Combination of sodium pentaborate pentahydrate, curcumin and piperine treatment induces ferroptosis in hepatocellular carcinoma cells by regulating iron homeostasis and ROS activity in vitro [0.03%]
五水偏硼酸钠、姜黄素和胡椒碱联合治疗通过调节体外铁稳态和ROS活性诱导肝癌细胞铁死亡
Nurdan Sena Degirmenci,Zarife Yildirim,Gamze Padar et al.
Nurdan Sena Degirmenci et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent solid cancers with the highest mortality rate, despite various treatment modalities. Sodium pentaborate pentahydrate (NaB) is a boron derivative that has an effect on cell death pa...
The upregulated RNA circ_0060055 regulates the proliferation, invasion and apoptosis of pancreatic cancer cells through spongy miR-1298-5p [0.03%]
circRNA circ_0060055通过海绵吸附miR-1298-5p正向调控胰腺癌细胞的增殖、侵袭和凋亡
Liguo Hao,Qiangqiang Yin,Jianing Song et al.
Liguo Hao et al.
In recent studies, circ_0060055, a newly identified circRNA with implications in oncology, was examined for its expression levels in pancreatic cancer cells versus normal pancreatic tissue, utilizing RT-qPCR. This circRNA was evaluated for ...
Two-stage inertial microfluidics enrichment of activated T-cells towards a bead-less chimeric antigen receptor manufacturing protocol [0.03%]
一种不含磁珠的CAR生产新工艺：基于惯性微流体技术的T细胞分选富集
Mona T Elsemary,Michelle F Maritz,Louise E Smith et al.
Mona T Elsemary et al.
CAR-T cell therapy is leading the way in the field of cancer cell immunotherapies due to its high success rates. However, the manufacturing of CAR-T cells remains complex and expensive. T-cell enrichment from patient apheresis starting mate...
Thioredoxin-Binding protein 2 and apoptosis Signal-Regulating kinase 1: redox stress sensors and therapeutic targets in hepatocellular carcinoma [0.03%]
硫氧还蛋白结合蛋白2和凋亡信号调节激酶1：肝细胞癌中的氧化应激感受器和治疗靶点
Nishat Afroz,Arif Ahmad,Abul Vafa et al.
Nishat Afroz et al.
Hepatocellular carcinoma (HCC) develops under sustained oxidative and inflammatory stress, where thioredoxin-binding protein 2 (TBP2/TXNIP) and apoptosis signal-regulating kinase 1 (ASK1/MAP3K5) act as central redox sensors. Under basal con...
Glycyrrhizin upregulates PTEN and suppresses oncogenic signaling in breast cancer [0.03%]
甘草甜素通过上调PTEN并抑制致癌信号传导来治疗乳腺癌
Moneeb Ashraf,Usman Aftab,Tasleem Akhtar et al.
Moneeb Ashraf et al.
Breast cancer progression is driven by aberrant signaling pathways that include proliferation, apoptosis, and cytoskeletal remodeling. While tamoxifen remains central to breast cancer therapy, its clinical utility is restricted by developin...
Evaluation of agmatine's anti-cancer efficacy in Caco-2 colorectal adenocarcinoma cells [0.03%]
_agmatine对Caco-2结肠腺癌细胞的抗癌效果评估_
Esra Guzel Tanoglu,Muhammed Said Gokce,Miray Karamese et al.
Esra Guzel Tanoglu et al.
This study aimed to evaluate the potential effects of agmatine on cell viability, migration, invasion, apoptosis, and the expression of the ABCB1, ABCC1, and ABCG2 genes in the Caco-2 colon cancer cell line. Agmatine efficacy was assessed t...
Mechanisms of astragalus polysaccharide enhancing STM2457 therapeutic efficacy in m6A-mediated OSCC treatment [0.03%]
黄芪多糖通过m6A介导的机制增强STM2457治疗OSCC疗效的作用机制研究
Xi Wang
Xi Wang
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with poor prognosis due to therapeutic resistance and tumor heterogeneity. N6-methyladenosine (m6A) modification, mediated by methyltransferase-like 3 (METTL3), drives OSCC progr...
Ray X Lee
Ray X Lee
Neuronal excitatory activity promotes glioma progression through glutamate-mediated signaling, yet effective ways to counter this using intrinsic brain mechanisms remain undefined. Repeated low-frequency neuronal stimulation can lead to glu...
Targeting thymidylate synthase enhances CD8 + T-cell infiltration and inhibits tumor growth in cervical cancer [0.03%]
叶酸拮抗剂联合免疫治疗可增强宫颈癌免疫应答及治疗效果
Yongyan Pei,Zheng Zhong,Hongliang Li et al.
Yongyan Pei et al.
Cervical cancer (CESC) presents a significant clinical challenge, primarily due to an incomplete understanding of the immunometabolic crosstalk within the tumor microenvironment (TME) and the lack of reliable biomarkers for immunotherapy st...
Correction to: CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression [0.03%]
Correction to: CEBPA调节SOS1活性从而调控ERK1/2并促进卵巢癌进展
Jiahong Tan,Daoqi Wang,Aiqing Tu et al.
Jiahong Tan et al.