Single Electrically Induced Epileptic Afterdischarge Triggers Synaptic Weakening, AMPA Receptor Endocytosis, and Shrinkage of Dendritic Spines in the Hippocampus [0.03%]
单一电诱导癫痫发作后反应导致海马突触减弱，AMPA受体内陷以及树突棘缩小
Ana Paula Crestani,Leonardo Rakauskas Zacharias,Danilo Benette Marques et al.
Ana Paula Crestani et al.
Afterdischarge (AD) is an experimental model of electrically induced seizures. When induced in limbic structures, AD is known to induce acute behavioral alterations and flattening of local field potentials that persist for a few minutes. Ho...
Effects and Mechanisms of NMDAR-EphB2 on Synapses in Mice by Active Immunization with a GluN1 Peptide [0.03%]
GluN1免疫激活小鼠NMDAR-EphB2突触效应及机制研究
Kai Qian,Youshi Meng,Lin Zhang et al.
Kai Qian et al.
This study investigated the expression of N-methyl-D-aspartate receptor(NMDAR)-EphB2 and associated changes in hippocampal neuronal dendritic spines and synaptic ultrastructure in an anti-NMDAR encephalitis mouse model. Utilizing the GluN13...
Necl-4/CADM4 regulates GABAergic synaptic strength on GABAergic inhibitory neurons via ErbB4 activation and prevents neuronal impairments [0.03%]
Necl-4/CADM4通过ErbB4活化调节GABA能抑制神经元上的GABA能突触强度从而防止神经元损伤
Ryouhei Komaki,Hajime Shiotani,Toshihiko Kuriu et al.
Ryouhei Komaki et al.
Neural networks comprise excitatory and inhibitory neurons, linked through excitatory and inhibitory synapses. Synaptic excitation/inhibition balance is controlled for brain development and functions, and its dysregulations are implicated i...
Inhibition of the HIF-1α Signaling Pathway Promotes Oligodendrocyte Maturation in the In Vitro Model of Perinatal Asphyxia [0.03%]
缺氧缺血条件下HIF-1α信号通路抑制促进少突胶质细胞成熟
Justyna Janowska,Malgorzata Ziemka-Nalecz,Joanna Sypecka
Justyna Janowska
Preterm or complicated labor is often accompanied by the asphyxia of the newborn. Temporal limitation of oxygen and nutrient supply can be especially harmful to the developing brain and lead to hypoxic-ischemic encephalopathy. This injury i...
Deficiency of PLA2G6 Induces Ferroptosis in Dopaminergic Neurons and Contributes to Parkinson's Disease Pathogenesis via Disruption of PRDX6/FTH1/GPX4 Axis [0.03%]
PLA2G6缺乏通过破坏PRDX6/FTH1/GPX4轴诱发多巴胺能神经元铁死亡并参与帕金森病发病机制
Taole Li,Jiabin Liu,Xiurong Huang et al.
Taole Li et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder primarily characterized by the progressive loss of dopaminergic neurons. Mutations in the PLA2G6 gene, which encodes calcium-independent phospholipase A2 (iPLA2β), have b...
Memory-Associated Immediate Early Genes: Roles in Synaptic Function, Memory Processes, and Neurological Diseases [0.03%]
记忆相关即早基因在突触功能、记忆过程及神经精神疾病中的作用
Zafar U Khan,Marta Carretero-Rey,Cristina A Muñoz de León-López et al.
Zafar U Khan et al.
The expression of immediate early genes (IEGs) in the brain is rapidly upregulated during learning or in response to an event. This upregulation often correlates with neuronal activity in interconnected brain regions that form circuits asso...
Mitochondrial-Derived Peptides: Implication in the Therapy of Neurodegenerative Diseases [0.03%]
线粒体衍生肽在神经退行性疾病治疗中的意义
Rahul Thakur,Aman Chauhan,Hardika Moudgil et al.
Rahul Thakur et al.
Mitochondrial-derived peptides (MDPs), including humanin, MOTS-c, and small humanin-like peptides (SHLPs), have emerged as promising therapeutic candidates for neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease...
Galanin-Mediated Inflammatory Responses in Zebrafish Spinal Cord Regeneration [0.03%]
参与斑马鱼脊髓再生的galanin介导炎症反应
Shiho Okitsu-Sakurayama,Natalia Kasica,Małgorzata Potoczna et al.
Shiho Okitsu-Sakurayama et al.
Spinal cord injury (SCI) causes significant sensory and motor deficits and paralysis due to the limited regenerative capacity of the mammalian central nervous system (CNS). The inflammatory response triggered by the injury is critical for s...
TAT and RVG Co-modified MSC-derived Exosomes-mediated Delivery of microRNA-15b-5p Inhibitor Alleviate Cerebral Ischemia and Reperfusion-induced Neuronal Apoptosis by Promoting HTR2C-ERK Signaling [0.03%]
经RVG和TAT共修饰的MSC来源的外泌体递送microRNA-15b-5p抑制剂通过促进HTR2C-ERK信号缓解脑缺血再灌注诱导的神经元凋亡
Guoxing You,Xiaomin Chen,Xiaojun Ma et al.
Guoxing You et al.
Neuronal apoptosis significantly contributes to brain damage in cerebral ischemia and reperfusion (I/R) injury, posing a serious threat to human health and lacking effective treatment. MicroRNA-15b-5p (miR-15b-5p) was previously reported to...
Syringaldehyde Ameliorates Cognitive Dysfunction in APP/PS1 Mice by Stabilizing the NLRP3 Pathway [0.03%]
香草醛通过稳定NLRP3通路改善APP / PS1小鼠的认知障碍
Ruidan Chen,Hua Gao,Tianshu Zhu et al.
Ruidan Chen et al.
This study aimed to assess the therapeutic efficacy of syringaldehyde (SYD) in Alzheimer's disease (AD) and to investigate its potential underlying molecular mechanisms. The potential of SYD for AD treatment was first explored through a net...