Targeting Microglial Activation to Modulate Neuroinflammation in Alzheimer's Disease [0.03%]
靶向小胶质细胞活化以调节阿尔茨海默病的神经炎症
Vinay Patil,Amit Sharma,Bhavin Parekh et al.
Vinay Patil et al.
Alzheimer's disease is a multifaceted neurodegenerative condition marked by the build-up of amyloid plaques and neurofibrillary tangles that lead to progressive cognitive impairment. Neuroinflammation, especially the activation of microglia...
Comparative Hippocampal Transcriptomics Reveals Model-Specific Pathways and Convergent Inflammation in Sepsis-Associated Encephalopathy [0.03%]
比较性海马转录组学揭示了脓毒症相关脑病的模型特异性途径和汇聚炎症反应
Xueling Zhang,Mengshi Yang,Yaxuan Zhang et al.
Xueling Zhang et al.
Sepsis-associated encephalopathy (SAE) is a serious sepsis complication with high mortality. Animal models, including cecal ligation and puncture (CLP), lipopolysaccharide (LPS) injection, and peritoneal contamination and infection (PCI), a...
Comparative Study
Neuromolecular medicine. 2025 Nov 27;27(1):75. DOI:10.1007/s12017-025-08896-4 2025
Longikaurin A - Mediated Regulation of ROS/JNK Signaling Counteracts Epithelial-Mesenchymal Transition in Glioblastoma [0.03%]
长苞山龙眼科喀尔文素A介导的ROS/JNK信号调节对抗胶质母细胞瘤上皮间充质转化
Hua Chen,Yangming Mao,Xiang Chen et al.
Hua Chen et al.
Glioblastoma (GBM) is a highly aggressive brain tumor characterized by rapid proliferation, therapy resistance, and extensive invasion, largely driven by epithelial-mesenchymal transition (EMT). Longikaurin A (LK-A), a natural kaurane diter...
Glutamic Acid at Position 168 Is a Constitutive Activator of Tank Binding Kinase 1 Catalytic Function [0.03%]
168位谷氨酸是TBK1催化功能的组成激活剂
Noopur Bhore,Anubhuti Sarkar,Zhi Yao et al.
Noopur Bhore et al.
TANK binding kinase 1 (TBK1) is serine/threonine protein kinase member of the inhibitor of nuclear factor-kB kinase family, with links to the etiology of familial as well as idiopathic Amyotrophic Lateral Sclerosis. It contributes to severa...
HDAC3 Epigenetic Suppression by Electroacupuncture Restores AMPA Receptor Function and Synaptic Plasticity in Alzheimer's Disease Models [0.03%]
电针通过表观遗传抑制HDAC3恢复阿尔茨海默病模型中的AMPA受体功能和突触可塑性
Hongzhu Li,Bing Deng,Mucan Lin et al.
Hongzhu Li et al.
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by continuous cognitive deterioration, primarily resulting from the accumulation of amyloid-β (Aβ) plaques and tau-induced neurofibrillary tangles (NFTs). Recent...
Aurintricarboxylic Acid Attenuates Tramadol Withdrawal Syndrome Via TWEAK/FN14 Inhibition and CREB Modulation in Mice Model [0.03%]
aurintricarboxylic酸通过抑制Tweak/fn14和调节c reb来缓解小鼠模型中的曲马多戒断综合征
Rajalaxmi,Shahid Nazir Wani,Amarjot Kaur Grewal et al.
Rajalaxmi et al.
Tramadol withdrawal presents a significant clinical challenge, characterized by neurobehavioral impairments linked to neuroinflammation, oxidative stress and neurotransmitter dysregulation. The TNF-like weak inducer of apoptosis (TWEAK)/fib...
Suppression of Glial Activation in Tau Transgenic Mice Through Inhibition of CRMP2 Phosphorylation: a Morphometric Analysis [0.03%]
通过抑制CRMP2磷酸化在Tau转基因小鼠中抑制星形胶质细胞活化的形态学分析
Wanying Li,Toshiki Kubota,Valeria Ayala Guevara et al.
Wanying Li et al.
Tauopathies, including Alzheimer's disease (AD), are neurodegenerative diseases characterized by abnormal tau aggregation in neurons and glial cells. Various tauopathy mouse models have been developed, including PS19, a tau-overexpressing t...
Morpholino Knockdown in Zebrafish: A Tool to Investigate the Functional Impact of Variants of Unknown Significance in Mitochondrial Diseases [0.03%]
斑马鱼反义吗啉嵌合体敲低技术在线粒体疾病基因变异功能研究中的应用
Mateus Laranjeira,Jorge M A Oliveira,Filippo M Santorelli et al.
Mateus Laranjeira et al.
Mitochondrial diseases (MDs) are heterogeneous multisystemic disorders often caused by genetic defects in either nuclear or mitochondrial DNA. Although next-generation sequencing technologies have dramatically expanded the number of variant...
Picroside II Alleviates the Progression of Alzheimer's Disease via the NLRP3/Caspase-1/GSDMD Pathway [0.03%]
通过NLRP3/Caspase-1/GSDMD通路冰片查素II缓解阿尔茨海默病的进展
Shuyue Li,Ya Gao,Yidan Zhang et al.
Shuyue Li et al.
Alzheimer's disease (AD), an irreversible, degenerative disorder, affects the central nervous system. However, its accurate pathology remains unclear, and studies on treatment modalities are ongoing. Picroside II (PII) is an active compound...
Sex-Dependent Regional Vulnerability and Recovery Mechanisms in a Mouse Model of Transient Global Cerebral Ischemia [0.03%]
全球脑缺血小鼠模型中与性别相关的区域易损性和恢复机制
Debiprasad Sinha,Roli Kushwaha,Shashikant Patel et al.
Debiprasad Sinha et al.
This study investigates the influence of sex on region-specific neural vulnerability following global cerebral ischemia using a Bilateral Common Carotid Artery Occlusion (BCCAo) mouse model that mimics severe ischemic brain stroke condition...