Retraction Note to: Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice [0.03%]
撤回 notice: 芹菜素对衰老小鼠 β淀粉样蛋白诱导的认知/突触障碍、神经炎症和神经变性的神经营养作用
Ashfaq Ahmad,Tahir Ali,Hyun Young Park et al.
Ashfaq Ahmad et al.
DDX3X Aggravates Neuronal Pyroptosis and Inhibits Autophagy via NLRP3 Inflammasome After Experimental Subarachnoid Hemorrhage [0.03%]
DDX3X通过NLRP3炎症小体促进实验性蛛网膜下腔出血后的神经元焦亡并抑制自噬
Guangzhi Hao,Yu Huan,Yuwei Han et al.
Guangzhi Hao et al.
Neuronal cell death is considered the symbol of early brain injury after subarachnoid hemorrhage (SAH), but the mechanism was still unclear. DDX3X, a member of the DEAD-box helicase family, has a major effect on immune inflammation by media...
Brain-Derived Exosomes in Neurodevelopmental and Neuropsychiatric Disorders: Molecular Insights, Therapeutic Potential, and Translational Challenges [0.03%]
脑源性外泌体在神经发育和神经精神障碍中的作用：分子机制、治疗潜力及转化挑战
Masoud Nikanfar,Cigir Biray Avci,Asghar Khalilnezhad et al.
Masoud Nikanfar et al.
Neurodevelopmental disorders (NDDs), including autism spectrum disorders, attention-deficit hyperactivity disorders, schizophrenia, bipolar disorders, and other neurological disorders, present significant diagnostic and therapeutic challeng...
Single-Cell RNA-Seq Revealed the Immune Microenvironment Reprogramming by Dexmedetomidine Treatment in Ischemic Stroke [0.03%]
单细胞RNA测序揭示了右美托咪啶治疗缺血性脑卒中重塑免疫微环境
Wenyi Zhang,Xingyun Wang,Bing Zhang et al.
Wenyi Zhang et al.
Prior studies have indicated that the neuroprotective effects of dexmedetomidine (DEX) in cerebral ischemia, yet its mechanisms remain elusive. Using multi-omics approaches (RNA-seq, metabolomics, and single-cell RNA-seq), we discovered tha...
Formulation and Evaluation of Astaxanthin-Loaded Invasomes as Therapeutic Approaches for Alzheimer's Disease Induced in Rats: Role of SIRT-1/BDNF/miRNA-134/GSK-3β Signaling [0.03%]
虾青素负载侵入体在阿尔茨海默病治疗中的应用及评价：对SIRT-1/BDNF/miRNA-134/GSK-3β信号通路的作用研究
Mohamed A Kandeil,Eman T Mohammed,Marwa A Ibrahim et al.
Mohamed A Kandeil et al.
Alzheimer's disease (AD) is a progressive age-dependent neurodegenerative disorder associated with oxidative brain damage, disrupted neuronal transmission, memory loss, and behavioral changes, with aluminum being a key environmental risk fa...
Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders [0.03%]
端粒生物学、端粒磨损与年龄相关性疾病：唐氏综合征及其他端粒关联疾病带来的启示
Enikő Kutasi,Adina Chis,Mihaela Adela Vintan et al.
Enikő Kutasi et al.
Telomeres play a crucial role in safeguarding DNA integrity. With each cell division, these protective structures undergo shortening, limiting the number of divisions to prevent improper genetic material distribution in aging cells. Senesce...
Resveratrol's Multifaceted Potential in Alzheimer's Disease: Insights from Preclinical and Clinical Evidence [0.03%]
白藜芦醇在阿尔茨海默病中的多重潜力：来自前期和临床证据的见解
Shivani Patel,Alison Thornton,Mayur S Parmar
Shivani Patel
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles (NFTs), and neuroinflammation, leading to progressive cognitive decline. Research has increasingly emp...
Obesity and Cognitive Function: Leptin Role Through Blood-Brain Barrier and Hippocampus [0.03%]
肥胖与认知功能：通过血脑屏障和海马的瘦素作用
Ebtesam Abdullah Al-Suhaimi,Abdullah A AlRubaish,Hanan A Aldossary et al.
Ebtesam Abdullah Al-Suhaimi et al.
The signal transduction and communication between adipose tissue-secreted adipokines and the central nervous system (CNS) are increasingly recognized for their role in metabolic and neurological regulation. This crosstalk contributes to the...
Insights into Caspase-6 Mutations and Neuropathology in Huntington's Disease and Psychiatric Disorders: A Structural Genomics and Drug Repurposing Approach [0.03%]
Caspase-6突变与亨廷顿舞蹈病及精神疾病神经病理的关联：结构基因组学和老药新用研究方法启示
Mohammed Ageeli Hakami,Ahad Amer Alsaiari,Ali Hazazi et al.
Mohammed Ageeli Hakami et al.
Huntington's disease (HD) is an inherited neurodegenerative condition that typically appears later in life, marked by progressive motor impairments, cognitive deterioration, and a range of psychiatric disturbances. Crucial to HD pathogenesi...
Semaglutide Mitigates Ischemic Brain Injury by Inhibiting Ferroptosis via Modulation of FoXO1 and DRP1 Pathways [0.03%]
索马鲁肽通过调节FoXO1和DRP1途径抑制铁死亡从而减轻缺血性脑损伤
Weihua Wang,Meng Pang,Yifeng Zhang et al.
Weihua Wang et al.
Multiple pathogenic processes contribute to cerebral ischemia-reperfusion injury (CIRI); however, their relative importance and sequence remain unclear, warranting further investigation. Although our previous studies showed that inhibiting ...