Site-specific trastuzumab Fab-DM1 via butelase-1 with ABD fusion for potent HER2-positive tumor control [0.03%]
一种通过Butelase 1与ABD融合实现的定点特异性的抗HER2肿瘤高效控制疗法Fab-DM1疗法
Yiming Han,Qi Guo,Han Cao et al.
Yiming Han et al.
Antibody-drug conjugates (ADCs) are constrained by limited tumor penetration of IgG formats and heterogeneity from stochastic conjugation. We addressed these challenges by engineering a compact trastuzumab Fab-based ADC with site-specific i...
Unraveling the link between genomic instability and tumor immune evasion in oral squamous cell carcinoma: Role of CBMN assay and emerging perspectives [0.03%]
解开基因组不稳定与口腔鳞状细胞癌肿瘤免疫逃逸之间联系的纽带：微核检测的作用和前景展望
Asad Ullah,Gulbeena Saleem
Asad Ullah
Oral squamous cell carcinoma (OSCC), being the most common malignancy of head and neck origin, corelates with genomic instability (GI) through increased consumption of carcino-genotoxic substances. Elevated consumption of tobacco, betel qui...
Novel patient-derived tongue squamous cell carcinoma cell lines from non-smokers: 3D and in vivo models for drug response studies [0.03%]
新型舌鳞状细胞癌患者源性细胞系：用于药物反应研究的非吸烟者来源的三维和体内模型
Graziella Ribeiro de Sousa,Guilherme da Silva Carvalho,Bruna Miyoko Ikenaga de Brito et al.
Graziella Ribeiro de Sousa et al.
Tongue squamous cell carcinoma (TSCC) is the most prevalent and aggressive subtype of oral squamous cell carcinoma (OSCC), with a high incidence of lymph node metastasis even in early stages. The five-year overall survival rates remain low,...
Decoy oligonucleotide technology in cancer therapy: molecular mechanisms, challenges, and translational potential [0.03%]
癌症治疗中的诱饵寡核苷酸技术：分子机制、挑战及转化潜力
Maryam Mahjoubin-Tehran,Samaneh Rezaei,Prashant Kesharwani et al.
Maryam Mahjoubin-Tehran et al.
Decoy oligonucleotide technology has emerged as a promising molecular strategy for cancer therapy by selectively inhibiting transcription factor binding to genomic DNA and thereby blocking oncogenic signalling at the pre-transcriptional lev...
The translational roles of circular RNAs in cancers and their underlying molecular mechanisms [0.03%]
circRNA在癌症中的翻译作用及其潜在分子机制研究进展
Xinxin Wu,Xiaohan Ye,Huiling Chen et al.
Xinxin Wu et al.
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalently closed circular structure. They can be divided into nuclear-encoded circRNAs (nuc-circRNAs) and mitochondria-encoded circular RNAs (mecciRNAs). For the nu...
Targeting and monitoring cancer cells with cold atmospheric plasma and PET Imaging: a new theranostic approach [0.03%]
冷等离子体和PET成像检测癌症细胞的新诊疗方法及其应用监测
Shokoufeh Karimi,Hasan Mehdian,Shahzad Feizi et al.
Shokoufeh Karimi et al.
Cold atmospheric plasma (CAP) has emerged as a promising tool for biomedical applications, including cancer research. In this study, we developed a micro‑sized CAP device designed for minimally painful subdermal plasma delivery in BALB/c m...
Chromatin chronicles: Unlocking the therapeutic potential of histone modifiers in hepatocellular carcinoma [0.03%]
染色质编年史：解锁组蛋白修饰剂在肝细胞癌治疗中的潜力
Muhammad Sulaiman,Ziyi Chen,Yimin Nie et al.
Muhammad Sulaiman et al.
Hepatocellular carcinoma (HCC) represents the primary liver cancer among adults with diverse tissue appearance, high disease severity, and negative treatment expectancy. The molecular heterogeneity, extensive invasion, and propensity for re...
MALAT1 promotes autophagy via the mir-28-5p/IGF1R axis in nasopharyngeal carcinoma [0.03%]
MALAT1通过mir-28-5p/IGF1R轴促进鼻咽癌的自噬作用
Xiaopeng Huang,Yunxiu Luo,Jiawei Chen et al.
Xiaopeng Huang et al.
The long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is implicated in cancer progression, yet its precise mechanism in nasopharyngeal carcinoma (NPC), particularly its interaction with microRNAs and its ro...
Antitumor effect of the AP5Z1 small-molecule inhibitor PGG in hepatocellular carcinoma [0.03%]
PGGG，一种AP5Z1小分子抑制剂的抗肿瘤效果评估：肝细胞癌模型中的研究
Zhipeng Quan,Qianxin Hu,Mingjiang Liu et al.
Zhipeng Quan et al.
In this study, small-molecule inhibitors targeting AP5Z1 were developed, and their antitumor activity against hepatocellular carcinoma (HCC) and related mechanisms were evaluated. Candidate molecules were initially screened via computer-aid...