Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice [0.03%]
体育锻炼抑制老年小鼠的认知障碍和记忆丧失，并增强年轻和年老小鼠海马体的突触前和突触后蛋白
Ricardo Augusto Leoni De Sousa,Caique Olegário Diniz-Magalhaes,Poliany Pereira Cruz et al.
Ricardo Augusto Leoni De Sousa et al.
The aim of this study was to evaluate the effects of swimming in the brain and behavior of young and aged mice. Forty-eight male C57BL/6 J mice were randomly distributed into 4 groups (n = 12 per group, 3 and 18 months old). The subdivision...
The CD44s Isoform is a Potential Biomarker for Predicting Craniopharyngioma Recurrence in Children [0.03%]
CD44s异构体可作为预测儿童颅咽管瘤复发的生物标志物
K Bajdak-Rusinek,N Diak,E Gutmajster et al.
K Bajdak-Rusinek et al.
Adamantinomatous craniopharyngioma (ACP) is an intracranial tumor considered partly malignant due to its ability to infiltrate surrounding structures and tendency to relapse despite radical resection. CD44 is a known stem cell marker in ACP...
Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus [0.03%]
虾青素通过保护海马神经元免于凋亡来改善血管性痴呆大鼠的学习记忆障碍
Na Wei,Luo-Man Zhang,Jing-Jing Xu et al.
Na Wei et al.
Vascular dementia (VaD) is a cognitive disorder characterized by a decline in cognitive function resulting from cerebrovascular disease. The hippocampus is particularly susceptible to ischemic insults, leading to memory deficits in VaD. Ast...
Shahram Savad,Mohammad-Hossein Modarressi,Sarang Younesi et al.
Shahram Savad et al.
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in the NF1 gene. This disorder shows nearly complete penetrance and high phenotypic variability. We used the whole-exome sequencing technique to identify mutations in ...
Association of NID2 SNPs with Glioma Risk and Prognosis in the Chinese Population [0.03%]
NID2基因多态性与胶质瘤易感和预后的关系研究
Jie Hao,Congmei Huang,Weiwei Zhao et al.
Jie Hao et al.
Glioma is the most common primary intracranial tumor with high mortality and poor prognosis. The purpose of this study was to investigate how single-nucleotide polymorphisms (SNPs) of the NID2 gene affect glioma risk and prognosis. Four can...
Hydrogen Sulfide can Scavenge Free Radicals to Improve Spinal Cord Injury by Inhibiting the p38MAPK/mTOR/NF-κB Signaling Pathway [0.03%]
氢硫化物可通过抑制p38MAPK/mTOR/NF-κB信号通路清除自由基改善脊髓损伤
Kexin Lin,Yong Zhang,Yanyang Shen et al.
Kexin Lin et al.
Spinal cord injury (SCI) causes irreversible cell loss and neurological dysfunctions. Presently, there is no an effective clinical treatment for SCI. It can be the only intervention measure by relieving the symptoms of patients such as pain...
Endothelial Progenitor Cells: A Review of Molecular Mechanisms in the Pathogenesis and Endovascular Treatment of Intracranial Aneurysms [0.03%]
内皮祖细胞：颅内动脉瘤发病机制和血管内治疗的分子机制综述
Felipe Ramirez-Velandia,Emmanuel Mensah,Mira Salih et al.
Felipe Ramirez-Velandia et al.
This comprehensive review explores the multifaceted role of endothelial progenitor cells (EPCs) in vascular diseases, focusing on their involvement in the pathogenesis and their contributions to enhancing the efficacy of endovascular treatm...
FMOD Alleviates Depression-Like Behaviors by Targeting the PI3K/AKT/mTOR Signaling After Traumatic Brain Injury [0.03%]
靶向创伤性脑损伤后PI3K/AKT/mTOR信号通路 FMOD缓解类似抑郁的行为
Xuekang Huang,Ziyu Zhu,Mengran Du et al.
Xuekang Huang et al.
Depression frequently occurs following traumatic brain injury (TBI). However, the role of Fibromodulin (FMOD) in TBI-related depression is not yet clear. Previous studies have suggested FMOD as a potential key factor in TBI, yet its associa...
Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells [0.03%]
蛋白二硫异构酶内质网蛋白57（ERp57）能够保护神经元细胞免受肌萎缩侧索硬化症相关突变型TDP-43的侵害
Sonam Parakh,Emma R Perri,Marta Vidal et al.
Sonam Parakh et al.
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disease affecting motor neurons. Pathological forms of Tar-DNA binding protein-43 (TDP-43), involving its mislocalisation to the cytoplasm and the formation of misfolded incl...
Danyang Meng,Di Wu,Xiaojing Li et al.
Danyang Meng et al.
Stroke is a significant public health issue, and research has consistently focused on studying the mechanisms of injury and identifying new targets. As a CDK5 activator, p39 plays a crucial role in various diseases. In this article, we will...