Takeshi Takahashi
Takeshi Takahashi
Hesperidin nanoparticle therapy confers renoprotection and antitumor effects in Ehrlich ascites carcinoma via coordinated regulation of oxidative stress, Bax/caspase-3, and NF-κB/VEGF pathways [0.03%]
芸香素纳米颗粒通过协同调节氧化应激、Bax/caspase-3和NF-κB / VEGF通路对艾氏腹水癌的肾脏保护和抗肿瘤作用
Mohammed Saleh Alfawaz,Ekramy M Elmorsy,Ayat B Al-Ghafari et al.
Mohammed Saleh Alfawaz et al.
From glycolytic signatures to patients: A translational roadmap for reproducible, equitable deployment of multi-omics and AI in colorectal cancer [0.03%]
从糖酵解特征到患者：可重复、公平地部署多组学和人工智能于结直肠癌的转化路线图
M Vijayasimha
M Vijayasimha
Recent advances in Medical Oncology highlight the integration of bulk and single-cell transcriptomics to reveal glycolytic heterogeneity in colorectal cancer. Translating these discoveries into reliable clinical tools requires rigorous meth...
Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets [0.03%]
百里香酚和氯喹协同抑制黑色素瘤的转移：关于凋亡作用及分子靶点的体外和基于计算机的研究
Patrycja Kłos,Siarhei Dabravolski,Magdalena Perużyńska et al.
Patrycja Kłos et al.
The development of drug resistance remains a major obstacle in the treatment of metastatic melanoma, necessitating novel therapeutic strategies. Combining natural compounds with agents that disrupt cancer cell survival mechanisms, such as a...
Venetoclax combined with ML385 overcomes chemotherapy resistance in acute myeloid leukemia by modulating Nrf2/ARE-mediated oxidative stress [0.03%]
维奈克拉联合ML385通过调节Nrf2/ARE介导的氧化应激克服急性髓系白血病化疗耐药性
Long Zhao,Yuancheng Guo,Jinli Jian et al.
Long Zhao et al.
This study aimed to investigate the potential of Venetoclax combined with ML385 to overcome drug resistance in leukemia cells and the related mechanisms. Analysis of Nrf2 expression and its prognostic significance in AML was performed utili...
Intracellular and exosomal miR-101-3p regulated by METTL14 confers Gefitinib sensitivity in NSCLC [0.03%]
METTL14调节的intracellular和exosomal miR-101-3p可使NSCLC对吉非替尼敏感
Qinglong Kong,Ling Wu,Jun Li et al.
Qinglong Kong et al.
Gefitinib Resistance (GR) is a frequent occurrence for non-small cell lung cancer (NSCLC). Here, we aim to explore a novel miR-101-3p shuttled by NSCLC cells in the growth and metastasis of NSCLC cells. Real-time PCR was performed to assess...
Epigenetic Inhibition of HDAC7 by Daidzein isolated from Macrotyloma uniflorum: A potential therapeutic approach in leukemia in silico, in-vitro and in-vivo [0.03%]
Macrotyloma uniflorum 植物中分离得到的大豆异黄酮的表观遗传抑制HDAC7作用：一种潜在的体内和体外联合计算机辅助的白血病治疗方法
Amber Rizwan,Yeshfeen Sherwani,Zaid Siddiqui et al.
Amber Rizwan et al.
Leukaemia remains a critical haematologic malignancy, where current therapies offer limited efficacy and are frequently associated with significant toxicity. Epigenetic dysregulation, particularly aberrant histone deacetylase (HDAC) activit...
The role of glycoproteins in autophagy and apoptosis in colorectal cancer: A scoping review [0.03%]
糖蛋白在结直肠癌自噬和凋亡中的作用：综述性研究
Asma Ali Ibrahim Mze,Amirah Abdul Rahman,Mohammad Johari Ibahim et al.
Asma Ali Ibrahim Mze et al.
Colorectal cancer (CRC) is one of the most prevalent and deadliest cancers worldwide. Despite current treatments, therapeutic resistance remains a paramount challenge. Glycoproteins play essential roles in cellular processes and have been l...
Phyllanthus niruri potentiates apoptosis in Huh-7 cells and mitigates diethylnitrosamine-induced hepatocarcinogenesis via Hippo-YAP pathway modulation [0.03%]
Phyllanthus niruri通过调节Hippo-YAP途径增强Huh-7细胞凋亡并缓解二乙基亚硝胺诱导的肝癌发生
Annapoorna Bangalore Ramachandra,Madan Kumar Perumal
Annapoorna Bangalore Ramachandra
Hepatocellular carcinoma is one of the deadliest cancers occurring worldwide. Substantial evidence suggests that the Hippo-YAP pathway as a promising therapeutic target. Phyllanthus niruri is known for pharmacological activities, including ...
Adaphostin-induced oxidative stress in oesophageal neuroendocrine carcinoma: a potential therapeutic strategy [0.03%]
适应性后素诱导的食管神经内分泌癌氧化应激：潜在的治疗策略
Chelsea Penney,Ann-Katrin Piper,Jacqueline Holliday et al.
Chelsea Penney et al.
Advanced oesophageal neuroendocrine carcinoma (ENEC) is a highly aggressive and rare malignancy with poor prognosis. Due to the rarity of this cancer there are currently no standardised treatment regimens for ENEC, and models to study this ...