Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice [0.03%]
与海湾战争综合症有关的铝佐剂可诱导小鼠运动神经元死亡
Michael S Petrik,Margaret C Wong,Rena C Tabata et al.
Michael S Petrik et al.
Gulf War illness (GWI) affects a significant percentage of veterans of the 1991 conflict, but its origin remains unknown. Associated with some cases of GWI are increased incidences of amyotrophic lateral sclerosis and other neurological dis...
Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models [0.03%]
色胺通过亮肽酰转移酶介导诱导神经原纤维缠结的神经退行性疾病：人类细胞及小鼠模型研究
Elena L Paley,Galina Denisova,Olga Sokolova et al.
Elena L Paley et al.
The neuropathological hallmarks of Alzheimer's disease (AD) and other taupathies include neurofibrillary tangles and plaques. Despite the fact that only 2-10% of AD cases are associated with genetic mutations, no nontransgenic or metabolic ...
Lack of minocycline efficiency in genetic models of Huntington's disease [0.03%]
环孢素在亨廷顿舞蹈病基因模型中无效性研究
Stéphane Mievis,Marc Levivier,David Communi et al.
Stéphane Mievis et al.
According to the recent controversy regarding the effects of minocycline in the R6/2 transgenic model of Huntington's disease (HD), this tetracycline has been re-evaluated in another model, the N171-82Q strain. Ten miligrams per kilogram mi...
Defects of immune regulation in the presenilin-1 mutant knockin mouse [0.03%]
应用于条件性敲入突变体小鼠的免疫调节缺陷_presenilin-1突变敲入小鼠的免疫调节缺陷
Grant A Morgan,Qing Guo,Sic L Chan et al.
Grant A Morgan et al.
Mutations in the presenilin-1 (PS1) gene are causally linked to early-onset Alzheimer's disease (AD). Studies of neurons suggest that PS1 mutations result in a gain-of-function, which perturbs calcium regulation and increases cell vulnerabi...
Pathomechanism of leukoaraiosis: a molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis) [0.03%]
白质病变发病机制：遗传、生化及临床过程之间的分子纽带（线粒体假说）
Zoltán Szolnoki
Zoltán Szolnoki
Ischemic demyelination in the white matter of the brain is a frequent clinical entity. In neuroimaging terms, it is referred to as leukoaraiosis (LA). LA can reflect a broad public health problem, which is caused by a cognitive impairment r...
Mark P Mattson,Roy G Cutler,Simonetta Camandola
Mark P Mattson
Roy Walford, a physician and scientist who pioneered research on the anti-aging effects of caloric restriction and subjected himself to a low-energy diet, recently died from amyotrophic lateral sclerosis (ALS). Information from his case, ep...
Thomas Korn,Mahendra Rao,Tim Magnus
Thomas Korn
Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinf...