Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment [0.03%]
长期非典型抗精神病治疗的 schizophrenia 患者中脑源性神经营养因子基因多态性与体重变化的关系研究
Ashley Tsai,Ying-Jay Liou,Chen-Jee Hong et al.
Ashley Tsai et al.
Schizophrenic patients treated with atypical antipsychotics (AAPs) often develop excessive body weight gain, which may lead to further morbidity and poor treatment compliance. This study examined whether genetic variants in the brain-derive...
Zhiyou Cai,Bin Zhao,Anna Ratka
Zhiyou Cai
Oxidative stress has been proposed to be an important factor in the pathogenesis of Alzheimer's disease (AD) and contributed to β-amyloid (Aβ) generation. Interaction between oxidative stress and neuro-inflammation leads to Aβ generation...
Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond [0.03%]
脑源性神经营养因子与阿尔茨海默病：生理病理及其他方面
Breno Satler Diniz,Antonio Lucio Teixeira
Breno Satler Diniz
Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system where it plays several pivotal roles in synaptic plasticity and neuronal survival. As a consequence, BDNF became a key target...
Characterisation of ATM mutations in Slavic Ataxia telangiectasia patients [0.03%]
斯拉夫遗传性共济失调毛细血管扩张症患者的ATM突变表征
Jana Soukupova,Petr Pohlreich,Eva Seemanova
Jana Soukupova
Ataxia telangiectasia (AT) is a genomic instability syndrome characterised, among others, by progressive cerebellar degeneration, oculocutaneous telangiectases, immunodeficiency, elevated serum alpha-phetoprotein level, chromosomal breakage...
No association of angiotensin I converting enzyme I/D polymorphism with domain-specific cognitive function in aged men without dementia [0.03%]
血管紧张素转换酶I/D基因多态性与无痴呆老年男性特定领域认知功能无关
Mu-En Liu,Shih-Jen Tsai,Ti Lu et al.
Mu-En Liu et al.
Previous research studies have related the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene to cognitive function in various neuropsychiatric or neurodegenerative disorders, but not yet investigated it...
D Ekuni,T Tomofuji,K Irie et al.
D Ekuni et al.
Amyloid-β plays a causative role in Alzheimer's disease. Occlusal disharmony causes chronic psychological stress, and psychological stress increases amyloid-β accumulation. The purpose of the present study was to investigate whether occlu...
Temporal and spatial expression of cyclin H in rat spinal cord injury [0.03%]
大鼠脊髓损伤后cyclin H的时空表达式研究
Gang Wu,Jianhua Cao,Chen Peng et al.
Gang Wu et al.
Cyclin H regulates cell cycle transitions; it always forms trimeric cyclin-dependent protein kinases (CDK)-activating kinase (CAK) complex with CDK7 and MAT1 that phosphorylates a threonine residue in the CDK2 T loop region. However, neithe...
Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke [0.03%]
ANGPTL3、CILP2和TRIB1位点的TG水平影响变异与缺血性卒中的关联研究
Luca Járomi,Veronika Csöngei,Noémi Polgár et al.
Luca Járomi et al.
Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of...
Energy restriction negates NMDA receptor antagonist efficacy in ischemic stroke [0.03%]
能量限制消除N-甲基-D天冬氨酸受体拮抗剂在缺血性脑卒中中的疗效
Jeong Seon Yoon,Mohamed R Mughal,Mark P Mattson
Jeong Seon Yoon
Preclinical evaluation of drugs for neurological disorders is usually performed on overfed rodents, without consideration of how metabolic state might affect drug efficacy. Using a widely employed mouse model of focal ischemic stroke, we fo...