RVG-mediated calpain2 gene silencing in the brain impairs learning and memory [0.03%]
神经元中利用RVG递送的Calpain2基因干扰影响学习记忆功能研究
Sohila Zadran,Garnik Akopian,Homera Zadran et al.
Sohila Zadran et al.
In the central nervous system, two calpain isoforms are highly expressed: calpain1 and calpain2. Here, we show for the first time that activation of the calpain isoform, calpain2, is a necessary event in hippocampal synaptic plasticity and ...
Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility [0.03%]
在偏头痛易感性中识别一种新的ANKK1及其他多巴胺能( DRD2 和DBH )基因变异体
Jayashri Ghosh,Sunil Pradhan,Balraj Mittal
Jayashri Ghosh
The dopaminergic system plays an important role in migraine and its clinical subtypes. Hypersensitization of dopamine receptor type 2 (DRD2) in migraine led to successful administration of receptor antagonists in antimigraine therapy. Ankyr...
Meta-Analysis
Neuromolecular medicine. 2013 Mar;15(1):61-73. DOI:10.1007/s12017-012-8195-9 2013
Reduction of AP180 and CALM produces defects in synaptic vesicle size and density [0.03%]
AP180和CALM的减少会影响网格蛋白包被小泡的大小及密度
Ronald S Petralia,Ya-Xian Wang,Fred E Indig et al.
Ronald S Petralia et al.
Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse. Although studies using ...
MicroRNAs: a light into the "black box" of neuropediatric diseases? [0.03%]
微RNA：能否成为神经儿科疾病研究“黑匣子”的一盏明灯？
Ahmed Omran,Dalia Elimam,Sherien Shalaby et al.
Ahmed Omran et al.
Although there have been tremendous advances in the diagnosis and treatment of pediatric brain diseases in the last few decades, the causes and pathogenesis of these diseases remain to be elucidated. Pediatric central nervous system (CNS) d...
Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents [0.03%]
接触海湾战争毒剂后出现感觉运动缺陷和类似焦虑特征的小鼠脑中磷胆碱脂质的脂质组学分析
Laila Abdullah,James E Evans,Alex Bishop et al.
Laila Abdullah et al.
The central nervous system (CNS)-based symptoms of Gulf War Illness (GWI) include motor dysfunction, anxiety, and cognitive impairment. Gulf War (GW) agents, such as pyridostigmine bromide (PB), permethrin (PER), N,N-diethyl-meta-toluamide ...
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation [0.03%]
甲基乙二醛通过促进AGEs的形成诱导Tau过度磷酸化
Xiao-Hong Li,Jia-Zhao Xie,Xia Jiang et al.
Xiao-Hong Li et al.
The hyperphosphorylated tau is a major protein component of neurofibrillary tangle, which is one of hallmarks of Alzheimer's disease (AD). While the level of methylglyoxal (MG) is significantly increased in the AD brains, the role of MG in ...
Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1 [0.03%]
由增加肌肉氯通道CLC-1开放概率的突变引起的显性遗传先天性肌强直症
David P Richman,Yawei Yu,Ting-Ting Lee et al.
David P Richman et al.
Myotonia congenita-inducing mutations in the muscle chloride channel CLC-1 normally result in reduced open probability (P (o)) of this channel. One well-accepted mechanism of the dominant inheritance of this disease involves a dominant-nega...
IL6 protects MN9D cells and midbrain dopaminergic neurons from MPP+-induced neurodegeneration [0.03%]
IL6通过保护MN9D细胞和中脑多巴胺能神经元免受MPP+诱导的神经退行性病变发挥作用
Björn Spittau,Xiaolai Zhou,Ming Ming et al.
Björn Spittau et al.
The degeneration of midbrain dopaminergic (mDA) neurons is the hallmark of Parkinson's disease (PD), and several in vivo and in vitro models have been established to resemble the processes occurring during disease progression. One of the mo...
Comparative Study
Neuromolecular medicine. 2012 Dec;14(4):317-27. DOI:10.1007/s12017-012-8189-7 2012
Functional differences of miR-125b on the invasion of primary glioblastoma CD133-negative cells and CD133-positive cells [0.03%]
miR-125b对胶质母细胞瘤CD133阴性细胞和CD133阳性细胞侵袭功能的差异作用
Lei Shi,Yi Wan,Guan Sun et al.
Lei Shi et al.
MicroRNAs (miRNAs) are small noncoding RNAs whose function as modulators of gene expression is crucial for the proper control of cell development, differentiation, and homeostasis. The total number and composition of miRNAs expressed per ce...
Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease [0.03%]
精神分裂症患者背外侧前额叶白质中 prohibitin 免疫反应性少突胶质细胞密度增加提示该蛋白在疾病中的胞外作用
Hans-Gert Bernstein,Karl-Heinz Smalla,Diana Dürrschmidt et al.
Hans-Gert Bernstein et al.
Prohibitin has previously been implicated in the synaptic pathology of schizophrenia. The recently discovered abundant expression of prohibitin in human prefrontal oligodendrocytes raises the issue, whether this protein might also be part o...