Exploring the Link Between IL-6 rs1800795 G > C SNP and the Severity of Epstein-Barr Virus-Associated Multiple Sclerosis: Potential Impact on Cognitive Impairment [0.03%]
白细胞介素6基因多态性与EB病毒相关多发性硬化症严重程度及认知功能损伤的关系研究
Tokka M Hassan,Azza M El Amir,Nahla Elsayed Nagy et al.
Tokka M Hassan et al.
Multiple Sclerosis (MS) is a chronic immune-mediated neurological disorder frequently accompanied by cognitive impairment, which affects up to 60% of patients and is associated with faster disease progression and greater disability. Interle...
DTX1 Modulates Microglial M1 Polarization and Exacerbates Neuroinflammation in Traumatic Brain Injury Model Rats through NF-κB/IRF5 [0.03%]
DTX1通过NF-κB/IRF5调节小胶质细胞M1极化并加重脑创伤模型大鼠的神经炎症反应
Yonghui Zhang,Zongxing Zou,Rongwei Li et al.
Yonghui Zhang et al.
Microglial polarization is crucial in the pathogenesis of traumatic brain injury (TBI), yet the underlying regulatory mechanisms remain incompletely understood. In this study, we investigated the role of Deltex E3 ubiquitin ligase 1 (DTX1) ...
Effect of High-Rate Repetitive Transcranial Magnetic Stimulation on Phonophobia and Brainstem Auditory Evoked Potential in Migraine [0.03%]
高强度重复经颅磁刺激对偏头痛耳鸣及脑干听觉诱发电位的影响
Jayantee Kalita,Robin Bansal,Roopali Mahajan et al.
Jayantee Kalita et al.
Phonophobia is a cardinal symptom in migraine, and migraineur may have impaired habituation of brainstem auditory evoked potential (BAEP). High-rate repetitive transcranial magnetic stimulation (rTMS) has been found effective in migraine, b...
Gipc3 Mutation Might Cause Sensorineural Hearing Loss by Inhibiting Mitophagy in Inner Ear Hair Cells [0.03%]
Gipc3基因突变通过抑制耳蜗毛细胞线粒体自噬导致感音神经性聋
Xinxin Li,Jing Wang,Lin Shi et al.
Xinxin Li et al.
Sensorineural hearing loss (SNHL) has a high degree of genetic heterogeneity, with numerous mutated genes that contribute to deafness. GIPC3 gene is one of the mutated genes that can cause congenital hearing loss, which has been identified ...
Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Seizure Frequency and Brain Metabolomics of Rats with Pilocarpine-Induced Seizures [0.03%]
慢性经颅近红外激光光生物调节对匹罗卡品诱导的癫痫大鼠发作频率及脑代谢组学的影响
Fabrizio Dos Santos Cardoso,Ricardo Mario Arida,Eduardo Alves da Silva et al.
Fabrizio Dos Santos Cardoso et al.
Epilepsy is a chronic brain disorder characterized by abnormal and highly synchronous activity of neuronal cells. This condition is often associated with neuronal hyperexcitability and metabolic imbalances in regions such as the neocortex a...
Activation of the C3 Complement Pathway in the Hippocampus Produces Anxiodepressive Effects in a Mouse Model of Inflammation Pain [0.03%]
小鼠炎症痛模型中补体C3活化产生抑郁和焦虑样行为的作用及机制研究
Aomei Zhang,Xinxin Zhang,Xiaohan Tang et al.
Aomei Zhang et al.
The comorbidity of anxiety and depression frequently occurs in patients with inflammatory pain, which requires further investigation. Previous evidence supports a close link between Complement Component 3 (C3) and affective disorders; howev...
Overexpression of mGlu7B in Mice: Implications for Neurodevelopmental Disorders [0.03%]
小鼠mGlu7B过表达：对神经发育障碍的启示
Geanne A Freitas,Kelly Weiss,Vaishnavi Bavadekar et al.
Geanne A Freitas et al.
Metabotropic glutamate receptor 7 (mGlu7) is a G protein-coupled receptor (GPCR) involved in neurotransmitter release throughout the central nervous system (CNS). Low levels of the receptor are correlated with intellectual disability, autis...
The Crosstalk Between Sepsis-Associated Encephalopathy and Alzheimer's Disease: Identifying Potential Biomarkers and Therapeutic Targets for Cognition [0.03%]
脓毒症相关性脑病与阿尔茨海默病的相互作用：识别认知障碍的潜在生物标志物和治疗靶点
Zhitong Wang,Zhiling Zhang,Jing Shi et al.
Zhitong Wang et al.
Patients with sepsis are at a heightened risk of long-term cognitive impairment, including neurodegenerative diseases; however, the underlying pathophysiological mechanisms remain incompletely understood. This study examines key genes assoc...
EP300 Regulates CD8br AC (TBNK Panel) to Facilitate Insomnia [0.03%]
EP300通过调控CD8+AC（TBNK panels）促进失眠症发生发展的作用及机制研究
Xin Men,Qian Wang
Xin Men
Insomnia is a prevalent clinical condition that is caused by the interaction of environmental, inflammatory, immune system, physiological, and psychological factors. Nevertheless, the significance of lactylation-related gene in the pathogen...
Exosome-Mediated Delivery of Amyloid Beta Modulators: A Potential Therapeutic Strategy for Alzheimer's Disease [0.03%]
用于阿尔茨海默病治疗的外泌体介导的β淀粉样蛋白调节剂递送策略
Tehreem Mushtaq,Huma Hameed,Ana Cláudia Paiva-Santos et al.
Tehreem Mushtaq et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and tau protein abnormalities, disrupting synaptic function and causing progressive cognitive decline. However, significa...