer pharmacological profiles has renewed interest in aromatic plants traditionally used in folk medicine. Jasonia glutinosa (L.) Fourr. (Asteraceae), commonly known as "sticky fleabane", is...