Shuqi Hu,Bingjie Yang,Song Shu et al.
Shuqi Hu et al.
Pericytes surrounding endothelial cells in the capillaries are emerging as an attractive cell resource, which can show a large variety of functions in ischemic stroke, including preservation of the blood-brain barrier, regulation of immune ...
David E Wong Zhang,Vivian Tran,Antony Vinh et al.
David E Wong Zhang et al.
Obesity is a major global health concern, with prevalence rates rapidly rising due to increased availability of highly processed foods rich in fats and/or sugars and technological advances promoting more sedentary behaviour. There is increa...
Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease? [0.03%]
炎症在阿尔茨海默病发病机制中起主要作用吗？
Benita Wiatrak,Paulina Jawień,Adam Szeląg et al.
Benita Wiatrak et al.
Alzheimer's disease (AD) is a neurodegenerative disease leading to dementia for which no effective medicine exists. Currently, the goal of therapy is only to slow down the inevitable progression of the disease and reduce some symptoms. AD c...
Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers [0.03%]
无治疗的复发缓解型多发性硬化症脑脊液和血液外泌体微RNA多重分析并提出非侵入式诊断生物标志物
Mina Mohammadinasr,Soheila Montazersaheb,Ommoleila Molavi et al.
Mina Mohammadinasr et al.
Exosomal microRNAs (miRNAs) are emerging diagnostic biomarkers for neurodegenerative diseases. In this study, we aimed to detect relapsing-remitting multiple sclerosis (RRMS)-specific miRNAs in cerebrospinal fluid (CSF) and serum exosomes w...
Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose [0.03%]
度米芬通过AMPK/mTOR信号通路调节自噬以改善高糖诱导的神经细胞损伤
Pinzhong Chen,Xiaohui Chen,Honghong Zhang et al.
Pinzhong Chen et al.
Neurodegenerative diseases and postoperative cognitive dysfunction involve the accumulation of β-amyloid peptide (Aβ). High glucose can inhibit autophagy, which facilitates intracellular Aβ clearance. The α2-adrenoreceptor agonist dexme...
Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis [0.03%]
精神分裂症患者脑样本中S100基因家族的上调：荟萃分析
Anat Shamir,Assif Yitzhaky,Aviv Segev et al.
Anat Shamir et al.
The S100 proteins family is known to affect neuroinflammation and astrocyte activation, which have been suggested to be contributors to the pathogenesis of schizophrenia. We conducted a systematic meta-analysis of S100 genes differential ex...
Transcriptome Analysis of the Mouse Medial Prefrontal Cortex in a Chronic Constriction Injury Model [0.03%]
慢性压迫损伤模型小鼠前额叶皮层转录组分析
Qi-Min Zheng,Zi-Rui Zhou,Xin-Yu Hou et al.
Qi-Min Zheng et al.
The medial prefrontal cortex (mPFC) is critical for both the sensory and emotional/cognitive components of pain. However, the underlying mechanism remains largely unknown. Here, we examined changes in the transcriptomic profiles in the mPFC...
Whether the Subacute MPTP-Treated Mouse is as Suitable as a Classic Model of Parkinsonism [0.03%]
亚急性MPTP诱导的小鼠模型是否能作为经典帕金森病动物模型使用
Yue Qi,Ziwei Zhang,Yanning Li et al.
Yue Qi et al.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model is one of the most common animal models for Parkinson's disease (PD). It is classified into three types: acute, subacute, and chronic intoxication models. The subacute model has...
IL-17A Facilitates Entry of Autoreactive T-Cells and Granulocytes into the CNS During EAE [0.03%]
IL-17A促进自身反应性T细胞和中性粒细胞在EAE中进入中枢神经系统
Julian Zimmermann,Louisa Nitsch,Marius Krauthausen et al.
Julian Zimmermann et al.
Interleukin-17A plays a crucial role in multiple sclerosis and other autoimmune diseases. Although the link between IL-17 and disease activity has been clearly demonstrated, the precise function of this cytokine remains elusive. Here, we in...
The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis [0.03%]
PGK1通过调节糖酵解促进缺血再灌注损伤诱导的小胶质M1极化和炎症的作用
Wei Cao,Zhengzhe Feng,Deyuan Zhu et al.
Wei Cao et al.
Stroke is a leading cause of death, with a continuously increasing incidence. As a metabolic process that catabolizes glucose pyruvate and provides adenosine triphosphate (ATP), glycolysis plays a crucial role in different diseases. Phospho...