Evaluation of 5-hydroxytryptamine (5-HT) on Cognitive Function in Rats with Gut-Brain Axis Dysfunction Following Acceleration Exposure [0.03%]
评价5-羟色胺(5-HT)对模拟失重环境下海马肠脑轴功能障碍大鼠认知功能的影响
Yuqi Chen,TianzhuTao,Andong Zhao et al.
Yuqi Chen et al.
To investigate how 5-hydroxytryptamine (5-HT) modulates acceleration-induced gut-brain axis dysfunction (10 gravitational acceleration [Gz]) and its cognitive impacts in rats, focusing on microbiota-immune interactions and hippocampal neuro...
Protective Effects of Deinoxanthin on Brain Oxidative Damage and Gut Microbiota in the D-Galactose-Induced Aging Mice [0.03%]
虾青素对D-半乳糖诱导衰老小鼠脑氧化损伤及肠道菌群的影响
Huijuan Su,Yutao Li,Jiayi Wan et al.
Huijuan Su et al.
Deinoxanthin (DX), a special hydroxylated tetraterpenoid synthesized by Deinococcus radiodurans, exhibits robust antioxidative activities in vitro and in vivo. The accumulation of excessive reactive oxygen species (ROS) and free radicals in...
Neurochemical Insights into the Role of Tryptophan Metabolites and Kynurenine Pathway in Insomnia and its Psychological and Neurological Comorbidities [0.03%]
色氨酸代谢产物和犬尿酸途径在失眠及其心理和神经共病中的作用的神经化学见解
Wedad S Sarawi
Wedad S Sarawi
Insomnia is a ubiquitous complaint among many people worldwide, significantly impacting cognition, mood, and overall well-being. Despite significant advances made to understand and manage insomnia, shortcomings of its therapeutic interventi...
mTOR-Mediated Protection Against Atrazine-Induced Ferroptosis and Dopaminergic Neurodegeneration in Parkinson's Disease Models [0.03%]
雷酸盐诱导的帕金森病模型中铁死亡和多巴胺能神经元退化的mTOR介导保护作用
Xiaojuan Chen,Zeiyu Du,Huimin Shen et al.
Xiaojuan Chen et al.
Atrazine (ATR) is a widely used herbicide known to induce degeneration of nigrostriatal dopaminergic (DA) neurons, leading to a Parkinson's disease (PD)-like syndrome. Ferroptosis, an iron-dependent non-apoptotic cell death, is implicated i...
Reduced Availability of Essential Amino Acids Disrupts Differentiation of Anorexigenic POMC Neurons in the Fetal Rat Hypothalamus [0.03%]
必需氨基酸的可用性降低会破坏胎儿下丘脑厌食神经元POMC的分化
Pieter Vancamp,Isabelle Grit,Marie Demonceaux et al.
Pieter Vancamp et al.
Intrauterine growth restriction (IUGR) is associated with an elevated risk of long-term metabolic disorders, including obesity and type 2 diabetes, aligning with the Developmental Origins of Health and Disease hypothesis. However, the mecha...
Peripheral Blood Mononuclear Cell Mitochondrial Bioenergetics Is Impaired in De Novo Parkinson's Disease [0.03%]
帕金森病患者的外周血单核细胞线粒体生物能量代谢障碍
Samantha Varada,Amber L Prasad,Brenna M Lobb et al.
Samantha Varada et al.
Mitochondrial dysfunction is increasingly recognized as a key driver of pathology in patients with Parkinson's disease (PD). Peripheral blood mononuclear cells (PBMCs) have emerged as an accessible way to characterize mitochondrial function...
Decoding the Gut Microbiota in Multiple Sclerosis Using Nanopore Long-Read Sequencing: Insights into Disease Severity and Subtypes [0.03%]
使用纳米孔长读序技术解码多发性硬化症的肠道微生物组：对疾病严重程度和亚型的见解
Ameera Saeed Alshinnawy,Elham A Badiea,Mahmoud Saad Swelam et al.
Ameera Saeed Alshinnawy et al.
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS), characterized by neuroinflammation and neurodegeneration. Emerging evidence links gut microbiota dysbiosis to immune dysregulation and MS progressi...
Deciphering Molecular and Signaling Pathways of Extracellular Vesicles-Based Therapeutics for Alzheimer's Disease [0.03%]
解码基于细胞外囊泡的治疗性分子和信号通路以治疗阿尔茨海默病
Rishika Dhapola,Sneha Kumari,Prajjwal Sharma et al.
Rishika Dhapola et al.
The rapidly growing aging population and increasing risk of Alzheimer's disease (AD) necessitate the development of more effective therapeutic strategies. Extracellular vesicles (EVs) have emerged as a promising therapeutic avenue for AD. E...
Correction to: Artesunate Protected Blood-Brain Barrier via Sphingosine 1 Phosphate Receptor 1/Phosphatidylinositol 3 Kinase Pathway After Subarachnoid Hemorrhage in Rats [0.03%]
Correction to：.artesunate通过S1P受体1/pi3k信号通路保护蛛网膜下腔出血后血脑屏障
Shilun Zuo,Hongfei Ge,Qiang Li et al.
Shilun Zuo et al.
Published Erratum
Molecular neurobiology. 2025 Jul 17. DOI:10.1007/s12035-025-05207-7 2025
Disrupted Lipid Metabolism Aggravates Ischemic Brain Injury: Targeting FDFT1 for Stroke Therapy [0.03%]
紊乱的脂质代谢加剧缺血性脑损伤：针对FDFT1的卒中治疗
Jing Yuan,Yu-Sha Liao,Tie-Chun Zhang et al.
Jing Yuan et al.
Lipid metabolism disorder has been established as a contributing factor to the exacerbation of ischemic stroke (IS) damage. Conditions such as metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis are known to...