Current Status of Research on Nanomaterials Combined with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke [0.03%]
纳米材料结合间充质干细胞治疗缺血性卒中的研究进展
Qingxue Xu,Lijuan Gu,Zhiyang Li et al.
Qingxue Xu et al.
Ischemic stroke (IS) is a disease with high mortality and disability rates worldwide and is a serious threat to patient health. Owing to the narrow therapeutic window, effective treatments during the recovery period are limited. However, in...
Schizophrenia Biomarkers: Blood Transcriptome Suggests Two Molecular Subtypes [0.03%]
精神分裂症生物标志物：血液转录组表明存在两种分子亚型
Herut Dor,Libi Hertzberg
Herut Dor
Schizophrenia is a chronic illness that imposes a significant burden on patients, their families, and the health care system. While it has a substantial genetic component, its heterogeneous nature-both genetic and clinical-limits the abilit...
Microparticles Mediate Lipopolysaccharide-induced Inflammation and Chronic Pain in Mouse Model [0.03%]
微粒介导大肠杆菌内毒素诱导的小鼠炎症和慢性疼痛
Anjali Singh,Khushi,Vinod Tiwari et al.
Anjali Singh et al.
Recent evidence highlights microparticles (MPs) as crucial players in intercellular communication among immune cells, yet their role in inflammation-induced chronic pain remains unexplored. In this study, we investigated the involvement of ...
Transcriptomic Profiling Reveals Sex-Specific Epigenetic Dynamics Involving kdm6b and H3K27 Methylation in Cerebral Ischemia-Induced Neurogenesis and Recovery [0.03%]
转录组谱分析揭示了涉及kdm6b和H3K27甲基化的性别特异性表观遗传动力学在脑缺血诱导的神经发生和恢复中的作用
Mydhili Radhakrishnan,Aditya Undru,Shashikant Patel et al.
Mydhili Radhakrishnan et al.
Cerebral ischemic stroke ranks among the leading causes of death and disability worldwide. A significant challenge, beyond the lack of effective therapies, is the frequent oversight of sex as a vital factor in stroke research. This study fo...
Noradrenergic Projections from the Locus Coeruleus to the Medial Prefrontal Cortex Enhances Stress Coping Behavior in Mice Following Long-Term Intermittent Fasting [0.03%]
蓝斑投射到前额叶皮层的去甲肾上腺素能神经元促进间歇性禁食小鼠的压力应对行为
Zheng Zhao,Jun-Liang Chen,Han Zhan et al.
Zheng Zhao et al.
Intermittent fasting has been shown to alleviate stress, anxiety, and depressive symptoms. Although noradrenaline, also known as norepinephrine (NE), is implicated in stress regulation, the dynamics of NE release and the associated neural p...
STAT3 Inhibitor Increases α-Synuclein in PFF-Treated Astroglia Cells by Dysregulating Autophagy and Potentially Affects Exosome Biogenesis [0.03%]
STAT3抑制剂通过调控自噬影响α-突触核蛋白的分泌及其对朊毒体处理星形胶质细胞的影响研究
Yangfu Luo,Nailiang Zang,Yuting Tang et al.
Yangfu Luo et al.
Astrocytes are the most abundant cells in the brain and show neuroprotective function in CNS and reactive astrocytes are characteristic in neurodegenerative diseases. The JAK2-STAT3 pathway plays a crucial role in the process of astrocyte a...
Unraveling the Nexus: The Role of Collapsin Response Mediator Protein 2 Phosphorylation in Neurodegeneration and Neuroregeneration [0.03%]
解开联系： collapsin应答调节介质蛋白2磷酸化在神经退行性疾病和神经再生中的作用
Yuebing Wang,Toshio Ohshima
Yuebing Wang
Neurodegenerative disease characterized by the progressive damage of the nervous system, and neuropathies caused by the neuronal injury are both led to substantial impairments in neural function and quality of life among geriatric populatio...
USP15 as a Potential Therapeutic Target in Cerebral Ischemia: Modulation of Ferroptosis and Cognitive Dysfunction via the Nrf2/GPX4 Axis in Mice [0.03%]
USP15在脑缺血中作为潜在的治疗靶点通过Nrf2/GPX4信号轴调节铁死亡和认知障碍小鼠模型中的作用机制研究
Haoran Yi,Xingpeng Xiao,Fan Lei et al.
Haoran Yi et al.
This study aimed to investigate the role of ubiquitin-specific peptidase 15 (USP15) in ischemic cognitive dysfunction using a mouse model and a cerebral ischemia (CI) cell model, its impact on ferroptosis and the underlying mechanisms. Oxyg...
Anthropometric and Demographic Features Affect the Interpretation of Cerebrospinal Fluid Biomarkers in Patients with Different Dementia Syndromes and Cognitively Healthy Adults [0.03%]
人体测量和人口统计学特征会影响不同痴呆综合征患者和认知健康成年人脑脊液生物标志物的解读
Fabricio Ferreira de Oliveira,Marjorie Câmara Miraldo,Eduardo Ferreira de Castro-Neto et al.
Fabricio Ferreira de Oliveira et al.
Clinical distinction between dementia with Lewy bodies (DLB) and late-onset Alzheimer's disease (AD) is difficult, while several features might affect the analyses of biomarkers. This study aimed to verify associations of anthropometric and...
Distinct Hippocampal Expression Profiles of lncRNAs in Obese Type 2 Diabetes Mice Exhibiting Cognitive Impairment [0.03%]
肥胖型2型糖尿病小鼠海马区长链非编码RNA的差异表达谱分析
Qianqian Xu,Lihui Wang,Qiong Song et al.
Qianqian Xu et al.
Cognitive dysfunction has been accepted as a possible complication of type 2 diabetes (T2D), but few studies revealed the potential roles of Long non‑coding RNAs (lncRNAs) in cognitive dysfunction in T2D. The current research aims to demon...