Lipoproteins obtained from anorexia nervosa patients induce higher oxidative stress in U373MG astrocytes through nitric oxide production [0.03%]
厌食症患者的脂蛋白通过产生一氧化氮在星形胶质细胞中诱导更高的氧化应激水平自
Arianna Vignini,Paola Canibus,Laura Nanetti et al.
Arianna Vignini et al.
Eating disorders (ED) are a group of important psychiatric disorders that affect young men and women, and can have serious consequences. Among all ED, anorexia nervosa (AN) is the most typical but also the most severe. The pathogenesis of A...
Andrei Blokhin,Tamara Vyshkina,Samuel Komoly et al.
Andrei Blokhin et al.
Objective: To test if mitochondrial (mt)DNA deletions accumulate in brains of patients with multiple sclerosis (MS). Background: Previo...
DJ-1 is essential for long-term depression at hippocampal CA1 synapses [0.03%]
DJ-1对海马CA1突触的长期抑制是必不可少的
Yue Wang,Jayanth S Chandran,Huaibin Cai et al.
Yue Wang et al.
Mutations in DJ-1 cause inherited Parkinson's disease (PD) in several families. The normal function of DJ-1 is unknown, but mice lacking DJ-1 exhibit a deficit in dopaminergic signaling in the striatum. Since the hippocampus contains relati...
Nicholas Tentolouris,Georgia Argyrakopoulou,Nicholas Katsilambros
Nicholas Tentolouris
The metabolic syndrome is characterized by the clustering of various common metabolic abnormalities in an individual and it is associated with increased risk for the development of type 2 diabetes and cardiovascular diseases. Its prevalence...
Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype [0.03%]
饮食甾醇糖苷的慢性暴露对运动神经元有毒并诱导ALS-PDC表型
R C Tabata,J M B Wilson,P Ly et al.
R C Tabata et al.
Epidemiological studies of the Guamanian variants of amyotrophic lateral sclerosis (ALS) and parkinsonism, amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC), have shown a positive correlation between consumption of washe...
Neurotrophic factors in autonomic nervous system plasticity and dysfunction [0.03%]
自主神经系统的可塑性和功能障碍中的神经营养因子
Mark P Mattson,Ruiqian Wan
Mark P Mattson
During development, neurotrophic factors are known to play important roles in regulating the survival of neurons in the autonomic nervous system (ANS) and the formation of their synaptic connectivity with their peripheral targets in the car...
Tanja Schlereth,Frank Birklein
Tanja Schlereth
The sympathetic nervous system (SNS) and pain interact on many levels of the neuraxis. In healthy subjects, activation of the SNS in the brain usually suppresses pain mainly by descending inhibition of nociceptive transmission in the spinal...
Neurodegenerative diseases: neurotoxins as sufficient etiologic agents? [0.03%]
神经毒物作为神经退行性疾病充分的致病因素吗？
Christopher A Shaw,Günter U Höglinger
Christopher A Shaw
A dominant paradigm in neurological disease research is that the primary etiological factors for diseases such as Alzheimer's (AD), Parkinson's (PD), and amyotrophic lateral sclerosis (ALS) are genetic. Opposed to this perspective are the c...
Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease [0.03%]
帕金森病患者中组胺代谢酶的非同义多态性
José A G Agúndez,Antonio Luengo,Oscar Herráez et al.
José A G Agúndez et al.
Objective: To analyze genetically based impairment in histamine-metabolising enzymes in patients with Parkinson's disease (PD). Methods: ...
The molecular basis of familial dysautonomia: overview, new discoveries and implications for directed therapies [0.03%]
家族性自主神经疾病的研究进展及治疗新策略
Berish Y Rubin,Sylvia L Anderson
Berish Y Rubin
Familial dysautonomia (FD) is a sensory and autonomic neuropathy that affects the development and survival of sensory, sympathetic, and some parasympathetic neurons. It is autosomally inherited and occurs almost exclusively among individual...