Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain [0.03%]
突变tau和α-突触核蛋白在神经元的共表达促进Tau磷酸化、神经元丢失及小鼠大脑神经炎症反应
Yuki Yamamoto,Toshiki Kubota,Daisuke Noguchi et al.
Yuki Yamamoto et al.
Intracellular aggregation and accumulation of protein is a hallmark of neurodegenerative diseases. Tauopathy, which is caused by aggregated tau accumulation, is a group of neurodegenerative diseases, including frontotemporal dementia (FTD),...
Neuroprotective and Antidepressant Effects of Isorhamnetin: Mechanistic Evaluations in a Reserpine-Induced Mouse Model of Pain and Depression [0.03%]
异鼠李素的神经保护和抗抑郁作用：低剂量蛇根素诱导的小鼠疼痛和抑郁症模型中的机制研究
Abdelrahim Alqudah,Esam Qnais,Yousra Bsieso et al.
Abdelrahim Alqudah et al.
Depression and pain are frequently comorbid and interact to produce a more difficult clinical picture and decreased response to therapy. Isorhamnetin, a naturally occurring flavonoid, has been suggested to exert an impact on oxidative stres...
Brain Region-Specific Accumulation of Amyloidosis-Associated Proteins in Postmortem Brain Tissues of Alzheimer's Disease Patients [0.03%]
阿尔茨海默病患者死后脑组织中淀粉样蛋白相关蛋白的脑区特异性沉积
Wangchen Tsering,Jennifer L Philips,Todd E Golde et al.
Wangchen Tsering et al.
Numerous extracellular matrix (ECM) proteins, referred to as the matrisome, are increased in Alzheimer's disease (AD). We recently demonstrated that many of these proteins colocalize with Aβ plaques and cerebral amyloid angiopathy (CAA), a...
The Yeast Parkinson's Disease Model Exhibits An Increase in Peroxisome Number Independent of the Division Proteins Vps1 and Dnm1 [0.03%]
酵母帕金森病模型中过氧化物酶体数量增加独立于分裂蛋白VPS1和DNM1
Tanveera Rounaque Sarhadi,Neha Joshi,Shirisha Nagotu
Tanveera Rounaque Sarhadi
Aggregation of α-Synuclein is a hallmark characteristic of Parkinson's disease. Several mutant variants of α-Synuclein linked to the disease that exhibit distinct patterns of localization, aggregation dynamics, and cellular toxicity have ...
Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models [0.03%]
橄榄提取物苦橄榄素衍生物影响帕金森模型中α-突触核蛋白聚集及神经保护作用
Milo J Basellini,José M Granadino-Roldán,Pablo V Torres-Ortega et al.
Milo J Basellini et al.
Α-synuclein aggregation is the pathological feature of several neurodegenerative disorders, including Parkinson's disease. The aggregates can diffuse within brain areas, and their toxicity has been proven in both cellular and animal models...
Defining the Cis-Regulatory Elements of SCN1A in GABAergic Interneurons [0.03%]
定义GABA能中间神经元中SCN1A的顺式调控元件
Joachim Luginbühl,Anika V Prabhu,Chi Wai Yip et al.
Joachim Luginbühl et al.
Dravet syndrome (DS) is a severe neurodevelopmental disorder associated with physical and cognitive impairments, often attributed to mutations in the SCN1A gene. However, gene regulatory features that modulate SCN1A expression found in vivo...
Increased Neuroplasticity in Frontal Cortex to Reduce Compulsive Behavior: A Preclinical tDCS Study in Male Rats [0.03%]
通过临床tDCS实验研究增加雄性大鼠 frontal cortex 的神经可塑性以减少强迫行为
Manuela Olmedo-Córdoba,Angeles Prados-Pardo,Elena Martín-González et al.
Manuela Olmedo-Córdoba et al.
Compulsive behavior is a potential transdiagnostic symptom highly present in different neuropsychiatric disorders, including obsessive-compulsive disorder (OCD), anxiety, schizophrenia, and addiction. Transcranial direct current stimulation...
Grape Seed Proanthocyanidins Mitigate Acute High-Altitude Hypoxia-Induced Brain Injury by Inhibiting NLRP3 Inflammasome via Autophagy Pathway [0.03%]
葡萄籽原花青素通过自噬途径抑制NLRP3炎性小体缓解急性高海拔缺氧诱导的脑损伤
Danyi Huang,Chongyi Ai,Yingying Guo et al.
Danyi Huang et al.
Grape seed proanthocyanidins (GSPs) have been receiving extensive attention due to their outstanding brain protection role in various disease models. This study aimed to explore the therapeutic effects of GSPs against acute high-altitude hy...
Madecassoside Accelerates Nerve Regeneration by Promoting M2 Macrophage Polarization via TXNIP/NLRP3/GSDMD Pathway [0.03%]
马达加斯加苷通过TXNIP/NLRP3/GSDMD信号通路促进M2型巨噬细胞极化从而加速神经再生
Changqing Li,Xianyu Meng,Shengji Li et al.
Changqing Li et al.
The functional re-establishment and reinnervation of peripheral nerves following crush injuries represent the major clinical challenges for surgeons. Sustained existence of inflammatory microenvironment is detrimental for peripheral nerve r...
Wenyige Zhang,Haina Zheng,Yulian Pang et al.
Wenyige Zhang et al.
Glaucoma is a globally recognized leading cause of irreversible blindness, and its progression is closely associated with retinal ganglion cell (RGC) degeneration and mitochondrial dysfunction. Recently, there has been growing interest in t...