Gastrodin Protects Neuronal Cells Against Oxidative Stress Through miRNA-125b-5p/Mamdc2 Axis [0.03%]
gastrodin通过miRNA-125b-5p/MAMDC2轴保护神经元细胞免受氧化应激损伤
Lei Hu,Chao Lin,Renfu Li et al.
Lei Hu et al.
Deregulated reactive oxygen species (ROS) levels trigger oxidative stress (OS) injury that is closely associated with the pathophysiology of various neurological disorders. Therefore, therapeutic efforts at oxidative events in the pathway o...
Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase [0.03%]
神经D2在缺血病理生理中的作用：与AKT生存激酶相关的神经保护机制的启示
Busenur Bolat,Cigdem Bayraktaroglu,Zehra Degirmenci et al.
Busenur Bolat et al.
NeuroD2 (ND2), a neuron-specific transcription factor, is essential in neural differentiation and neuroplasticity, yet its regulation under neuronal injury is barely uncovered. Effective treatment strategies for ischemic conditions require ...
CaMKIIα-NpHR-Mediated Optogenetic Inhibition of DRG Glutamatergic Neurons by Flexible Optic Fiber Alleviates Chronic Neuropathic Pain [0.03%]
CA MK IIα-NpHR介导的灵活光纤调控下DRG谷氨酸能神经元的光遗传学抑制缓解慢性神经病理性疼痛
Jaisan Islam,Md Taufiqur Rahman,Muhammad Ali et al.
Jaisan Islam et al.
Glutamatergic neurons of the dorsal root ganglion (DRGg) exert a significant effect on peripheral nociceptive signal transmission. However, assessing the explicit modulatory effect of DRGg during chronic neuropathic pain (CNP) with neuromod...
Neuropeptide Signaling in Glioblastoma: A Comprehensive Review of the Current State and Future Direction [0.03%]
神经肽在胶质母细胞瘤中的信号转导：现状及未来方向的全面综述
Shahid Afridi,Mohd Muzzammil,Intezar Ali et al.
Shahid Afridi et al.
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by complex pathophysiology and significant clinical challenges. Emerging research emphasizes the crucial role of neuropeptides in GBM and its influence on tumor ...
Exploring NLRP3 Inhibition as a Key Modulator in Neonatal Hypoxic-Ischemic Brain Injury [0.03%]
探索NLRP3抑制在新生儿缺氧缺血性脑损伤中的关键作用
Khiany Mathias,Richard Simon Machado,Taise Cardoso et al.
Khiany Mathias et al.
Neonatal hypoxic-ischemic (HI) injury is a critical condition associated with significant acute brain damage and long-term neurological impairments. Growing evidence highlights the role of the NOD-like receptor family, pyrin domain containi...
5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression [0.03%]
基于基因表达的网络生物学和机器学习在运动神经元和肌萎缩侧索硬化症肌肉组织中鉴定出五种再定位药物候选物
Kubra Temiz,Aytac Gul,Esra Gov
Kubra Temiz
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to motor neuron degeneration, muscle weakness, and respiratory failure. Despite ongoing research, effective treatments for ALS are limited. This stud...
Meta-Analysis
Neuromolecular medicine. 2025 Apr 3;27(1):24. DOI:10.1007/s12017-025-08847-z 2025
Folic Acid Promotes Peripheral Nerve Injury Repair via Regulating DNM3-AKT Pathway Through Mediating Methionine Cycle Metabolism [0.03%]
叶酸通过介导蛋氨酸循环代谢调节DNM3-AKT通路促进周围神经损伤修复
Weibo Kang,Yanli Zhang,Wei Cui et al.
Weibo Kang et al.
Emerging evidence suggests that folic acid (FA) supports nerve repair, but its beneficial effects in peripheral nerve injury (PNI) remains unclear. This study aims to investigate protective effects of FA against PNI and the underlying molec...
The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia-Reperfusion Injury [0.03%]
G蛋白偶联受体激酶4在脑缺血再灌注损伤调节线粒体自噬和氧化应激中的作用
Jian Wang,Diheng Gu,Ke Jin et al.
Jian Wang et al.
Cerebral ischemia-reperfusion injury (CIRI) causes significant neuronal damage through oxidative stress, inflammation, and mitochondrial dysfunction. The G-protein-coupled receptor kinase 4 (GRK4) has been implicated in regulating stress re...
SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer's Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia [0.03%]
SP3介导的GRIK1转录激活通过诱导小胶质细胞中炎症小体的活化参与阿尔茨海默病引起的认知功能下降
Xiaolin Pang,Zhun Wang,Mengxue Zhang et al.
Xiaolin Pang et al.
GRIK1 has been identified to suppress the activation of NLRP3 inflammasome. The present study investigated the damaging effect of GRIK1 on Alzheimer's disease (AD), the most common neurodegenerative disease, by focusing on inflammasome. APP...
The Peripheral Amyloid-β Nexus: Connecting Alzheimer's Disease with Atherosclerosis through Shared Pathophysiological Mechanisms [0.03%]
周边淀粉样蛋白-β枢纽：通过共同的病理生理机制关联阿尔茨海默病与动脉粥样硬化
Manal M Khowdiary,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Manal M Khowdiary et al.
Alzheimer's disease (AD) and atherosclerosis (AS) are two chronic diseases with seemingly distinct pathologies. However, emerging research points to a bidirectional relationship driven by common mechanisms, such as inflammation, oxidative s...