Scopoletin Attenuates Reserpine-Induced Pain-Depression Dyad in Mice via Modulation of Inflammation, Oxidative Stress, and Monoaminergic Pathways [0.03%]
scopoletin通过调节炎症、氧化应激和单胺类通路缓解番木鳖碱诱导的小鼠疼痛抑郁共病作用
Esam Qnais,Omar Gammoh,Yousra Bsieso et al.
Esam Qnais et al.
Pain and depression frequently are comorbid and have common mechanisms such as monoamine depletion, inflammation, and oxidative stress. Hence, this study aimed to investigate the effects of bioactive coumarin on reserpine induced pain-depre...
Knockdown of RUNX2 Attenuated A1 Astrocyte Overactivation, Brain Injury, and Cerebral Edema During Ischemic Stroke [0.03%]
RUNX2基因敲低通过抑制A1星形胶质细胞活化减轻脑缺血损伤和脑水肿
Zhibing Ai,Wei Huang,Wei Hu et al.
Zhibing Ai et al.
Although researchers began to unravel the potential significance of Runt-related transcription factor 2 (RUNX2) in some of neurological diseases, the role of RUNX2 in ischemic stroke remained unclear. Blood samples and clinical information ...
Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway [0.03%]
小檗胺通过抑制NF-κB信号通路调控脊髓损伤后炎症微环境
Zihao Fan,Lei Ye,Shijie Wang et al.
Zihao Fan et al.
Spinal Cord Injury (SCI) is a severe disorder of the central nervous system, typically caused by trauma or disease, which significantly impacts the quality of life of affected individuals. Secondary inflammation following spinal cord injury...
Altered Microglial Plasticity in the Periaqueductal Grey of Pre-Symptomatic Mecp2-Heterozygous Mice Following Early-Life Stress [0.03%]
早年应激后无症状期Mecp2杂合小鼠导水管周围灰质区小胶质细胞可塑性改变
Maria Abellán-Álvaro,Lidia Primo-Hernando,Elena Martínez-Rodríguez et al.
Maria Abellán-Álvaro et al.
Rett syndrome (RTT), a severe neurodevelopmental disorder primarily affecting girls, is commonly caused by MECP2 loss-of-function mutations. Key symptoms include motor impairments, typical hand stereotypies and intellectual disability. More...
Memory-Enhancing Effects of Dauricine in Swiss Mice: Possible Molecular Interventions Through In Vivo and In Silico Studies [0.03%]
大乌药碱对瑞士小鼠记忆力提升作用：通过体内和体外实验探讨其可能的分子干预机制
Md Showkot Akbor,Md Sakib Al Hasan,Mst Farjanamul Haque et al.
Md Showkot Akbor et al.
The bisbenzylisoquinoline alkaloid dauricine (DAU) is known for its neuroprotective effects in animals. This study investigates the memory-enhancing effects of DAU in Swiss albino mice using both in vivo and in silico approaches, focusing o...
Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases [0.03%]
来自SPAM转基因小鼠的tau表现出强大的菌株特异性-prion-like种子特性，这是人类神经退行性疾病的特征
Ethan D Smith,Giavanna Paterno,Brach M Bell et al.
Ethan D Smith et al.
Tauopathies, including Alzheimer's disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by the aberrant aggregation of tau protein into neurofibrillary tangles. Despite extensive studies...
Protective Effect of the LRRK2 Kinase Inhibition in Human Fibroblasts Bearing the Genetic Variant GBA1 K198E: Implications for Parkinson's Disease [0.03%]
携带GBA1 K198E基因变异的人成纤维细胞中LRRK2激酶抑制的保护作用：对帕金森病的意义
Laura Patricia Perez-Abshana,Miguel Mendivil-Perez,Carlos Velez-Pardo et al.
Laura Patricia Perez-Abshana et al.
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder for which there are currently no curative therapies. Therefore, the need for innovative treatments for this illness is critical. The glucosylceramidase beta 1 ...
Deregulation of Neuroinflammatory and Neurotrophic Factors as Biological Events Triggered by D-Galactose Chronic Administration in Wistar Rats [0.03%]
Wistar大鼠慢性D-半乳糖给药诱发的生物学事件中神经炎症和神经营养因子失调节的作用机制研究
Eduarda Behenck Medeiros,Sabrina da Silva,Francielle Mina et al.
Eduarda Behenck Medeiros et al.
The chronic administration of D-galactose (D-gal) is widely used to model brain senescence in rodents. However, the effects of prolonged oral exposure of D-gal on the neuroinflammatory cytokines in rats remain poorly characterized. Therefor...
Abhishek Kumar Mishra,Shreya Dixit,Akanksha Singh et al.
Abhishek Kumar Mishra et al.
In the human brain, the nigrostriatal pathway regulates motor functions, and its selective deterioration leads to the onset of Parkinson's disease (PD), a neurodegenerative disorder characterized by motor dysfunction and significant disabil...
Exploring Proteomic Alterations in Intellectual Disability: Insights from Hyperlipidemia and Hyperphosphatasia Subgroups [0.03%]
探索智力障碍中的蛋白质组学改变：高脂血症和高磷酶症亚群的启示
Soma Vankwani,Munazza Raza Mirza,Muhammad Tahir et al.
Soma Vankwani et al.
A significant increase of neurodevelopment disorders (NDDs) among children presents growing healthcare challenge worldwide. Owing to heterogenic, multifactorial nature of NDDs, understanding pathophysiology of disease, finding effective met...