Pinocembrin Alleviates Postoperative Cognitive Dysfunction in Aged Mice by Modulating miR-384-5p/FZD1 Axis to Activate the Wnt/β-Catenin Pathway [0.03%]
姜黄素类似物 pinocembrin通过调控 miR-384-5p/FZD1轴来激活 Wnt/β-catenin信号通路从而缓解老年小鼠术后认知功能障碍
Jie Li,Xue-Li Peng,Xin-Yu Cheng et al.
Jie Li et al.
Postoperative cognitive dysfunction (POCD) is a clinically recognized complication of surgery that compromises long-term neurological outcomes, though its mechanistic basis remains poorly defined. The flavonoid Pinocembrin (5,7-dihydroxyfla...
Ecdysterone and High-Intensity Interval Training Mitigate Alzheimer's Pathology in Rats: Impacts on Depression, Synaptic Plasticity, and Neuroinflammation [0.03%]
虫漆酚和高强度间歇训练可缓解大鼠阿尔茨海默病病理：对抑郁、突触可塑性和神经炎症的影响
Parsa Gholipour,Alireza Komaki,Hesam Parsa et al.
Parsa Gholipour et al.
The study focuses on the role of neuroinflammation and impaired synaptic plasticity in the progression of Alzheimer's disease caused by amyloid-beta accumulation. It examines the potential therapeutic effects of Ecdysterone, known for its a...
17β-Trenbolone Increases the Release of Lipocalin 2 via the Brain-Liver Axis and Causes Alzheimer's Disease-Like Symptoms in CSDS-Induced Mice [0.03%]
17β-特罗伯龙通过脑-肝轴增加脂联素2的释放并导致CSDS诱导的小鼠产生类似阿尔茨海默病的症状
Xiang Zuo,Xiaochen Kuang,Yudi Zhao et al.
Xiang Zuo et al.
Aims: This study aimed to investigate the neurological and behavioural effects of exposure to the environmental endocrine disruptor 17β-trenbolone (17-TB) exposure in chronic social defeat stress (CSDS)-induced mice and ...
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation [0.03%]
微塑料和纳米塑料的神经毒性负担解析：从多模态实验证据到治疗创新
Smita Kumari,M Yasmin Begum,Chingakham Chinglenthoiba et al.
Smita Kumari et al.
The widespread production of plastic in all daily appliances and its poor non-biodegradable characteristics along with toxic plasticizers pose significant risks to human health, leading to several life-threatening conditions, including neur...
Trichloroethylene Exposure and Parkinson's Disease: Environmental Risk, Metabolic Pathways, and Mechanistic Insights [0.03%]
三氯乙烯暴露与帕金森病：环境风险、代谢途径和机制启示
Ruifang Liu,Furong Zhang,Jianwei Lou et al.
Ruifang Liu et al.
Trichloroethylene (TCE) is a widely used industrial solvent noted for its environmental persistence and unique metabolic profile. In recent years, a growing body of epidemiological research and experimental models has implicated TCE exposur...
Mechanisms of Senegenin in Regulating Oxidative Stress and Mitochondria Damage for Neuroprotection in Insomnia: Evidence from In Vivo and In Vitro Models [0.03%]
失眠病理性氧化应激及线粒体损伤的机制及其药物干预：自体及细胞水平模型实证研究
Honglin Jia,Zhengting Liang,Deqi Yan et al.
Honglin Jia et al.
Insomnia is a common sleep disorder worldwide, and oxidative stress and mitochondrial damage are closely related to insomnia. This study aimed to investigate the mechanism by which senegenin exerts neuroprotective effects in regulating oxid...
PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation [0.03%]
正电子发射断层显像揭秘精神疾病中的神经炎症机制：从小胶质细胞活化到治疗创新
Yu-Dan Liu,Yi-Heng Chang,Xue-Ting Xie et al.
Yu-Dan Liu et al.
Recent advancements in neuroinflammation research have significantly enhanced our understanding of its pivotal role in the pathogenesis and pathophysiology of psychiatric disorders. Positron emission tomography (PET) imaging, leveraging its...
Mbnl1 Protects Against Cerebral Ischemia-Reperfusion Injury by Modulating Microglia/Macrophage Polarization via NF-κB Pathway [0.03%]
MBNL1通过NF-κB途径调节小胶质细胞/巨噬细胞极化以对抗脑缺血再灌注损伤
Wenting Xu,Mengjia Zhou,Linlin Li et al.
Wenting Xu et al.
Activated and polarized microglia regulate neuroinflammatory responses and programmed cell death processes in ischemic stroke. Although the inactivation of muscleblind-like 1 (Mbnl1) is known to cause structural defects in the brain, its ro...
The Efficacy of Intrathecal Platelet-Rich Plasma Administration in Alleviation of Chronic Neuropathic Pain in Rat Model [0.03%]
富血小板血浆脑池内注射对坐骨神经慢性压迫大鼠模型疼痛的缓解作用及机制研究
Jaisan Islam,Preeti Kumari Chaudhary,Sanggu Kim et al.
Jaisan Islam et al.
Chronic neuropathic pain (CNP), marked by various stinging sensations, frequently arises from lumbosacral disorders, where astrocytes in the spinal dorsal horn (SDH) significantly contribute to its persistence. Platelet-rich plasma (PRP) tr...
Pathway Analysis and Genetic Markers in Parkinson's Disease: Insights into Subtype-Specific Mechanisms [0.03%]
帕金森病的通路分析和遗传标志物：探究亚型特异性机制的洞察
Sara Taremi Horoufi,Davood Zaeifi
Sara Taremi Horoufi
Parkinson's disease (PD) is a complex disease influenced by both genetic and environmental factors. Despite advances in understanding PD genetics, subtype-specific mechanisms remain poorly characterized. This study aims to identify distinct...