SnRNA-seq Interprets Mechanisms by which Three Glial Cell Types Influence Myelin Regeneration in Adult Drug-Resistant Epilepsy-Related Cognitive Impairment [0.03%]
snRNAseq 解析三种胶质细胞类型如何影响成人难治性癫痫相关认知障碍的髓鞘再生机制
Lu Wang,Jia-Qi Ma,Yong-Qian Bian et al.
Lu Wang et al.
Myelin regeneration has been shown in previous studies to ameliorate varying degrees of cognitive impairment in patients with neurodegenerative disorders such as epilepsy. The problem of myelin regeneration in adults with drug-resistant sta...
Mechanisms of Alcohol Interference with Hippocampal Neurogenesis and its Repair Strategies [0.03%]
酒精对海马神经发生干扰的作用机制及其修复策略
Jinghan Wang,Tianxiang Zhang,Ziang Gao et al.
Jinghan Wang et al.
The hippocampus is the central target of alcohol-induced neurotoxicity in impairing memory function, with neurogenesis inhibition being its primary mechanism of action. Alcohol interference with hippocampal neurogenesis is closely associate...
REST/NRSF Regulation of Epilepsy and Cognitive Impairment: Mechanisms and EEG Correlations [0.03%]
REST/NRSF调控癫痫和认知障碍的机制及其与脑电图的相关性研究
Liang OUyang,Xiao-Xuan Li,Bing Li
Liang OUyang
This study aimed to investigate the relationship between REST/NRSF and cognitive impairment in epilepsy, focusing on EEG alterations and serum REST/NRSF levels as potential biomarkers. Additionally, the study explored how REST/NRSF regulati...
Retraction Note to: Human Mesenchymal Stem Cells from Adipose Tissue Differentiated into Neuronal or Glial Phenotype Express Different Aquaporins [0.03%]
撤回 notice: 来自脂肪组织的人间质干细胞分化为神经元或胶质表型表达不同的水通道蛋白
Rosanna Avola,Adriana Carol Eleonora Graziano,Giovanna Pannuzzo et al.
Rosanna Avola et al.
Elevated Acetylation of MFN2 is Accompanied by the Disruption of Mitochondrial Energy Metabolism and Inflammation in a Mouse Model of Depression [0.03%]
抑郁症小鼠模型中MFN2乙酰化升高伴线粒体能量代谢和炎症紊乱
Xiaoxian Xie,Mengya Zhang,Haosheng Xu et al.
Xiaoxian Xie et al.
Mitofusin-2 (MFN2) is recognized as an important regulator of mitochondrial function. The activity of MFN2 is increased by deacetylation, but while MFN2 levels have been reported to be increased in major depressive disorder, the relationshi...
Evaluating the Predictive Value of Oxylipins for Cognitive Measures and White Matter Hyperintensities in Alzheimer's Disease Continuum Compared to Conventional Beta‑amyloid and Tau Protein Biomarkers [0.03%]
与传统的β淀粉样蛋白和tau蛋白生物标志物相比，欧雷利平对阿尔茨海默病谱系中认知测量和白质高信号的预测价值评估
Alireza Shaabanpoor Haghighi,Mahsa Mayeli,Elham Ramezannezhad et al.
Alireza Shaabanpoor Haghighi et al.
Oxylipins are signaling molecules that result from the oxidation of long-chain polyunsaturated fatty acids, and they have been attracting attention due to their potential use as biomarkers for the early detection of Alzheimer's disease (AD)...
Multiple Mechanisms and Therapeutic Strategies for the Involvement of AMPK in the Development of Alzheimer's Disease [0.03%]
AMPK在阿尔茨海默病发病机制中的多效作用及治疗策略
Lin Yu,Xue Yang,Hui-Ping Lei et al.
Lin Yu et al.
Alzheimer's disease (AD) is a major cause of dementia, a life-threatening condition for which there is currently no cure. Currently, the treatment of AD focuses on reducing the accumulation of amyloid β-protein (Aβ) and the phosphorylatio...
Ubiquitination in the Nervous System: From Molecular Mechanisms to Disease Implications [0.03%]
泛素化与神经系统：从分子机制到疾病意义
Yan Xue,Xiaoshan Liu,Xiao Chen et al.
Yan Xue et al.
The ubiquitin‒proteasome system (UPS) comprises ubiquitin, various enzymes, and the proteasome, which are collectively responsible for selectively regulating protein degradation within the human body. Ubiquitination plays a crucial role in...
Integrative Single-Cell Analysis Decodes Gene Expression and Chromatin Accessibility in the Developing Human Fetal Brain [0.03%]
整合单细胞分析解码人类胎儿大脑发育过程中的基因表达和染色质可及性
Tiantian Xu,Huihui Tao,Lingling Zhou et al.
Tiantian Xu et al.
The brain is the core of the central nervous system, responsible for regulating and integrating various physiological and psychological functions. Abnormal disruptions in genes during brain development can lead to a range of neurodevelopmen...
Fermented Soybean Pulp Alleviates Disease Progression of 5×FAD Model Mice [0.03%]
发酵大豆果渣可缓解5×FAD模型小鼠的疾病进展
Chun-Yen Yang,Yu-Hsuan Liu,Ta-Chun Lin et al.
Chun-Yen Yang et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder of the central nervous system, characterized by memory loss and cognitive decline. The two main hypotheses regarding AD involve the accumulation of amyloid-β (Aβ) form...