No association between polymorphisms of neuronal oxide synthase 1 gene (NOS1) and schizophrenia in a Japanese population [0.03%]
日本人群中神经型一氧化氮合酶1基因多态性与精神分裂症无关联
Takenori Okumura,Tomo Okochi,Taro Kishi et al.
Takenori Okumura et al.
The neuronal nitric oxide synthase gene (NOS1) is located on 12q24, in a susceptibility region for schizophrenia, and produces nitric oxide (NO) in the brain. NO plays a role in neurotransmitter release and is the second messenger of the N-...
Gene dysregulation in Huntington's disease: REST, microRNAs and beyond [0.03%]
亨廷顿病中的基因调控异常：REST、microRNA等的作用
Rory Johnson,Noel J Buckley
Rory Johnson
Huntington's disease (HD) is an incurable, fatal neurodegenerative disorder that is caused by a polyglutamine expansion in the huntingtin (Htt) protein. Neuronal death in the striatum-the most obvious manifestation of the disease-is likely ...
Neil R Smalheiser,Giovanni Lugli
Neil R Smalheiser
microRNAs play an important role in regulating synaptic plasticity. For example, microRNAs target (and are targeted by) plasticity mediators such as CREB, MECP2, and FMRP. As well, specific microRNAs have been shown to be expressed within d...
Decline in daily running distance presages disease onset in a mouse model of ALS [0.03%]
ALS小鼠模型中每日跑步距离的下降预示疾病的发生
Daniel A Bruestle,Roy G Cutler,Richard S Telljohann et al.
Daniel A Bruestle et al.
Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of lower motor neurons resulting in paralysis and death. Epidemiological and clinical findings suggest that a decline in athletic performance may presage the c...
Novel GDAP1 mutation in a Turkish family with CMT2K (CMT2K with novel GDAP1 mutation) [0.03%]
土耳其CMT2K家系的GDAP1新突变(CMT2K伴随新的GDAP1突变)
Nilufer Sahin-Calapoglu,Meliha Tan,Mustafa Soyoz et al.
Nilufer Sahin-Calapoglu et al.
Mutations in the ganglioside-induced differentiation-associated protein 1 gene (GDAP1) cause Charcot-Marie-Tooth type 2 (CMT2), a severe autosomal recessive form of neuropathy associated with axonal phenotypes. It has been screened in this ...
Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo [0.03%]
早期生长反应第1基因介导了体外培养的小胶质细胞活化，但在体内则无此作用
Thomas Langmann,Stefanie Ebert,Yana Walczak et al.
Thomas Langmann et al.
We have previously identified activation of microglia and induction of the early growth response gene 1 (Egr1) in the retina of retinoschisin-deficient (Rs1h(-/Y)) mice. We hypothesized that microglial expression of Egr1 might support retin...
CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients [0.03%]
CLOCK可能预测氟伏沙明治疗日本抑郁症患者的疗效
Taro Kishi,Tsuyoshi Kitajima,Masashi Ikeda et al.
Taro Kishi et al.
Recent studies have shown that selective serotonin reuptake inhibitors (SSRIs) have circadian properties, suggesting that the antidepressive action of SSRIs may also be attributable to circadian mechanisms. Another study reported an associa...
AAV-mediated local delivery of interferon-beta for the treatment of retinoblastoma in preclinical models [0.03%]
利用AAV介导的局部递送干扰素β治疗视网膜母细胞瘤的小鼠模型中预实验阶段的治疗
Chie-Schin Shih,Nikia Laurie,Jeremy Holzmacher et al.
Chie-Schin Shih et al.
Interferon-beta (IFN-beta) has been found to have anti-tumor properties against a variety of malignancies through different mechanisms. However, clinical trials involving systemic administration of IFN-beta have been hampered by secondary t...
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons [0.03%]
烟酰胺可防止NAD+耗竭并保护神经元免受兴奋性毒性和脑缺血的侵害：SIRT1对NAD+的消耗可能危及能量衰弱的神经元
Dong Liu,Robert Gharavi,Michael Pitta et al.
Dong Liu et al.
Neurons require large amounts of energy to support their survival and function, and are therefore susceptible to excitotoxicity, a form of cell death involving bioenergetic stress that may occur in several neurological disorders including s...
Albert Y Sun,Qun Wang,Agnes Simonyi et al.
Albert Y Sun et al.
The high demand for molecular oxygen, the enrichment of polyunsaturated fatty acids in membrane phospholipids, and the relatively low abundance of antioxidant defense enzymes are factors rendering cells in the central nervous system (CNS) p...