Dietary supplementation with S-adenosyl methionine delays the onset of motor neuron pathology in a murine model of amyotrophic lateral sclerosis [0.03%]
甲硫氨酸饮食补充可延缓肌萎缩侧索硬化小鼠模型中运动神经元病理变化的出现
James Suchy,Sangmook Lee,Ambar Ahmed et al.
James Suchy et al.
The full range of causative factors in Amyotrophic lateral sclerosis (ALS) remains elusive, but oxidative stress is recognized as a contributing factor. Mutations in Cu/Zn superoxide dismutase 1 (SOD-1), associated with familial ALS, promot...
Tomas Ondrejcak,Igor Klyubin,Neng-Wei Hu et al.
Tomas Ondrejcak et al.
Alzheimer's disease (AD) is characterized neuropathologically by the deposition of different forms of amyloid beta-protein (A beta) including variable amounts of soluble species that correlate with severity of dementia. The extent of synapt...
Joachim Silber,C David James,J Graeme Hodgson
Joachim Silber
Gliomas are the most common form of primary brain tumors and are associated with a poor clinical outcome. The molecular mechanisms that contribute to gliomagenesis have become increasingly clear in recent years, yet much remains to be learn...
Xuekun Li,Peng Jin
Xuekun Li
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mR...
Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population [0.03%]
RTN3和PPIL2基因多态性与北爱尔兰人群中血小板膜β-分泌酶活性及阿尔茨海默病易感性的关联分析
Robyn Carson,Amy Jayne McKnight,Stephen Todd et al.
Robyn Carson et al.
Beta-site amyloid precursor protein cleaving enzyme (BACE1) is the rate-limiting enzyme for production of beta-amyloid peptides (Abeta), which are proposed to drive the pathological changes found in Alzheimer's disease (AD). Reticulon 3 (RT...
Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease [0.03%]
α-突触核蛋白与金属离子的相互作用，在帕金森病发病机制中的作用仍在探寻中
Marco Bisaglia,Isabella Tessari,Stefano Mammi et al.
Marco Bisaglia et al.
The most recent literature on the interaction between alpha-synuclein in its several aggregation states and metal ions is discussed. This analysis shows two major types of interactions. Binding sites are present in the C-terminal region, an...
Manganese and its role in Parkinson's disease: from transport to neuropathology [0.03%]
锰及其在帕金森病中的作用：从转运到神经病理学
Michael Aschner,Keith M Erikson,Elena Herrero Hernández et al.
Michael Aschner et al.
The purpose of this review is to highlight recent advances in the neuropathology associated with Mn exposures. We commence with a discussion on occupational manganism and clinical aspects of the disorder. This is followed by novel considera...
Mohammad T Alsuwaidan,Aaron Kucyi,Candy W Y Law et al.
Mohammad T Alsuwaidan et al.
Extant evidence indicates that individuals with bipolar disorder (BD) are differentially affected by overweight/obesity and abdominal obesity. Excess weight is associated with a more complex illness presentation, non-recovery, and recurrenc...
Interleukin-1 beta -511C/T genetic polymorphism is associated with age of onset of geriatric depression [0.03%]
白细胞介素-1β-511C/T基因多态性与老年抑郁症发病年龄的关系研究
Jen-Ping Hwang,Shih-Jen Tsai,Chen-Jee Hong et al.
Jen-Ping Hwang et al.
The pro-inflammatory cytokine interleukin-1 beta has been implicated in the pathogenesis of major depressive disorder and in cognitive function decline in the elderly. This study tests the hypothesis that a biallelic functional polymorphism...
Changmei Liu,Xinyu Zhao
Changmei Liu
Neurogenesis is defined as a process that includes the proliferation of neural stem/progenitor cells (NPCs) and the differentiation of these cells into new neurons that integrate into the existing neuronal circuitry. MicroRNAs (miRNAs) are ...