A Slower-Progressing TDP-43 rNLS8 Mouse Model for ALS: Implications for Preclinical and Mechanistic Studies [0.03%]
用于ALS的进展较慢的TDP-43 rNLS8小鼠模型及其在临床前和机制研究中的意义
Cyril Jones Jagaraj,Prachi Mehta,Julie Hunter et al.
Cyril Jones Jagaraj et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by motor neuron degeneration, muscle weakness, paralysis, and eventual death, with TAR DNA-binding protein 43 (TDP-43) pathology observed in almost all c...
Antonello Pinna,Julia Kistowska,Artur Pałasz
Antonello Pinna
Depression is a leading global cause of disability. Emerging evidence highlights glutamatergic dysfunction, particularly impaired NMDA receptor signaling, as a key contributor to its neurobiology. Hydrogen sulfide (H₂S), once regarded sole...
Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity [0.03%]
通过抑制PKM2活性来调节脊髓损伤后继发性炎症的番石榴素的作用机制研究
Bin Dai,Zihao Fan,Rui Chen et al.
Bin Dai et al.
Excessive pro-inflammatory polarization of microglia is a critical driver of secondary inflammation following spinal cord injury (SCI). Jaceosidin, a natural flavonoid with established anti-inflammatory properties, has not been extensively ...
Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway [0.03%]
磷Creatine通过NF-κB/PGC-1α通路调节线粒体功能和细胞凋亡缓解多柔比星致大鼠神经毒性
Eskandar Qaed,Waleed Aldahmash,Mueataz A Mahyoub et al.
Eskandar Qaed et al.
Doxorubicin (DOX) is an effective chemotherapeutic agent, but its clinical utility is limited by its neurotoxic side effects. This study investigates the neuroprotective effects of phosphocreatine (PCr) against DOX-induced neurotoxicity in ...
Platycodin D Attenuates Behavioral Deficits, Amyloid-β Accumulation and Mitochondrial Impairment in AD Models by Inhibiting the cGAS-STING Pathway [0.03%]
Platycodin D通过抑制cGAS-STING途径缓解阿尔茨海默病模型的行为缺陷、淀粉样蛋白-β沉积和线粒体损伤
Chaoyuan Song,Guoliang Yin,Linya Wang et al.
Chaoyuan Song et al.
The characteristics of Alzheimer's disease (AD) include behavioral deficits, amyloid-β (Aβ) accumulation, and mitochondrial impairment. Activating of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway signific...
Exploring Core Genes Involved in Ischemic Stroke and the Therapeutic Potential of Hyperbaric Oxygen: Insights from Transcriptomic Analysis [0.03%]
基于转录组学分析的急性缺血性卒中核心基因鉴定及高压氧治疗作用研究
Yingcun Bao,Xudong Guo,Jinhai Wang et al.
Yingcun Bao et al.
Ischemic stroke (IS) is a complex neurological disorder caused by reduced cerebral blood flow, typically resulting in tissue damage due to hypoxia and nutrient deficiency. Hyperbaric oxygen therapy (HBOT) has shown great potential as an adj...
Inflammatory Markers and their Relationship with Cognitive Function in Alzheimer's Disease and Mild Cognitive Impairment. Systematic Review and Meta-Analysis [0.03%]
炎症标志物与阿尔茨海默病和轻度认知障碍患者认知功能的关系：系统评价和meta分析
Maria Fernanda Serna,Mildrey Mosquera,Herney Andrés García-Perdomo
Maria Fernanda Serna
This study estimates the association between blood levels of inflammatory markers and cognitive function in adults with Alzheimer's disease or mild cognitive impairment. A systematic review and meta-analysis were conducted to synthesize dat...
Ca2+-Affinitive and Non-Ca2+-Affinitive Synaptotagmins in Human Pan-cancer [0.03%]
人类泛癌中钙依赖性和非钙依赖性突触结合蛋白-1家族成员的表达及预后价值分析
Xuanang Wu,Bo Gao,Kun Xiao et al.
Xuanang Wu et al.
Synaptotagmins (Syts) are a family of crucial Ca2+ sensors for cellular secretions, while half of the Syt isoforms are evolutionarily non-Ca2+-affinitive, which are less studied but associated with several neuro-system diseases. Some Syt is...
Equol as a Multitarget Agent Against Neurodegeneration: Mechanistic Insights into Its Molecular Modulation [0.03%]
equol对抗神经退行性病变的多靶标作用机制及其分子调节作用的见解
Nushrat Jahan,Lovedeep Singh,Jyoti Sharma
Nushrat Jahan
Neurodegenerative diseases consist of a group of progressive disorders characterized by the gradual decline in the structure or function of neurons, which ultimately results in neuronal death. The occurrence and societal effects of these di...
Dysbiosis and Neurodegeneration in ALS: Unraveling the Gut-Brain Axis [0.03%]
ALS中神经退行性病变与菌群失调：解开肠-脑轴之谜
Vivek Kumar Sharma
Vivek Kumar Sharma
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disorder marked by the progressive degeneration of motor neurons in the brain and spinal cord. Despite decades of research, ALS remains incurabl...