From manganism to manganese-induced parkinsonism: a conceptual model based on the evolution of exposure [0.03%]
从药物诱导的帕金森氏症到锰诱导的帕金森氏症：基于暴露演变的概念模型
Roberto G Lucchini,Christopher J Martin,Brent C Doney
Roberto G Lucchini
Manganism is a distinct medical condition from Parkinson's disease. Manganese exposure scenarios in the last century generally have changed from the acute, high-level exposure conditions responsible for the occurrence of manganism to chroni...
Silvia Bolognin,Luigi Messori,Paolo Zatta
Silvia Bolognin
Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the biochemical mechanisms of metal involvement in NDs is still largely u...
Sarah M Rothman,Mark P Mattson
Sarah M Rothman
Recent clinical data have implicated chronic adverse stress as a potential risk factor in the development of Alzheimer's disease (AD) and data also suggest that normal, physiological stress responses may be impaired in AD. It is possible th...
A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury [0.03%]
慢性压迫损伤后SRC抑制的蛋白激酶底物在大鼠星形胶质细胞中起关键作用
Yinyin Xia,Haiou Liu,Aiguo Shen et al.
Yinyin Xia et al.
Src-suppressed C kinase substrate (SSeCKS), is an in vivo and in vitro protein kinase C substrate that may have a role in both mitogenic regulation and cytoskeletal arrangement. In this study, we mainly investigated the mRNA and protein exp...
HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort [0.03%]
五-HT2A基因与日本抑郁症患者抗抑郁药疗效的关系研究
Taro Kishi,Reiji Yoshimura,Tsuyoshi Kitajima et al.
Taro Kishi et al.
Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of H...
Shusuke Numata,Masahito Nakataki,Jun-ichi Iga et al.
Shusuke Numata et al.
Disrupted-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia (SZ) and major depressive disorder (MDD), interacts with several proteins and some of them are reported to be genetically associated with SZ. Pericentrin (P...
Kinesin light chain 1 gene haplotypes in three conformational diseases [0.03%]
三种构型性疾病中的动力蛋白轻链1基因的单体型
Malin von Otter,Sara Landgren,Staffan Nilsson et al.
Malin von Otter et al.
A functional intracellular transport system is essential to maintain cell shape and function especially in elongated cells, e.g. neurons and lens fibre cells. Impaired intracellular transport has been suggested as a common pathological mech...
Robert A Yokel
Robert A Yokel
Manganese (Mn) is essential for brain growth and metabolism, but in excess can be a neurotoxicant. The chemical form (species) of Mn influences its kinetics and toxicity. Significant Mn species entering the brain are the Mn(2+) ion and Mn c...
Marc Gleichmann,Mark P Mattson
Marc Gleichmann
The amyloid beta-peptide theory of Alzheimer's Disease has helped to advance our understanding of the disease tremendously. A new area of research focuses on the changes in neuronal network activity that take place and may contribute to the...
Phospholipases A2 and inflammatory responses in the central nervous system [0.03%]
磷脂酶A2和中枢神经系统的炎症反应
Grace Y Sun,Phullara B Shelat,Michael B Jensen et al.
Grace Y Sun et al.
Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to play multiple roles for maintenance of membrane phospholipid homeostasis and...