Leptin and Leptin Signaling in Multiple Sclerosis: A Narrative Review [0.03%]
在多发性硬化症中脂肪因子和脂肪因子信号的叙述综述
Juan Antonio Flores-Cordero,Amalia Aranaz-Murillo,Teresa Vilariño-García et al.
Juan Antonio Flores-Cordero et al.
Obesity, a pandemic health problem, is now considered as a chronic inflammatory state, related to many autoimmune diseases, such as multiple sclerosis. Thus, adipokines, inflammatory mediators secreted by adipose tissue, play an important r...
NOTCH3 Variant Position Affects the Phenotype at the Pluripotent Stem Cell Level in CADASIL [0.03%]
CADASIL中NOTCH3变异体位置影响多能干细胞水平的表型
Ana Bugallo-Casal,Elena Muiño,Susana B Bravo et al.
Ana Bugallo-Casal et al.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common genetic form of stroke. It is caused by a cysteine-altering variant in one of the 34 epidermal growth factor-like repeat...
Annexin A's Life in Pan-Cancer: Especially in Glioma Immune Cells [0.03%]
附睾蛋白A在泛癌中的生活：特别体现在胶质瘤免疫细胞中
Yujing Wen,Wenhao Zhou,Zhenzhen Zhao et al.
Yujing Wen et al.
The Annexin A (ANXA) family plays a critical role in cancer, with particular emphasis on their prognostic significance in pan-cancer analyses and gliomas. By integrating multi-omics data from The Cancer Genome Atlas (TCGA) and single-cell s...
ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation [0.03%]
ADAR1通过促进NUPR1的A-to-I RNA编辑来加剧由小胶质细胞介导的神经炎症导致的缺血性脑损伤
Guo-Ping Wang,Wen-Juan Li,Ye Li et al.
Guo-Ping Wang et al.
Microglial cells occupy a crucial position as potential therapeutic targets in the context of ischemic stroke (IS). Nonetheless, the intrinsic mechanisms that govern microglial activation in the aftermath of IS remain incompletely elucidate...
Therapeutic Potential of TUBB6 Inhibition for Hematoma Reduction, Microtubule Stabilization, and Neurological Recovery in an In Vivo Model of Intracerebral Hemorrhage [0.03%]
TUBB6抑制在体内脑出血模型中减少血肿、稳定微管和神经恢复的治疗潜力
Jun-Yao Huang,Qiang Ma,Ya-Jie Qi et al.
Jun-Yao Huang et al.
This in vivo study explored the impact of TUBB6 inhibition in intracerebral hemorrhage (ICH), focusing on its effects on hematoma volume, microtubule stability, inflammation, neuronal preservation, and sensorimotor recovery. Sprague-Dawley ...
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat [0.03%]
乳酸菌在改善行为缺陷、提高维生素D3和B12血清水平以及降低氧化应激和大鼠铜氨酞诱导的脱髓鞘模型中脱髓鞘的作用
Maryam Kazemimiraki,Elham Moazamian,Mohammad Javad Mokhtari et al.
Maryam Kazemimiraki et al.
Multiple sclerosis constitutes a chronic, inflammatory, and demyelinating disorder affecting the central nervous system, with an estimated global prevalence of 2.5 million individuals. Emerging research underscores the significant influence...
Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes [0.03%]
受伤的时间对两种性别的小鼠的行为和组织学结果影响较小
Charles K Davis,Soomin Jeong,Shruti Subramanian et al.
Charles K Davis et al.
Transcription of > 50% of the mammalian coding genes follows circadian rhythm in an organ-specific manner. Recent findings highlighted the influence of time of the day in the progression of various neurological diseases and therapies. In th...
Seipin Deficiency Impairs Motor Coordination in Mice by Compromising Spinal Cord Myelination [0.03%]
塞宾缺陷通过损害脊髓髓鞘化而损害小鼠运动协调能力
Hong Chen,Wenru Wang,Wenli Cui et al.
Hong Chen et al.
The integrity of the myelin sheath of the spinal cord (SC) is essential for motor coordination. Seipin is an endoplasmic reticulum transmembrane protein highly expressed in adipose tissue and motor neurons in the SC. It was reported Seipin ...
Bacopa monnieri Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus [0.03%]
Bacopa monnieri提取物通过调节海马区缺氧诱导因子-1α信号通路及抗氧化防御系统来缓解缺氧诱发的焦虑反应
Upendra Kumar Meena,Akhilendra Kumar Maurya
Upendra Kumar Meena
Hypoxia is a significant stressor, and stabilized hypoxia-inducible factor-1α (HIF-1α) regulates the expression of numerous genes, leading to various biochemical, molecular, physiological and genomic changes. The body's oxygen-sensing sys...
Mohamed J Saadh,Omer Qutaiba B Allela,Radhwan Abdul Kareem et al.
Mohamed J Saadh et al.
The primary source of short-chain fatty acids (SCFAs), now recognized as critical mediators of host health, particularly in the context of neurobiology and cancer development, is the gut microbiota's fermentation of dietary fibers. Recent r...