The 894G > T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline [0.03%]
内皮型一氧化氮合酶基因的894G>T（Glu298Asp）变异体和MTHFR基因多态性影响认知功能下降患者的同型半胱氨酸水平
Nadia Ferlazzo,Gaetano Gorgone,Daniela Caccamo et al.
Nadia Ferlazzo et al.
The presence and severity of cerebrovascular pathological findings have been shown to increase the risk and stage of cognitive decline observed in Alzheimer's disease and vascular dementia. Thus, the modification of vascular risk factors se...
Mark P Mattson
Mark P Mattson
A recent editorial entitled "State of Aggregation" (Nat. Neurosci. 2011; 14:399) described the importance of establishing the structural state of pathogenic protein aggregates (Aβ, α-synuclein, huntingtin, etc.) in studies of neurodegener...
Cerebrospinal fluid microglial markers in Alzheimer's disease: elevated chitotriosidase activity but lack of diagnostic utility [0.03%]
阿尔茨海默病脑脊液小胶质细胞标志物：粘多糖苷酶活性升高但无诊断价值
Niklas Mattsson,Shahrzad Tabatabaei,Per Johansson et al.
Niklas Mattsson et al.
Activated microglial cells, which are the resident macrophages of the central nervous system, surround amyloid β-plaques in Alzheimer's disease (AD) brains. Inflammation including microglial activation may contribute in AD pathogenesis, an...
Alexandra Abramsson,Sara Landgren,Madeleine Zetterberg et al.
Alexandra Abramsson et al.
Aggregation of amyloid-beta is one of the major characteristics in brains of patients with Alzheimer's disease (AD). Although several mechanisms behind the formation of such aggregates have been suggested the regulatory factors are still un...
Analysis of structural and molecular events associated with adult rat optic chiasm and nerves demyelination and remyelination: possible role for 3rd ventricle proliferating cells [0.03%]
成人大鼠视交叉和神经脱髓鞘及再髓鞘形成相关结构和分子事件的研究：第3脑室增殖细胞的可能作用
Sabah Mozafari,Mohammad Javan,Mohammad Amin Sherafat et al.
Sabah Mozafari et al.
Multiple sclerosis frequently affects the optic apparatus, particularly optic chiasm and nerves. Here, we have reported the structural and molecular characteristics of remyelination in the adult rat optic chiasm and nerves. Moreover, consid...
CALM, a clathrin assembly protein, influences cell surface GluR2 abundance [0.03%]
黏着素CALM影响细胞表面谷氨酸受体亚基GluR2含量
Asaff Harel,Mark P Mattson,Pamela J Yao
Asaff Harel
The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles. In a previous study, we showed that CALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis...
Mood disorders and obesity: understanding inflammation as a pathophysiological nexus [0.03%]
情绪障碍与肥胖：从病理生理角度理解炎症之间的联系
Joanna K Soczynska,Sidney H Kennedy,Hanna O Woldeyohannes et al.
Joanna K Soczynska et al.
The aim of this review is to evaluate the evidentiary base supporting the hypothesis that the increased hazard for obesity in mood disorder populations (and vice versa) is a consequence of shared pathophysiological pathways. We conducted a ...
Claudia Balducci,Gianluigi Forloni
Claudia Balducci
Alzheimer's disease is the most widespread form of dementia. Its histopathological hallmarks include vascular and extracellular β-amyloid (Aβ) deposition and intraneuronal neurofibrillary tangles (NFTs). Gradual decline of cognitive funct...
Mutations in the survival motor neuron (SMN) protein alter the dynamic nature of nuclear bodies [0.03%]
突变型Survival Motor Neuron(SMN)蛋白改变核体内在动态性质
Robert Morse,Adrian G Todd,Debra J Shaw et al.
Robert Morse et al.
The childhood disorder spinal muscular atrophy (SMA) is caused by reduced expression of the survival motor neuron (SMN) protein. SMN is a multifunctional protein that has been implicated in the production, processing and transport of RNA an...
Pawel M Switonski,Agnieszka Fiszer,Katarzyna Kazmierska et al.
Pawel M Switonski et al.
Spinocerebellar ataxia 3 (SCA3) is a genetic disorder resulting from the expansion of the CAG repeats in the ATXN3 gene. The pathogenesis of SCA3 is based on the toxic function of the mutant ataxin-3 protein, but the exact mechanism of the ...