Single-cell profiling reveals lineage-specific fibroblast stromal subtypes drive ECM remodeling and immune modulation in the hepatocellular carcinoma tumor microenvironment [0.03%]
单细胞测序揭示肝癌肿瘤微环境基质成纤维细胞亚群的异质性及其免疫调控功能
Zhichao Jiang,Haitao Wang,Han Li et al.
Zhichao Jiang et al.
HCC is characterized by extensive ECM remodeling, primarily mediated by stromal cells. While cancer-associated fibroblasts are known contributors to tumor fibrosis, their transcriptional diversity and role in immune modulation within the HC...
Derazantinib enhances gemcitabine efficacy in PDAC by attenuating the NF-κB and MAPK pathways to suppress MUC5AC expression [0.03%]
Derazantinib通过抑制NF-κB和MAPK通路来降低MUC5AC表达从而增强PDAC中吉西他滨的疗效
Wenkai Ye,Yiyun Huang,Lue Hong et al.
Wenkai Ye et al.
Pancreatic ductal adenocarcinoma (PDAC) is usually treated with gemcitabine (GEM)-based chemotherapy. However, resistance to GEM develops frequently. Aberrant fibroblast growth factor receptors (FGFR) signaling in PDAC is linked to advanced...
Girdin silencing enhances mebendazole-mediated anticancer activity: a combinatorial therapeutic strategy for ovarian cancer [0.03%]
GRIDIN基因沉默增强梅苯哒唑介导的抗癌活性：卵巢癌综合治疗策略
Rahul Gupta,Yasmin Begum,Dipanjan Ghosh et al.
Rahul Gupta et al.
Ovarian cancer is among the deadliest gynecological malignancies due to its aggressive nature and limited treatment options. Mebendazole (MBZ), a known antiparasitic drug, has shown anticancer activity in several cancer types, though its me...
Autophagy-Apoptosis synchronization: A mechanism of black grape anthocyanins mediated chemosensitization of 5-FU in HepG2 hepatocellular carcinoma cells [0.03%]
自噬和凋亡的同步化：黑葡萄花色苷介导的5-FU化疗增敏作用机制研究 HepG2肝癌细胞系模型
Zofa Shireen,Samrat Saha,Ujjal Das et al.
Zofa Shireen et al.
Hepatocellular carcinoma (HCC) continues to be a significant cancer in India, exhibiting a yearly incidence of about 1.6%. The limitations of conventional chemotherapy, such as systemic toxicity and drug resistance, highlight the need of na...
Investigation of the possible effects of LncRNA CYTOR on the molecular mechanisms of metastasis and Hippo signaling pathways in Triple-negative and Cisplatin-resistant breast cancer cell lines [0.03%]
长链非编码RNA CYTOR对三阴性和顺铂耐药乳腺癌细胞系转移及Hippo信号通路的分子机制的影响研究
Emine Erdağ,Emel Ergene,Fatma Yıldız
Emine Erdağ
Breast cancer is one of the cancers with the highest incidence among women worldwide. Increasing evidence suggests that the long noncoding RNA cytoskeleton regulator (CYTOR) plays a critical role in cancers and is upregulated in many cancer...
RNA-guided STAT3 modification fine tunes the epigenetic and epitranscriptomic regulation of CD4 + T helper cell differentiation during non-small cell lung cancer (NSCLC) [0.03%]
RNA引导的STAT3修饰可调节非小细胞肺癌中CD4+T辅助细胞分化过程中的表观遗传和表遗传调控
Roshni Bibi,Melvin George,Koustav Sarkar
Roshni Bibi
The accurate control of immune responses in the tumor microenvironment is crucial for augmenting anti-cancer immunity. This work examined the function of STAT3 in modulating epigenetic and epitranscriptomic pathways during the differentiati...
Crosstalk between microRNA and oxidative stress in ovarian cancer: diagnosis, pathogenesis and therapeutic resistance [0.03%]
卵巢癌中微小核糖核酸与氧化应激的串扰：诊断、发病机制和治疗抵抗性
Amany Gomaa Atiaa,Shehab M Abd E-Kader,Doha El-Sayed Ellakwa
Amany Gomaa Atiaa
Ovarian cancer (OC) is the most lethal gynecologic malignancy due to late-stage diagnosis, frequent recurrence, and resistance to therapy. Emerging evidence highlights oxidative stress (OS)-a redox imbalance caused by excessive reactive oxy...
A therapeutic approach of LC-MS characterised MFER-Mc against alcohol and NDEA induced hepatocellular carcinoma activity through LXR-α, LXR-β and HMG-CoA pathway: an in-silico, in-vitro and in-vivo study [0.03%]
一种针对酒精和NDEA诱导的肝细胞癌活性的MFER-Mc治疗途径通过LC-MS表征，涉及LXR-α、LXR-β和HMG-CoA途径：一项基于计算机模拟、体外和体内研究的结果
Shashi Ranjan,Priyashree Sunita,Shakti P Pattanayak
Shashi Ranjan
Ethanol was previously classified as a co-carcinogen or tumour promoter, based on early animal studies. Ethanol may also contribute to cancer development indirectly by serving as a solvent for chemical constituents found in tobacco smoke, f...
"Exosomal blueprint of lung-tropic metastasis: molecular signatures, microenvironmental conditioning, and translational implications in cancer" [0.03%]
“肺癌转移的外泌体蓝图：分子特征、微环境调节和癌症中的转化意义”
Noura A A Ebrahim,Thoraya A Farghaly,Soliman M A Soliman
Noura A A Ebrahim
Exosomes are increasingly recognized as central regulators of organ-specific metastasis, and this review concentrates on their contribution to lung-directed dissemination. Yet, a detailed and integrative synthesis of how exosomes contribute...
Role of Aldo-Keto reductase family 1 member C in cancer progression: a special focus on the role of AKR1C1 in pancreatic cancer [0.03%]
醛酮还原酶家族1成员C在癌症进展中的作用：特别关注醛酮还原酶家族1成员C1在胰腺癌中的作用
Degao Huang,Heyang Zhang,Yu Zhang et al.
Degao Huang et al.
AKR1Cs, as a reductase enzyme family, play a pro-carcinogenic role in various types of cancers, including hormone-related malignancies and non-hormonal tumors. However, there exists a notable scarcity of literature concerning AKR1Cs express...