Dimebon inhibits calcium-induced swelling of rat brain mitochondria but does not alter calcium retention or cytochrome C release [0.03%]
Dimebon抑制钙引起的雄性Sprague-Dawley大鼠脑线粒体肿胀，但不影响钙滞留或细胞色素C释放
Kranthi Kumari Naga,James W Geddes
Kranthi Kumari Naga
Dimebon was originally introduced as an antihistamine and subsequently investigated as a possible therapeutic for a variety of disorders, including Alzheimer's disease. One putative mechanism underlying the neuroprotective properties of Dim...
Mark P Mattson
Mark P Mattson
He spent tens of thousands of hours peering through the oculars of a microscope at stained brain tissue sections from thousands of patients who died with or without a neurodegenerative disorder; most of those patients he had himself cared f...
D Stephen Snyder
D Stephen Snyder
Arundhati Jana,Kalipada Pahan
Arundhati Jana
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the CNS. Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are target cells in MS. Although the etiology of MS is poorly known, new insig...
Oxidative stress in Alzheimer disease: synergy between the Butterfield and Markesbery laboratories [0.03%]
阿尔茨海默病的氧化应激：Butterfield和Markesbery实验室研究的协同作用
D Allan Butterfield
D Allan Butterfield
Creighton H Phelps
Creighton H Phelps
Association study of TRPC4 as a candidate gene for generalized epilepsy with photosensitivity [0.03%]
TRPC4通道蛋白与光敏感性全面性癫痫的关联研究
Sarah von Spiczak,Hiltrud Muhle,Ingo Helbig et al.
Sarah von Spiczak et al.
Photoparoxysmal response (PPR) is characterized by abnormal visual sensitivity of the brain to photic stimulation. Frequently associated with idiopathic generalized epilepsies (IGEs), it might be an endophenotype for cortical excitability. ...
Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? [0.03%]
阿尔茨海默病中的鞘脂代谢途径变化：新的生物标志物和治疗靶点？
Michelle M Mielke,Constantine G Lyketsos
Michelle M Mielke
The public health burden of Alzheimer disease (AD), the most common neurodegenerative disease, threatens to explode in the middle of this century. Current FDA-approved AD treatments (e.g. cholinesterase inhibitors, NMDA-receptor agonists) d...
Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses [0.03%]
哺乳动物中性鞘氨醇基磷脂酰胆碱酶：调控及细胞信号转导中的作用
Bill X Wu,Christopher J Clarke,Yusuf A Hannun
Bill X Wu
Ceramide, a bioactive lipid, has been extensively studied and identified as an essential bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase (SMase), (EC 3.1.4.12) catalyzes the cleavage of the phosphodiester bond ...
Mark A Lovell
Mark A Lovell