The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation [0.03%]
血清素代谢基因CYP46A1多态性与自杀风险的关联研究
María Fernanda Serna-Rodríguez,Oscar Cienfuegos-Jiménez,Ricardo Martín Cerda-Flores et al.
María Fernanda Serna-Rodríguez et al.
Suicide is a global public health issue, with a particularly high incidence in individuals suffering from Major Depressive Disorder (MDD). The role of cholesterol in suicide risk remains controversial, prompting investigations into genetic ...
Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis [0.03%]
抑制p70核糖体S6 kinase（S6K1）可减少自闭症-结节硬化症大鼠模型的皮层血流
Oak Z Chi,Xia Liu,Harvey Fortus et al.
Oak Z Chi et al.
The manifestations of tuberous sclerosis complex (TSC) in humans include epilepsy, autism spectrum disorders (ASD) and intellectual disability. Previous studies suggested the linkage of TSC to altered cerebral blood flow and metabolic dysfu...
Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin-Proteasome System Activation [0.03%]
tetramethyl吡嗪硝酮通过Nrf2介导的泛素-蛋白酶体系统激活促进α-突触核蛋白清除
Baojian Guo,Chengyou Zheng,Jie Cao et al.
Baojian Guo et al.
Aggregation of α-synuclein (α-syn) and α-syn cytotoxicity are hallmarks of sporadic and familial Parkinson's disease (PD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent enhancement of the expression of the 20S proteasome c...
Ankit Patel,Ashutosh Dharap
Ankit Patel
Noncoding DNA undergoes widespread context-dependent transcription to produce noncoding RNAs. In recent decades, tremendous advances in genomics and transcriptomics have revealed important regulatory roles for noncoding DNA elements and the...
Acetylation of c-Myc at Lysine 148 Protects Neurons After Ischemia [0.03%]
缺血后保护神经元的c-Myc乙酰化作用及机制研究(K148)
V V Guzenko,S S Bachurin,V A Dzreyan et al.
V V Guzenko et al.
This study focuses on understanding the role of c-Myc, a cancer-associated transcription factor, in the penumbra following ischemic stroke. While its involvement in cell death and survival is recognized, its post-translational modifications...
Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer's Disease [0.03%]
散发性早发阿尔茨海默病家系中疑似新型APP Met671Leu突变的致病作用分析
Limin Ma,Fengyu Wang,Shuai Chen et al.
Limin Ma et al.
Familial Alzheimer's disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding presenilin 1), and PSEN2 (encoding presenilin 2) are the most common genes cause dominant ...
MiR206 and 423-3p Are Differently Modulated in Fast and Slow-Progressing Amyotrophic Lateral Sclerosis Patients [0.03%]
miR206 和423-3p 在进展快慢不同的肌萎缩侧索硬化症病人中表现出不同的调控模式
Antonio Musarò,Gabriella Dobrowolny,Chiara Cambieri et al.
Antonio Musarò et al.
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease with a wide disease progression. Despite several efforts to develop efficient biomarkers, many concerns about the available ones still need to be addressed. MicroRNA (miR) ...
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia-Reperfusion Model of Rats [0.03%]
2周佛手柑内酯补充对缺血再灌注大鼠模型的神经元生成和BDNF水平的影响
Esen Yilmaz,Gozde Acar,Ummugulsum Onal et al.
Esen Yilmaz et al.
Background: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors living with serious neurological sequelae; thus, it has recently attracted a lot of attention in the ...
Uncovering Sex-Specific Epigenetic Regulatory Mechanism Involving H3k9me2 in Neural Inflammation, Damage, and Recovery in the Internal Carotid Artery Occlusion Mouse Model [0.03%]
在内颈动脉闭塞小鼠模型中揭示涉及H3k9me2的性特异性表观遗传调控机制在神经炎症、损伤和恢复中的作用
Mydhili Radhakrishnan,Vincy Vijay,B Supraja Acharya et al.
Mydhili Radhakrishnan et al.
Cerebral ischemic stroke is one of the foremost global causes of death and disability. Due to inadequate knowledge in its sequential disease mechanisms, therapeutic efforts to mitigate acute ischemia-induced brain injury are limited. Recent...
Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging [0.03%]
慢性高血压对正常血压和自发性高血压大鼠衰老过程中大脑皮层线粒体能量代谢的影响
Roberto Federico Villa,Federica Ferrari,Antonella Gorini
Roberto Federico Villa
In this study the subcellular modifications undergone by cerebral cortex mitochondrial metabolism in chronic hypertension during aging were evaluated. The catalytic properties of regulatory energy-linked enzymes of Tricarboxylic Acid Cycle ...