Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis [0.03%]
白介素6基因多态性与神经精神疾病关联及功能研究：整合生物信息学和Meta分析的视角
Md Harun-Or-Roshid,Md Nurul Haque Mollah,Jesmin
Md Harun-Or-Roshid
Interleukin 6 (IL6) is an inflammatory biomarker linked to central and peripheral nervous system diseases. This study combined bioinformatics and statistical meta-analysis to explore potential associations between IL6 gene variants (rs18007...
Meta-Analysis
Neuromolecular medicine. 2025 Jan 15;27(1):9. DOI:10.1007/s12017-025-08831-7 2025
HERC5/ISG15 Enhances Glioblastoma Stemness and Tumor Progression by mediating SERBP1protein stability [0.03%]
HERC5/ISG15通过介导SERBP1蛋白稳定性增强胶质母细胞瘤干细胞特性及肿瘤进展
Zhixiao Li,Rongjun Qian,Mengda Li et al.
Zhixiao Li et al.
Glioblastoma (GBM) is the most common malignant brain tumor, and has a low survival rate and a poor prognosis. Intensive studies of pathogenic mechanisms are essential for exploring therapeutic targets for GBM. In this study, the roles play...
Neuroprotective Effects of Sodium Nitroprusside on CKD-Induced Cognitive Dysfunction in Rats: Role of CBS and Nrf2/HO-1 Pathway [0.03%]
NaNO治疗对慢性肾脏病大鼠认知功能损伤的神经保护作用及CBS和Nrf2/HO-1通路的作用机制研究
Zeinab Hamidizad,Mehri Kadkhodaee,Farzaneh Kianian et al.
Zeinab Hamidizad et al.
Chronic kidney disease (CKD) is a conceivable new risk factor for cognitive disorder and dementia. Uremic toxicity, oxidative stress, and peripheral-central inflammation have been considered important mediators of CKD-induced nervous disord...
From Genes to Metabolites: HSP90B1's Role in Alzheimer's Disease and Potential for Therapeutic Intervention [0.03%]
从基因到代谢物：HSP90B1在阿尔茨海默病中的作用及潜在治疗干预可能性
Cheng Huang,Ying Liu,Shuxin Wang et al.
Cheng Huang et al.
Alzheimer's disease (AD) is a prototypical neurodegenerative disorder, predominantly affecting individuals in the presenile and elderly populations, with an etiology that remains elusive. This investigation aimed to elucidate the alteration...
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society [0.03%]
想像，探索，启发——第4届21三体综合症国际大会论文集
Lisi Flores-Aguilar,Eric D Hamlett,Paula Araya et al.
Lisi Flores-Aguilar et al.
Down syndrome (DS) or trisomy 21 (T21) is present in a significant number of children and adults around the world and is associated with cognitive and medical challenges. Through research, the T21 Research Society (T21RS), established in 20...
NSUN2-Mediated RNA 5-Methylcytosine Modification of PTEN Regulates Cognitive Impairments of Mice with Sleep Deprivation and Autophagy Through PI3K/AKT Signaling [0.03%]
NSUN2介导的PTEN RNA 5-甲基胞嘧啶修饰通过PI3K / AKT信号调节睡眠剥夺小鼠的认知障碍和自噬作用
Gangli Yan,Yan Xu,Xiaobin Xing et al.
Gangli Yan et al.
Sleep deprivation (SD) impairs learning and memory. Investigating the role of epigenetic modifications, such as 5-methylcytosine (m5C), in SD is crucial. This study established an SD mouse model and assessed the mRNA levels of m5C-related g...
Differential Expression of GABA Receptor-Related Genes in Alzheimer's Disease and the Positive Regulatory Role of Aerobic Exercise-From Genetic Screening to D-gal-induced AD-like Pathology Model [0.03%]
阿尔茨海默病中GABA受体相关基因的差异表达及有氧运动的正向调节作用：从遗传筛选到D-半乳糖致AD样病理模型研究
Yang Liu,Haoran Peng,Qi Liu et al.
Yang Liu et al.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. The neuropathology of AD appears in the hippocampus. The purpose of this work was to reveal key differentially expressed genes (DEGs) in the hippocampus of AD patients ...
IL-6 Promotes Muscle Atrophy by Increasing Ubiquitin-Proteasome Degradation of Muscle Regeneration Factors After Cerebral Infarction in Rats [0.03%]
缺血性脑卒大鼠肌肉萎缩的机制研究及其干预措施诱导肌肉再生因素降解的作用机制研究
Fangyu Chen,Juanjuan Fu,Hui Feng
Fangyu Chen
Muscle atrophy in pathological or diseased muscles arises from an imbalance between protein synthesis and degradation. Elevated levels of interleukin-6 (IL-6) are a hallmark of ischemic stroke and have been associated with muscle atrophy in...
The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer's Disease [0.03%]
阿尔茨海默病中淀粉样蛋白和tau蛋白蓄积、PANoptosis及炎症之间的相互作用
Xianbo Zhuang,Jie Lin,Yamin Song et al.
Xianbo Zhuang et al.
Alzheimer's disease (AD) is a common progressive neurodegenerative disorder, and the vast majority of cases occur in elderly patients. Recently, the accumulation of Aβ and tau proteins has drawn considerable attention in AD research. This ...
Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death [0.03%]
近年来microRNA介导的神经元分化和死亡调节的新进展
Somi Patranabis
Somi Patranabis
The review aims to focus on the role of miRNA in gene regulation, related to differentiation and apoptosis of neurons, focusing on the array of miRNAs involved in the processes. miRNAs are a known class of small regulatory RNAs, which in as...