Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective [0.03%]
来自印度东部的卒中幸存者不同时间发病的临床意义：一种昼夜节律视角
Dipanwita Sadhukhan,Arunima Roy,Tapas Kumar Banerjee et al.
Dipanwita Sadhukhan et al.
The circadian variation in stroke occurrence is a well-documented phenomenon. However, the circadian effect on stroke outcome, particularly on post-stroke cognition, has not yet been fully elucidated. We aim to evaluate the influence of diu...
Continuous Theta Burst Stimulation Inhibits Oxidative Stress-Induced Inflammation and Autophagy in Hippocampal Neurons by Activating Glutathione Synthesis Pathway, Improving Cognitive Impairment in Sleep-Deprived Mice [0.03%]
连续theta burst刺激通过激活谷胱甘肽合成通路抑制氧化应激诱导的炎症和自噬改善睡眠剥夺小鼠海马神经元的认知障碍
Yi Zhang,Cheng Zhang,Qing Dai et al.
Yi Zhang et al.
Sleep deprivation (SD) has been reported to have a negative impact on cognitive function. Continuous theta burst stimulation (cTBS) shows certain effects in improving sleep and neurological diseases, and its molecular or cellular role in SD...
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments [0.03%]
结合单细胞测序、机器学习算法及体外实验鉴定缺血性卒中中的半胱氨酸蛋白酶依赖的凋亡相关基因
Songyun Zhao,Hao Zhuang,Wei Ji et al.
Songyun Zhao et al.
Background: Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently, a novel form of cell death known as disulfidptosis has garnered significant attention ...
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For? [0.03%]
脑部疾病和中风中的血液-脑脊液屏障功能障碍：为什么？如何？有何意义？
Khiany Mathias,Richard Simon Machado,Taise Cardoso et al.
Khiany Mathias et al.
Ischemic stroke (IS) results in the interruption of blood flow to the brain, which can cause significant damage. The pathophysiological mechanisms of IS include ionic imbalances, oxidative stress, neuroinflammation, and impairment of brain ...
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury [0.03%]
CRMP2去磷酸化抑制可抑制视神经损伤后的视网膜小胶质细胞活化及促进视神经再生
Yuebing Wang,Sayaka Harada,Yoshio Goshima et al.
Yuebing Wang et al.
As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmission. Injuries to the optic nerve can occur for various reasons, including trauma, glaucoma, and neurodegenerative disea...
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes [0.03%]
脆性X综合症皮层星形胶质细胞中失调的嘌呤能信号转导
Kathryn E Reynolds,Matthew Napier,Fan Fei et al.
Kathryn E Reynolds et al.
The symptoms of fragile X syndrome (FXS), caused by a single gene mutation to Fmr1, have been increasingly linked to disordered astrocyte signalling within the cerebral cortex. We have recently demonstrated that the purinergic signalling pa...
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions [0.03%]
缺氧葡萄糖剥夺条件下抑制VGLUT1减轻HT22细胞损伤的作用及机制研究
B Pomierny,W Krzyżanowska,A Skórkowska et al.
B Pomierny et al.
Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity, and memory formation. However, its dysregulation leads to excitotoxicity, implicated in neurodegenerative diseases an...
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury [0.03%]
骨髓间充质干细胞源外泌体GDNF在慢性约束损伤大鼠模型中的作用及其机制研究
Xuelei Zhang,Huan Liu,Xiaolei Xiu et al.
Xuelei Zhang et al.
Both of exosomes derived from mesenchymal stem cells (MSCs) and glial cell line-derived neurotrophic factor (GDNF) show potential for the treatment of neuropathic pain. Here, the analgesic effects of exosomes derived from bone marrow MSCs (...
Activation of GPR30 Ameliorates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway [0.03%]
激活GPR30通过Nrf2/GPX4信号通路抑制铁死亡改善脑缺血再灌注损伤
Yong-Qiang Zhang,Ting Sun,Zhen Zhao et al.
Yong-Qiang Zhang et al.
The newly identified estrogen receptor, G protein-coupled receptor 30 (GPR30), is prevalent in the brain and has been shown to provide significant neuroprotection. Recent studies have linked ferroptosis, a newly characterized form of progra...
Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach [0.03%]
基于计算和体内实验方法评估肠道微生物在帕金森病中的神经保护作用
Kanika Bhardwaj,Neelu Kanwar Rajawat,Nupur Mathur et al.
Kanika Bhardwaj et al.
Parkinson's disease is a progressive neurodegenerative disorder marked by the death of dopaminergic neurons in the substantia nigra region of the brain. Aggregation of alpha-synuclein (α-synuclein) is a contributing factor to Parkinson's d...