Quercetin Alleviates Postoperative Cognitive Dysfunction of Aged Mice by Regulating Microglial Polarization through Inducing miR-379-5p RNA Modification [0.03%]
檞皮素通过诱导miR-379-5p的RNA修饰调节小胶质细胞极化来缓解老龄小鼠术后认知功能障碍
Shu Rong Li,Long Wang,Yi Wei Li et al.
Shu Rong Li et al.
Postoperative cognitive disorder (POCD) is a frequent complication after surgery, especially in older patients. Quercetin is a multifunctional natural active ingredient with significant potential in antioxidation, anti-inflammatory and neur...
Anchoring ALS Prognosis: Neurofilament Light Chain Outperforms Inflammatory, Metabolic, and CNS Barrier Biomarkers in the METABALS Cohort [0.03%]
METABALS队列中的神经丝轻链生物标志物优于炎症、代谢和中枢神经系统屏障生物标志物以锚定肌萎缩侧索硬化症的预后
Hugo Alarcan,Charlotte Veyrat-Durebex,Pierre-François Pradat et al.
Hugo Alarcan et al.
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder with marked biological heterogeneity. Despite extensive research, reliable prognostic biomarkers remain limited, with neurofilament light chai...
m6A Modification Genetic Variants Associated with Autism Spectrum Disorder Risks [0.03%]
与自闭症光谱障碍相关的m6A修饰基因变异体
Haoxue Wang,Shuai Zhao,Yanlin Chen et al.
Haoxue Wang et al.
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increasing prevalence and high heritability. As a key epigenetic mechanism in brain development and function, the specific mechanisms of N6-methyladenosine (m6A) modificat...
Mitochondrial-Inflammatory Axis Dysregulation Triggers Disulfidptosis and the Multifaceted Protective Mechanism of Bisphenol A Following Spinal Cord Injury [0.03%]
线粒体-炎症轴失调触发多硫化物依赖的细胞死亡及双酚A对脊髓损伤后的多重保护机制研究
Zixing Xu,Zhechen Li,Xinhao Huang et al.
Zixing Xu et al.
Spinal cord injury (SCI) often leads to significant neurological impairment and poses a substantial therapeutic challenge, with disulfidptosis recently identified as a potential mechanism exacerbating such pathologies. This study examined t...
Apolipoprotein E Deficiency Attenuates Neuroinflammatory Responses and Demyelination in Experimental Autoimmune Encephalomyelitis [0.03%]
载脂蛋白E缺乏可减弱实验性自身免疫性脑脊髓炎中的神经炎症反应和脱髓鞘病变
Xiaohui Lin,Xilin Wu,Xinyi Guo et al.
Xiaohui Lin et al.
The precise etiology of multiple sclerosis (MS) remains incompletely understood, despite a well-established genetic predisposition. Clinical and epidemiological studies have identified an association between apolipoprotein E (ApoE) and MS p...
Differences in Neurofilament Light Chain, Glial Fibrillary Acidic Protein, and Tau Protein Levels in Patients with Temporal Lobe Epilepsy and Comorbid Depression [0.03%]
颞叶癫痫伴抑郁患者的神经丝轻链、胶质纤维酸性蛋白和tau蛋白水平差异分析
Ziting Kong,Junling Fu,Huazheng Luo et al.
Ziting Kong et al.
This study aimed to compare plasma levels of glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau 181 (p-Tau181), and phosphorylated tau 217 (p-Tau217) among patients with temporal lobe epilepsy with c...
CELF2-dependent RNA Regulation Supports Cortical Architecture and Synaptic Stability During Early Brain Development [0.03%]
CELF2依赖的RNA调控支持早期大脑发育中的皮质结构和突触稳定性
Ishana Syed,Jing Jiang,Su-Hyuk Ko et al.
Ishana Syed et al.
RNA regulation plays a central role in neurodevelopment by coordinating neuronal differentiation, migration, and circuit formation. The CUGBP Elav-like family member 2 (CELF2) is an RNA-binding protein with established roles in alternative ...
Metabolic Competition Between Microglia and Neurons as Driver of Chronic Pain [0.03%]
小胶质细胞和神经元之间的代谢竞争是慢性疼痛的驱动因素
Enso O Torres Alegre,Diana E Mora Jiménez
Enso O Torres Alegre
Chronic pain is traditionally framed as a consequence of neuroinflammation and maladaptive synaptic plasticity, with activated microglia releasing cytokines, chemokines, and growth factors that sensitize nociceptive circuits in the spinal d...
Ghrelin Ameliorates Alzheimer's Disease-Associated Astrocyte Dysfunction via UCP2-Mediated Inhibition of FOXO1 Nuclear Translocation [0.03%]
胃激素通过UCP2介导的FOXO1核转位抑制改善阿尔茨海默病相关的星形胶质细胞功能障碍
Yaoxue Guo,Xueyan Wang,Lixiang Zhang et al.
Yaoxue Guo et al.
Alzheimer's disease (AD) is associated with mitochondrial dysfunction and impaired energy metabolism in astrocytes. Although ghrelin is known to exert neuroprotective effects, the mechanisms through which it modulates astrocyte bioenergetic...
PRDX2 Mediates the Neuroprotective Role of Umbilical Cord Blood Exosomes via the CYP2J2/8,9-EET Pathway in Models of Parkinson's Disease [0.03%]
脐带血外泌体通过CYP2J2 / 8,9-EET途径介导Parkinson病模型中的神经保护作用：PRDX2的中介作用
Jingjing Weng,Dianbao Zuo,Wei Yan et al.
Jingjing Weng et al.
Parkinson's disease (PD) is a severe neurodegenerative disorder marked by progressive dopaminergic loss, oxidative stress, metabolic dysregulation, and neuroinflammation. Umbilical cord blood-derived exosomes (UCB-Exos) have emerged as a pr...