Spautin-1 Protects Against Mild TBI-Induced Anxiety-Like Behavior in Mice via Immunologically Silent Apoptosis [0.03%]
新型化合物Spautin-1可通过非免疫型凋亡途径保护小鼠免于轻度创伤性脑损伤引起的类似焦虑行为
Hui-Tao Miao,Rong-Xin Song,Yue Xin et al.
Hui-Tao Miao et al.
Anxiety is reportedly one of the most common mental changes after traumatic brain injury (TBI). Perineuronal nets (PNNs) produced by astrocytes in the lateral hypothalamus (LHA) that surround gamma-aminobutyric acid-ergic (GABAergic) neuron...
The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease [0.03%]
泛素-蛋白酶体系统在帕金森病治疗中的作用
Kumar Suresh,Michael Mattern,Matthew S Goldberg et al.
Kumar Suresh et al.
Parkinson's disease (PD) is the most common neurodegenerative movement disorder. There are no available therapeutics that slow or halt the progressive loss of dopamine-producing neurons, which underlies the primary clinical symptoms. Curren...
Transient Receptor Potential Mucolipin-1 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury by Inducing Neuroinflammation and Neuronal Cell Death [0.03%]
瞬时受体电位黏蛋白1通过诱导神经炎症和神经元细胞死亡参与脑出血后继发性脑损伤
Jinzhao Shi,Xiang Li,Jiasheng Ding et al.
Jinzhao Shi et al.
Transient receptor potential mucolipin-1 (TRPML1) is the most abundantly and widely expressed channel protein in the TRP family. While numerous studies have been conducted involving many aspects of TRPML1, such as its role in cell biology, ...
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation [0.03%]
α-突触核蛋白通过与OX1R的相互作用诱发RBD的发生并调节其降解过程
Jing Kai Fan,Meng Chen Wang,Hui Min Yang et al.
Jing Kai Fan et al.
Rapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of Parkinson's disease (PD), but the pathogenetic mechanism involved in RBD remains largely unexplored. α-Synuclein has been verified to form Lewy bodies in th...
CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis [0.03%]
CD33/TREM2信号通过调节小胶质细胞的吞噬作用介导睡眠剥夺引起的记忆损伤
Shuwen Tan,Hui Gao,Jianyu Sun et al.
Shuwen Tan et al.
Sleep deprivation causes significant memory impairment in healthy adults. Extensive research has focused on identifying the biological mechanisms underlying memory impairment. Microglia-mediated synaptic elimination plays an indispensable r...
Involvement of Microbiome Gut-Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury [0.03%]
鼠类反复轻度创伤性脑损伤模型中微生态肠-脑轴参与黄芩素的神经保护效应
Ramya Balasubramanian,Mohd Rabi Bazaz,Tulasi Pasam et al.
Ramya Balasubramanian et al.
Repeated mild traumatic brain injury (rmTBI) poses adversity in the form of neurological deficits. The ignition of long-term neurological aberrations post-TBI is appended with the microbiota gut-brain axis perturbation. Herein, we examined ...
Tau and GSK-3β are Critical Contributors to α-Synuclein-Mediated Post-Stroke Brain Damage [0.03%]
Tau和GSK-3β是α-突触核蛋白介导的脑卒中后脑损伤的关键贡献因素
Suresh L Mehta,TaeHee Kim,Bharath Chelluboina et al.
Suresh L Mehta et al.
Post-stroke secondary brain damage is significantly influenced by the induction and accumulation of α-Synuclein (α-Syn). α-Syn-positive inclusions are often present in tauopathies and elevated tau levels and phosphorylation promotes neur...
The Mood Stabilizer Lithium Slows Down Synaptic Vesicle Cycling at Glutamatergic Synapses [0.03%]
mood stabilizer锂在谷氨酸递质突触中减缓囊泡循环速度
Willcyn Tang,Bradley Cory,Kah-Leong Lim et al.
Willcyn Tang et al.
Lithium is a mood stabilizer broadly used to prevent and treat symptoms of mania and depression in people with bipolar disorder (BD). Little is known, however, about its mode of action. Here, we analyzed the impact of lithium on synaptic ve...
SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation [0.03%]
SS-31通过抑制Drp1-NLRP3炎性小体活化改善脓毒症相关脑病的认知功能
Lanlan Zhong,Xingshu Ren,Yuhang Ai et al.
Lanlan Zhong et al.
Neuroinflammation and microglial activation are involved in the pathogenesis of sepsis-associated encephalopathy (SAE). Mitochondrial dynamics emerged as a new player in the regulation of immunological processes. In this study, we aimed at ...
Neuroprotective Effects of Carbonic Anhydrase Inhibition and Cyclic Adenosine Monophosphate Activation in Mouse Model of Transient Global Cerebral Ischemia and Reperfusion [0.03%]
碳酸酐酶抑制和环鸟苷酸激活的神经保护作用：短暂全脑缺血及再灌注小鼠模型研究
Manish Kumar,Komalpreet Kaur,Thakur Gurjeet Singh
Manish Kumar
Cerebral ischemia is the primary basis of stroke, both sharing common pathogenic origins leading to irreversible brain damage if blood supply is not restored promptly. Existing evidence indicates that carbonic anhydrase (CA) inhibitors (CAI...