Morpholino Knockdown in Zebrafish: A Tool to Investigate the Functional Impact of Variants of Unknown Significance in Mitochondrial Diseases [0.03%]
斑马鱼反义吗啉嵌合体敲低技术在线粒体疾病基因变异功能研究中的应用
Mateus Laranjeira,Jorge M A Oliveira,Filippo M Santorelli et al.
Mateus Laranjeira et al.
Mitochondrial diseases (MDs) are heterogeneous multisystemic disorders often caused by genetic defects in either nuclear or mitochondrial DNA. Although next-generation sequencing technologies have dramatically expanded the number of variant...
Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway [0.03%]
通过NLRP3/Caspase-1/GSDMD通路冰片查素II缓解阿尔茨海默病的进展
Shuyue Li,Ya Gao,Yidan Zhang et al.
Shuyue Li et al.
Alzheimer's disease (AD), an irreversible, degenerative disorder, affects the central nervous system. However, its accurate pathology remains unclear, and studies on treatment modalities are ongoing. Picroside II (PII) is an active compound...
Sex-Dependent Regional Vulnerability and Recovery Mechanisms in a Mouse Model of Transient Global Cerebral Ischemia [0.03%]
全球脑缺血小鼠模型中与性别相关的区域易损性和恢复机制
Debiprasad Sinha,Roli Kushwaha,Shashikant Patel et al.
Debiprasad Sinha et al.
This study investigates the influence of sex on region-specific neural vulnerability following global cerebral ischemia using a Bilateral Common Carotid Artery Occlusion (BCCAo) mouse model that mimics severe ischemic brain stroke condition...
Fisetin Augments OEC Neuroprotection Through Modulating Neurotrophin/Cytokine Signaling and Activating PI3K/Akt/CREB Pathway in an In Vitro Neurodegenerative Injury [0.03%]
山柰酚通过调节神经营养因子/细胞因子信号传导并激活PI3K/Akt/CREB途径增强OEC神经保护作用的体外神经退行性损伤研究
Yizhen Jiang,Jianbin Guo,Yan Yang et al.
Yizhen Jiang et al.
The persistence of deleterious substances at lesion sites severely impedes neuronal survival and axonal regeneration following central nervous system (CNS) injury or in neurodegenerative disorders. Therefore, clearing these harmful componen...
The Role of Gut Microbiota in Modulating Immune Signaling Pathways in Autoimmune Diseases [0.03%]
肠道菌群在自身免疫性疾病中调节免疫信号通路的作用
Nada Khairi Younis,Karar H Alfarttoosi,Gaurav Sanghvi et al.
Nada Khairi Younis et al.
The composition of intestinal microbial communities plays a crucial role in maintaining immune homeostasis, influencing both innate and adaptive immune responses. Growing evidence indicates that bidirectional communication between gut bacte...
Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice [0.03%]
高血压诱导小鼠海马和皮质乙酰胆碱受体mRNA表达的改变及认知功能损伤
Jingfeng Liu,Jianting Hou,Jianlin Wu et al.
Jingfeng Liu et al.
Hypertension is a significant risk factor for cognitive decline and dementia, yet the underlying mechanisms linking hypertension to cognitive impairments remain poorly understood. Central acetylcholine (ACh) receptors play a crucial role in...
Engineering the Microbiome: a Novel Approach to Managing Autoimmune Diseases [0.03%]
工程改造微生物组：一种管理自身免疫性疾病的新方法
Thabit Moath Omar,Karar H Alfarttoosi,Gaurav Sanghvi et al.
Thabit Moath Omar et al.
Autoimmune diseases occur when the immune system mistakenly attacks the body's own tissues, affecting millions of people and often requiring long-term treatment. Current therapies, such as immunosuppressants and biologics, help manage sympt...
When Heroes Fall: Reduced Expression of Heat-Resistant Obscure Proteins in Ischemic Stroke [0.03%]
英雄陨落：缺血性脑卒中患者热稳定隐蛋白表达降低
Anna Dorofeeva,Ksenia Kobzeva,Vladislav Soldatov et al.
Anna Dorofeeva et al.
The recently discovered family of heat-resistant obscure (Hero) proteins represents a novel class with chaperone-like activity and unique protective properties. These proteins may contribute to cellular survival in ischemic stroke (IS) cond...
Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice [0.03%]
3xTg-AD小鼠而非Tg-Swidipole小鼠出现脾肿大、淀粉样变性和中性粒细胞浸润现象
Gonzalo Acero,Adrian Rodriguez-Lopez,Georgina Díaz et al.
Gonzalo Acero et al.
It is now widely accepted that the development of neurodegenerative diseases depends on and affects many pathological processes, both in the brain and the periphery. Inflammatory, cardiovascular, metabolic, cerebrovascular, autoimmune, and ...
Neuroprotective Activity of Eriodictyol Against Streptozotocin-Induced Diabetic Peripheral Neuropathy in Wistar Rats by Targeting Wnt/β-Catenin Pathway [0.03%]
姜黄素茋通过靶向Wnt/β-连环蛋白信号途径对抗链佐星诱导的糖尿病周围神经病变的神经保护作用
Renu Malik,Balvinder Singh,Ajay Singh Kushwah et al.
Renu Malik et al.
Long-term hyperglycemia and insulin dysfunction deteriorate peripheral nerve functions, leading to sensory loss, spontaneous pain, and hypersensitivity (i.e., allodynia and hyperalgesia). Evidence indicates glucose-induced upregulation of t...