Suw Young Ly,Chang Hyun Lee,Young Sam Jung
Suw Young Ly
In this article, we examined the performance of the voltammetric assay of caffeine using DNA immobilized onto a carbon nanotube paste electrode (DPE) and compared it with that of an ordinary carbon nanotube paste electrode (PE). Under optim...
Anne Must,Sulev Kõks,Eero Vasar et al.
Anne Must et al.
Suicidal behavior is a multifactorial phenomenon, with a significant genetic predisposition. To assess the contribution of genes in the 4p region to suicide risk, we genotyped 36 single nucleotide polymorphisms from a 49Mb region on the chr...
Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases [0.03%]
creatine及其在靶向神经退行性疾病细胞能量代谢障碍治疗中的潜在价值
Peter J Adhihetty,M Flint Beal
Peter J Adhihetty
Substantial evidence indicates bioenergetic dysfunction and mitochondrial impairment contribute either directly and/or indirectly to the pathogenesis of numerous neurodegenerative disorders. Treatment paradigms aimed at ameliorating this ce...
Human BDNF isoforms are differentially expressed in cocaine addicts and are sorted to the regulated secretory pathway independent of the Met66 substitution [0.03%]
代谢六六替代物独立于可卡因成瘾者的人BDNF等位基因差异表达并被分类为受调节的秘书路径独立
Xueying Jiang,Jian Zhou,Deborah C Mash et al.
Xueying Jiang et al.
Differential BDNF gene (BDNF) promoter use leads to protein isoforms differing by 8 or 15 N-terminal residues (BDNF1 and BDNF2) whose regulation and function are not completely understood versus the well-known 247-aa BDNF "short" form. To d...
Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat [0.03%]
细胞内质网应激与paraquat诱导多巴胺能神经元死亡之间的联系
Shankar J Chinta,Anand Rane,Karen S Poksay et al.
Shankar J Chinta et al.
Parkinson's disease (PD) features oxidative stress and accumulation of misfolded (unfolded, alternatively folded, or mutant) proteins with associated loss of dopaminergic neurons. Oxidative stress and the accumulated misfolded proteins elic...
Evaled expression of ICAM-1 and its ligands in the rat spinal cord following lipopolysaccharide intraspinal injection [0.03%]
脂多糖腰椎蛛网膜下腔注射大鼠脊髓中ICAM-1及其配体的诱导表达
Junling Yang,Min Fei,Yangyang Gu et al.
Junling Yang et al.
The early stage of inflammation involves the adhesion and transmigration of leukocytes across the blood-brain barrier (BBB) to the normally sequestered central nervous system (CNS). This process is regulated by the expression of a series of...
Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals [0.03%]
氯喹酮与二价金属相互促进β-淀粉样蛋白纤维化生成的作用
Silvia Bolognin,Paolo Zatta,Denise Drago et al.
Silvia Bolognin et al.
As reported by some authors, clioquinol (CQ), a 8-hydroxyquinoline derivative, has produced very encouraging results in the treatment of Alzheimer's disease (AD). Its biological effects are most likely ascribed to complexation of specific m...
Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease [0.03%]
在阿尔茨海默病中变异型α7烟碱乙酰胆碱受体与妄想症状有关
Robyn Carson,David Craig,Dominic Hart et al.
Robyn Carson et al.
Psychotic symptoms are common in Alzheimer's disease (AD) and have a negative impact on quality of life. It is suggested that psychotic symptoms may be attributed to genetic risk factors which are revealed during neurodegeneration. CHRNA7, ...
BACE1 polymorphisms do not influence platelet membrane beta-secretase activity or genetic susceptibility for Alzheimer's disease in the Northern Irish population [0.03%]
BACE1多态性不影响北爱尔兰人群血小板膜β分泌酶活性或阿尔茨海默病的遗传易感性
S Todd,A J McKnight,W W Liu et al.
S Todd et al.
Beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a biological and positional candidate gene for Alzheimer's disease (AD). BACE1 is a protease that catalyses APP cleavage at the beta-secretase site. We evaluated all com...
P Hemachandra Reddy
P Hemachandra Reddy
Mitochondria are key cytoplasmic organelles, responsible for generating cellular energy, regulating intracellular calcium levels, altering the reduction-oxidation potential of cells, and regulating cell death. Increasing evidence suggests t...