Celiac Disease and the Nervous System: A Comprehensive Overview of Neurological Manifestations and Underlying Mechanisms [0.03%]
乳糜泻与神经系统：神经表现及潜在机制的全面综述
Arash Yousefzadeh Eshkoori,Mohadeseh Mahmoudi Ghehsareh,Nastaran Asri et al.
Arash Yousefzadeh Eshkoori et al.
Celiac disease (CD) is a chronic immune-mediated enteropathy triggered by gluten ingestion in genetically susceptible individuals. While traditionally associated with gastrointestinal (GI) symptoms, CD is increasingly recognized as a system...
Research Progress on Regulating Neuroinflammation After Spinal Cord Injury by Targeting the cGAS-STING Pathway [0.03%]
靶向cGAS-STING通路调节脊髓损伤后神经炎症的研究进展
Nanjian Xu,Weihu Ma,Weixin Dong et al.
Nanjian Xu et al.
Neuroinflammation following secondary injury in spinal cord injury (SCI) constitutes a major obstacle to functional recovery. Endogenous danger signals, particularly mitochondrial DNA (mtDNA) released post-injury, can activate the cGAS-STIN...
LncRNA DLX6-AS1 Regulates the Pathological Process Related to Alzheimer's Disease via miR-204-5p [0.03%]
长链非编码RNA DLX6-AS1通过miR-204-5p调节与阿尔茨海默病相关的病理过程
Minggang Jiang,Yang Lin,Liping Wang et al.
Minggang Jiang et al.
Alzheimer's disease (AD) is a neurodegenerative disorder causing progressive neuronal damage. Incidence rises with age, and early diagnosis is difficult. This study examined DLX6-AS1 clinical relevance and regulatory mechanism in AD, and it...
Chemogenetic Activation of Neurons Promotes Axonal Regeneration and Ameliorates Neurological Deficits in Mice with Intracerebral Hemorrhage by Modulating Mitochondrial Function [0.03%]
通过调节线粒体功能促进神经元轴突再生和改善脑内出血小鼠的神经系统缺陷的化学遗传学方法激活神经元
Jinpeng Wang,Li Zhou,Chunxiao Pang et al.
Jinpeng Wang et al.
Intracerebral hemorrhage (ICH) is a devastating neurological condition characterized by high morbidity and mortality, with limited treatment options for promoting neurological recovery. Enhancing cortical excitability has emerged as a poten...
Sleep Duration and Epilepsy Risk: Mendelian Randomization and Functional Validation of CACNA1A rs2228130-Related Inhibitory Synaptic Dysfunction [0.03%]
睡眠时长与癫痫发病风险的关系：CACNA1A基因rs2228130位点多效性相关的抑制型突触障碍的孟德尔随机化及功能验证
Xun Li,Yuying Hou,Yanping Ren et al.
Xun Li et al.
Objectives To evaluate the causal association between sleep traits and epilepsy risk using Mendelian randomization, and to investigate the mechanism of a prioritized epilepsy-risk variant through gene-level enrichment analysis and functiona...
STAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease [0.03%]
STAT6通过靶向自噬途径调节脑小血管病所致认知障碍的微胶质细胞衰老
Xiaolu Liu,Qing Liu,Jingwen Yang et al.
Xiaolu Liu et al.
Cerebral small-vessel disease (CSVD) represents a major etiology of vascular cognitive impairment (VCI), driven by pathological processes such as cellular senescence and neuroinflammation. Among these, microglia-the brain's specialized immu...
Near‑Infrared Photobiomodulation in White‑Matter Disease: From Microglial States to Measurable Endpoints [0.03%]
近红外光生物调节在白质疾病中的应用：从微胶质细胞状态到可测量的终点指标
Jiahao Zhang,Quanguang Zhang,J Dedrick Jordan et al.
Jiahao Zhang et al.
White-matter (WM) injury contributes to disability across multiple sclerosis, traumatic brain injury, Alzheimer's disease and related dementias, and small-vessel disease. We use microglial state programs as an organizing axis for WM injury-...
64Cu Hypoxia Imaging Radiotracer Targeting the Human Copper Transporter [0.03%]
64Cu低氧成像放射示踪剂靶向人类铜转运蛋白
Shelly Meron,Yulia Shenberger,Ravit Madar et al.
Shelly Meron et al.
The detection and characterization of hypoxia through functional imaging represents a critical frontier in oncology, cardiology, and neurology. Despite extensive efforts, the clinical translation of a robust hypoxia imaging biomarker remain...
Curculigoside Alleviates CSDS-induced Depressive-like Behavior by Modulating Pyramidal Neuron Excitability and Synaptic Transmission [0.03%]
.curculigoside通过调节锥体神经元兴奋性和突触传递来缓解慢性束缚社交挫败应激引起的类抑郁行为。
Yuhong Jing,Tianshu Zhang,Zihao Wei et al.
Yuhong Jing et al.
Curculigoside (CUR), a flavonoid derived from traditional Chinese medicine, has shown potential in alleviating depressive symptoms. However, the mechanisms underlying its antidepressant effects remain unclear. The aim of this study was to i...
Association of Cathepsin Proteins with Alzheimer's Disease Risk: An Integrated Observational and Genetic Analysis [0.03%]
蛋白酶与阿尔茨海默病风险的关系：一项综合观察和遗传学分析
Qianlong Zhang,Qingyang Li,Zisheng Ai et al.
Qianlong Zhang et al.
Alzheimer's disease (AD) involves complex lysosomal proteolytic dysfunction, but the specific roles of cathepsin family proteins remain unclear. This study aimed to systematically evaluate the association of cathepsins with AD risk and to e...
Observational Study
Neuromolecular medicine. 2026 Jun 18;28(1):38. DOI:10.1007/s12017-026-08933-w 2026