José A Botella,Florian Bayersdorfer,Florian Gmeiner et al.
José A Botella et al.
The recent discovery of a number of genes involved in familial forms of Parkinson's disease (PD) has moved the use of model genetic organisms to the frontline. One avenue holding tremendous potential to find therapies against human diseases...
Eitan Okun,Mark P Mattson,Thiruma V Arumugam
Eitan Okun
Immunoglobulins are proteins with a highly variable antigen-binding domain and a constant region (Fc domain) that binds to a cell surface receptor (FcR). Activation of FcRs in immune cells (lymphocytes, macrophages, and mast cells) triggers...
Sara Landgren,Mona Seibt Palmér,Ingemar Skoog et al.
Sara Landgren et al.
The vascular hypothesis of Alzheimer's disease (AD) has brought the vascular endothelial growth factor (VEGF) into focus. The genomic region including the VEGF gene has been linked to AD and single nucleotide polymorphisms (SNPs) of the VEG...
Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin? [0.03%]
阿尔茨海默病中的突触抑制和异常兴奋性网络活动：一枚硬币的两面？
Jorge J Palop,Lennart Mucke
Jorge J Palop
Neurodegenerative diseases, including Alzheimer's disease (AD), target specific and functionally connected neuronal networks, raising the possibility that neurodegeneration may spread through abnormal patterns of neural network activity. AD...
A clear and present danger: endogenous ligands of Toll-like receptors [0.03%]
近在眼前的危险： toll样受体的内源性配体
Jacob A Sloane,Daina Blitz,Zachary Margolin et al.
Jacob A Sloane et al.
Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes extensively to neurologic injury. With more recent focus on innat...
Paraoxonase 1 polymorphisms are not related with the risk for multiple sclerosis [0.03%]
ParaOxN1多态性与多发性硬化症的风险无关
Carmen Martínez,Elena García-Martín,Julián Benito-León et al.
Carmen Martínez et al.
It has been suggested a possible role of oxidative stress and lipid peroxidation in the inflammatory processes and in the pathogenesis of multiple sclerosis. Human serum paraoxonase 1 is a polymorphic enzyme encoded by the gene PON1, locate...
The role of the complement system and the activation fragment C5a in the central nervous system [0.03%]
补体系统及其激活片段C5a在中枢神经系统中的作用
Trent M Woodruff,Rahasson R Ager,Andrea J Tenner et al.
Trent M Woodruff et al.
The complement system is a pivotal component of the innate immune system which protects the host from infection and injury. Complement proteins can be induced in all cell types within the central nervous system (CNS), where the pathway seem...
The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair [0.03%]
microRNA在神经系统损伤、退行及修复中的治疗潜力
Emmette R Hutchison,Eitan Okun,Mark P Mattson
Emmette R Hutchison
MicroRNAS (miRNAs) have been suggested to play important roles in the central nervous system during development as well as disease. miRNAs appear to be dysregulated in a number of neurodegenerative diseases, developmental disorders, and as ...
Translin-associated factor X gene (TSNAX) may be associated with female major depressive disorder in the Japanese population [0.03%]
在日本人群中TRANSLIN相关因子X基因（TSNAX）可能与女性抑郁症有关
Akiko Okuda,Taro Kishi,Tomo Okochi et al.
Akiko Okuda et al.
Several investigations have reported that the translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) was associated with major psychiatric disorders including schizophrenia, bipolar disorder (BP), and major depr...
Are there common biochemical and molecular mechanisms controlling manganism and parkisonism [0.03%]
锰中毒和帕金森病的生化及分子机制是否相同
Jerome A Roth
Jerome A Roth
Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder known as manganism is associated with the preferential accumulation of Mn in the...