Gokhan Yilmaz,D Neil Granger
Gokhan Yilmaz
Leukocytes are recruited into the cerebral microcirculation following an ischemic insult. The leukocyte-endothelial cell adhesion manifested within a few hours after ischemia (followed by reperfusion, I/R) largely reflects an infiltration o...
Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery [0.03%]
雌激素对雄性大鼠垂体的新生儿内分泌效应：早期促性腺激素耗竭后恢复长期效果
Bronwen Martin,Stuart Maudsley,Judith McNeilly et al.
Bronwen Martin et al.
Neonatal exposure to potent estrogenic compounds can affect multiple components of the male reproductive system causing impaired development of the epithelium and overgrowth of stromal tissue in the epididymis, vas deferens, seminal vesicle...
Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity [0.03%]
β淀粉样蛋白通过半胱天冬酶介导P2X4剪切促进嘌呤毒性的产生
R Varma,Y Chai,J Troncoso et al.
R Varma et al.
Overproduction of the beta-amyloid fragment 1-42 (A beta(1-42)) is thought to contribute to synaptic dysfunction and neuronal death in Alzheimer's disease. Mounting evidence suggests that purinergic receptors play critical roles in synaptic...
A J Larner
A J Larner
Epileptic seizures have long been recognised as a complication of the clinical syndrome of Alzheimer's disease, particularly in advanced disease, but have hitherto been viewed essentially as epiphenomena of the neurodegenerative process. Pr...
Alan R Hipkiss
Alan R Hipkiss
It has been shown that NAD(+) availability is important for neuronal survival following ischemia (Liu et al., Neuromolecular Med 11:28-42, 2009). It is proposed here that NAD(+) may also control proteotoxicity by influencing both formation ...
Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population [0.03%]
日籍人群情绪障碍与促动力素受体基因(PROKR2)的关联性分析
Taro Kishi,Tsuyoshi Kitajima,Tomoko Tsunoka et al.
Taro Kishi et al.
Several investigations have suggested that disruption of circadian rhythms may provide the foundation for the development of mood disorders such as bipolar disorder (BP) and major depressive disorder (MDD). Recent animal studies reported th...
MicroRNAs in mental health: from biological underpinnings to potential therapies [0.03%]
微小核糖核酸与心理健康：从生物学基础到潜在疗法
Joshua G Hunsberger,Daniel R Austin,Guang Chen et al.
Joshua G Hunsberger et al.
Psychiatric illnesses are disabling disorders with poorly understood underlying pathophysiologies. However, it is becoming increasingly evident that these illnesses result from disruptions across whole cellular networks rather than any part...
Jannet Kocerha,Sakari Kauppinen,Claes Wahlestedt
Jannet Kocerha
In recent years, there has been a shift in the conventional paradigms for transcriptional and translational regulation as extensive sequencing efforts have yielded new insights into the landscape of the human genome and transcriptome. Hundr...
A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis [0.03%]
线粒体解偶联蛋白4纯合子基因变异对多发性硬化的保护作用
Zoltan Szolnoki,Andras Kondacs,Yvette Mandi et al.
Zoltan Szolnoki et al.
Multiple sclerosis (MS), which results in damage of the white matter at multiple foci, poses a far-reaching public health problem in view of the burden it imposes on the affected young and middle-aged. Some previous data suggested that role...
Janusz K Rybakowski,Maria Skibinska,Anna Leszczynska-Rodziewicz et al.
Janusz K Rybakowski et al.
Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g., cancer and heart disease). Recently, MMP-9 has been implicated in various aspects of brain functions (e.g., neuroplasticity and epileptogenesis) and thus...